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Metastatic movements in 3-D
October 06, 2008Caswell et al.report in the Journal of Cell Biology how the altered behavior of integrins can prompt metastatic movement in tumor cells.
On 2D surfaces, cells may migrate randomly, or be strongly unidirectional. Integrins, which link the cell to the extracellular matrix, are known to influence the mode of migration, but exactly how has been unclear. Recent work has suggested that an integrin called a5b1 drives random movement, while an integrin called avb3 has been associated with unidirectional migration-the balance of activity between the two determining the type of movement. To further explore the contribution of a5b1 to random migration, the authors thus blocked avb3.
The treated cells changed their mode of migration from unidirectional to random, and their ability to invade 3D gels increased. The changed behavior correlated with an increase in trafficking of a5b1 from intracellular compartments to anterior membrane protrusions. But this increase in trafficking did not significantly alter a5b1's contribution to cell adhesion-the ease with which cells were dislodged from a spinning disk increased as the amount of avb3 was reduced, but was not correlated with any change in a5b1. This suggested that the cells' increased invasive ability was due to alteration in some other property. That property turned out to be activation of a proinvasive pathway headed by a kinase called Akt.
In avb3-blocked cells, a5b1 became associated with epidermal growth factor receptor 1 (EGFR1), which increased EGFR1's abundance at the membrane protrusions, as well as its autophosphorylation. Because EGFR1 is an activator of the Akt pathway, hey presto, the cells took on some new moves.
Rockefeller University Press
In avb3-blocked cells, a5b1 became associated with epidermal growth factor receptor 1 (EGFR1), which increased EGFR1's abundance at the membrane protrusions, as well as its autophosphorylation. Because EGFR1 is an activator of the Akt pathway, hey presto, the cells took on some new moves.
Rockefeller University Press
Integrins Current Events and Integrins News RSSStem cell therapy may offer hope for acute lung injury
Researchers at the University of Illinois at Chicago College of Medicine have shown that adult stem cells from bone marrow can prevent acute lung injury in a mouse model of the disease.
Alternatively spliced tissue factor identified as promising new biomarker for aggressive cancers
A recently discovered form of the protein that triggers blood clotting may play a key role in the molecular mechanisms leading to the growth of certain metastatic cancers, according to new research reported by an international team of scientists.
Research yields potential target for cancer, wound healing and fibrosis
Research conducted by Allison Berrier, PhD, Assistant Professor of Oral and Craniofacial Biology at the LSU Health Sciences Center New Orleans School of Dentistry, and colleagues, provides insights that may help scientists design novel approaches to control wound healing and fight diseases such as cancer and fibrosis.
Protein helps immune cells to divide and conquer
Researchers at the University of California, San Diego School of Medicine have identified a key protein that is required for immune cells called B lymphocytes to divide and replicate themselves. The rapid generation of large numbers of these immune cells is critical to the body's antibody defense mechanism.
Researchers block immune cell rush behind deadly sepsis
Researchers have found a way to block the ability of white blood cells to sprint toward the sites of infection when such speed worsens the damage done by sepsis, the often fatal, whole-body bacterial infection, according to a study published today in the journal Blood.
Researchers coat titanium with polymer to improve integration of joint replacements
Research at the Georgia Institute of Technology shows that coating a titanium implant with a new biologically inspired material enhances tissue healing, improves bone growth around the implant and strengthens the attachment and integration of the implant to the bone.
Integrins as receptors give insight into rotavirus and diarrhea
Eleven years ago, Dr. Mary Estes of Baylor College of Medicine and her colleagues discovered the first viral enterotoxin, rotavirus NSP4, a toxic protein that affects the intestines, causing diarrhea.
Cell surface receptors are all 'talk' in T cell stimulation
Understanding the mechanisms that drive healthy immune responses is important when it comes to combating autoimmune diseases, which occur when cells that should attack invading organisms turn on the body instead.
Researchers find new way to block destructive rush of immune cells
Researchers have found a way to selectively block the ability of white blood cells to "crawl" toward the sites of injury and infection when such mobility drives disease, according to a study published today in The Journal of Experimental Medicine.
UCSD researchers create roadmap to integrin activation
Calling it an important technical advance in the study of the complex receptors and pathways of the body's cellular system, researchers at the University of California, San Diego (UCSD) School of Medicine have reconstructed the signaling pathways that impact activation of a receptor that is critical to the control of bleeding and to the thrombosis that occurs in heart attacks and strokes.
More Integrins Current Events and Integrins News Articles
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Domain I Integrins by Donald E., Ph.D. Gullberg (Editor) | |
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Signal Transduction by Integrins by Paola Defilippi (Author), Guido Tarone (Author), Angela Gismondi (Author), A. Santoni (Author) Univ. of Torino, Italy. Summary of the literature available on integrin signaling. DNLM: Integrins--physiology. |
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Integrins and Icam-1 in Immune Responses (Chemical Immunology) (v. 50) by Nancy Hogg (Author) The regulation of cell adhesion is a prerequisite for establishing and maintaining a normal host defence system. One of the main classes of molecules mediating cellular adhesive interactions is the integrin, a broadly distributed family of transmembrane receptors. This book offers an overview of the structure and function of a number of integrins and also of intercellular adhesion molecule-1(ICAM-1). Topics covered include the regulation of leukocyte integrin function, the role of VLA integrins in lymphocyte migration and recognition, common and ligand-specific integrin recognition mechanisms, and the role of integrin alpha-481 in lymphocyte-endothelial cell interactions. The second part of the book highlights the importance of ICAM-1, an immunoglobulin and ligand for the leukocyte... | |
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Integrin-mediated Interactions between Cells and Biomimetic Materials by Dr. Robert Knerr (Author) Based on the idea of self-assembled monolayers of alkanethiols on gold, it was the goal of this thesis to develop a versatile model system for an efficient and straightforward characterization of cell - biomaterial interactions on PEG-rich surfaces. The necessary compounds for this model system should allow for mimicking the surface of polymeric poly(ethylene glycol)-rich biomaterials used for the design of cell carriers. By evaluating the adsorption of proteins and the adhesion characteristics of mammalian cells on these artificial surfaces, conclusions can be drawn, on how polymers should be engineered to achieve an optimal adhesion, growth or proliferation of cells. In particular, the consequences of an attachment of peptidic cell adhesion peptides and growth factors had to be... |
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The Role of B1-Integrins in Skeletal Muscle Differentiation and Extracellular Matrix Assembly (Comprehensive Summaries of Uppsala Dissertations, 939) by Lars Lohikangas (Author) | |
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Anti-integrins likely to impact dermatology. (First Due Later this Year).(Brief Article): An article from: Skin & Allergy News by Bruce Jancin (Author) This digital document is an article from Skin & Allergy News, published by International Medical News Group on April 1, 2002. The length of the article is 542 words. The page length shown above is based on a typical 300-word page. The article is delivered in HTML format and is available in your Amazon.com Digital Locker immediately after purchase. You can view it with any web browser. Citation Details Title: Anti-integrins likely to impact dermatology. (First Due Later this Year).(Brief Article) Author: Bruce Jancin Publication: Skin & Allergy News (Magazine/Journal) Date: April 1, 2002 Publisher: International Medical News Group Volume: 33 Issue: 4 Page: 36(1) Article Type: Brief Article Distributed by Thomson... | |
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Competitor Analysis: Integrin Antagonists by La Merie S.L. (Author) The Competitive Intelligence Report Integrin Antagonists as of June 2008 provides a competitor analysis in the development pipeline of novel treatments of a series of indications such as Crohn’s disease, multiple sclerosis, acute coronary syndrome, cancer, AMD, rheumatoid arthritis. Integrin targets include alpha4/beta1/7, alphaV/beta3/5, alpha5/beta1, VLA4 and others. Among the companies active in the field of new integrin antagonists are Biogen Idec and Elan, Roche, GlaxoSmithKline, J&J, Pfizer, Eisai and many others. The report includes a compilation of current active projects in research and development of novel integrin antagonists. Competitor projects are listed in a tabular format providing Information on: Drug Codes, Target / Mechanism of Action, ... | |
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I Domains in Integrins (Molecular Biology Intelligence Unit) by Donald Gullberg (Editor) In vertebrates, the integrin family includes 24 members. As the alpha-chains were sequenced, some were observed to have an inserted domain similar to the A domain in several matrix and complement proteins. This inserted ligand binding domain is interactive and was called the I domain in integrins. More recently structural data have shown that an integrin beta-chain also contains an I domain. Nine of the currently known 18 alpha-chains contain an I domain. This book systematically goes through the current knowledge about these integrins, including the newest additions to the integrin family, the collagen-binding alpha10beta1 and alpha11beta1 integrins. The book discusses ligand binding, signalling properties, knock-out phenotypes and possible involvement in disease. This book... |
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Integrins: Molecular and Biological Responses to the Extracellular Matrix (Biology of Extracellular Matrix) by David A. Cheresh (Editor), Robert P. Mecham (Editor) Integrins: Molecular and Biological Responses to the Extracellular Matrix will help basic, applied, and clinical researchers keep up with the explosion of literature on the integrin family of proteins. This volume extends material previously covered in Receptors for Extracellular Matrix. It addresses some of the most exciting areas of integrin biology, including the varied roles of integrins in cell division, differentiation, movement, wound healing, inflammation, thrombosis, osteoporosis, and cancer. Key Features * Describes key aspects of integrin structure, function, and biology * Covers collagen receptors, epithelial cell integrins, leukocyte integrins, platelet integrins, integrin signaling, and integrin antagonists *... |
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Diverse Roles of Integrin Receptors in Articular Cartilage (Advances in Anatomy, Embryology and Cell Biology) by M. Shakibaei (Author), C. Csaki (Author), A. Mobasheri (Author) Integrins are heterodimeric integral membrane proteins made up of a and ß subunits. At least 18 a and 8 ß subunit genes have been described in mammals. Integrin family members are plasma membrane receptors involved in cell adhesion and active as intra- and extracellular signalling molecules in a variety of processes including embryogenesis, hemostasis, tissue repair, immune response and metastatic spread of tumor cells. Integrin beta 1 (ß1-integrin) the protein encoded by the ITGB1 gene (also known as CD29 and VLAB) is a multi-functional protein involved in cell-matrix adhesion, cell signalling, cellular defense, cell adhesion, protein binding, protein heterodimerization and receptor-mediated activity. It is highly expressed in the human body (17.4 times higher than the average gene... |
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