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What is the pathogenesis of liver damage induced by ethanol?
October 08, 2008They investigated the effects of ethanol on the IGF-I system with the involvement of JNK1/2 activity and ADH by using each chemical inhibitor in primary cultured rat hepatocytes. The results indicate that ethanol inducedp-JNK1/2 activation is associated with the IGF-I system and cell viability in hepatocytes. Furthermore, alcohol dehydrogenase is involved in the relationship between ethanol-induced inactivation of p-JNK1/2 and the changes of the IGF-I system and cell viability.
Body of text: Insulin-like growth factor (IGF)-I is a peptide that plays an important role in regulating metabolism, growth, and differentiation. Although the relationships between ethanol-induced cellular action and apoptosis via MAPK including JNK1/2 activity have been reported previously, the secretory mechanism by which the IGF-I system (IGF-I secretion, IGF-I mRNA expression, and IGF-IR activity) remains to be elucidated in primary cultured hepatocytes.
A research article to be published on January 28, 2008 in the World Journal of Gastroenterology addresses this question. Using Radioimmunoassay, RT-PCR, MTT assay, and Westernblotting, the authors investigates the relationship of IGF-I system and JNK1/2 as well as ADH activity by adding specific JNK1/2 and ADH inhibitor during ethanol exposure.
Their main findings are: (1) ethanol transiently increased p-JNK1/2 activity at 60 min and then decreased it at 180 min. (2) ethanol-induced transient activation of p-JNK1/2 increased in the IGF-I system, but this decreased when p-JNK1/2 was inactivated. Furthermore, IGF-IR activity also regulates ethanol-induced secretion and synthesis of IGF. (3) Cell viability is decreased via ADH by ethanol. These findings might be helpful to understand the pathogenesis of liver damage induced by ethanol, and may lead to a rational therapeutic intervention against ethanol toxicity.
World Journal of Gastroenterology
Their main findings are: (1) ethanol transiently increased p-JNK1/2 activity at 60 min and then decreased it at 180 min. (2) ethanol-induced transient activation of p-JNK1/2 increased in the IGF-I system, but this decreased when p-JNK1/2 was inactivated. Furthermore, IGF-IR activity also regulates ethanol-induced secretion and synthesis of IGF. (3) Cell viability is decreased via ADH by ethanol. These findings might be helpful to understand the pathogenesis of liver damage induced by ethanol, and may lead to a rational therapeutic intervention against ethanol toxicity.
World Journal of Gastroenterology
Ethanol Current Events and Ethanol News RSSDelft breakthrough in bioethanol production from agricultural waste
With the introduction of a single bacterial gene into yeast, researchers from Delft University of Technology in the Netherlands achieved three improvements in bioethanol production from agricultural waste material: 'More ethanol, less acetate and elimination of the major by-product glycerol' This week the invention was published in the scientific journal Applied and Environmental Microbiology.
Flax and yellow flowers can produce bioethanol
Surplus biomass from the production of flax shives, and generated from Brassica carinata, a yellow-flowered plant related to those which engulf fields in spring, can be used to produce bioethanol.
UT Knoxville and ORNL researchers turn algae into high-temperature hydrogen source
In the quest to make hydrogen as a clean alternative fuel source, researchers have been stymied about how to create usable hydrogen that is clean and sustainable without relying on an intensive, high-energy process that outweighs the benefits of not using petroleum to power vehicles.
Wet ethanol production process yields more ethanol and more co-products
Using a wet ethanol production method that begins by soaking corn kernels rather than grinding them, results in more gallons of ethanol and more usable co-products, giving ethanol producers a bigger bang for their buck - by about 20 percent.
Scripps team shows diet switching can activate brain's stress system, lead to 'withdrawal' symptoms
In research that sheds light on the perils of yo-yo dieting and repeated bouts of sugar-bingeing, researchers from The Scripps Research Institute have shown in animal models that cycling between periods of eating sweet and regular-tasting food can activate the brain's stress system and generate overeating, anxiety, and withdrawal-like symptoms.
UC Riverside Researchers Create First Synthetic Cellulosome in Yeast
A team of researchers led by University of California, Riverside (UCR) Professor of Chemical Engineering Wilfred Chen has constructed for the first time a synthetic cellulosome in yeast, which is much more ethanol-tolerant than the bacteria in which these structures are normally found.
Propolis has proved to be a product with ability to have beneficial effects for health
Growing concerns about health has caused the scientific community to focus their interest on investigating functional foods which contribute to boosting the prevention and reduction of the risk of suffering from certain illnesses.
Standards for a new genomic era
A team of geneticists at Los Alamos National Laboratory, together with a consortium of international researchers, has recently proposed a set of standards designed to elucidate the quality of publicly available genetic sequencing information.
0.2 second test for explosive liquids
Since a failed terrorist attack in 2006, plane passengers have not been able to carry bottles of liquid through security at airports, leaving some parched at the airport and others having expensive toiletries confiscated, but work by a group of physicists in Germany is paving the way to eliminate this necessary nuisance.
Report examines hidden costs of energy production and use
A new report from the National Research Council examines and, when possible, estimates "hidden" costs of energy production and use -- such as the damage air pollution imposes on human health -- that are not reflected in market prices of coal, oil, other energy sources, or the electricity and gasoline produced from them.
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OZOFire Bio-Ethanol Liquid Fuel for Fireplaces 6pk of 1 quart bottles by Anywhere Fireplace OZOFireTM was created especially for Indoor Ventless Fireplaces and is totally safe for you and the planet. It is a clean, sustainable Bio-Ethanol fuel specially formulated to provide the cleanest fire possible while complying with all regulations required by U.S. Government Agencies. The only byproducts created when burning OZOFireTM fuel are water vapor and very small amounts of carbon dioxide; no toxins or offensive fumes are emitted. The flame is clean and odorless. OZOFireTM burns efficiently and there is no oily residue left in the tank as with other Bio-Ethanol fuels which contain petroleum distillates. |
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Bel-Art F116463732 1000ml Safety Wide Mouth Wash Bottle Labeled Ethanol by Bel-Art BEL-ARTS safety labeled wash bottles ensure leak proof dispensing of your most common solvents in the laboratory. The low density polyethylene bottles and polypropylene caps are chemical and corrosion resistant. Bottles are imprinted with DOT, NFPA, CAS, protective equipment and target organ information and symbols. Contains 6 per bag and are convenient for controlled dispensing. Label: Ethanol Size: 1000ml (32oz) |
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