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Burnham Researchers Turn Cancer Friend into Cancer Foe
October 08, 2008Burnham Institute for Medical Research today announced that scientists have created a peptide that binds to Bcl-2, a protein that protects cancer cells from programmed cell death, and converts it into a cancer cell killer. The research, which was published as the featured article in the October 7 edition of Cancer Cell, may lead to new cancer treatments.
The Bcl-2 protein has long been implicated in protecting cancer cells from apoptosis (programmed cell death), the process that usually keeps cancer cells in check. This peptide (called NuBCP-9) and its enantiomer (mirror-image molecule) work on Bcl-2 like a molecular switch, converting it into a pro-apoptotic protein, and inducing cell death in cancer cells.
"Our results provide insight into Bcl-2 conversion and identify a new direction for Bcl-2-based drug leads and cancer drug development," said Xiao-kun Zhang, Ph.D., who co-authored the paper with Arnold Satterthwait, Ph.D. and others.
The NuBCP-9 peptide was created from Nur77, a potent pro-apoptotic protein. Nur77 often moves from the nucleus to mitochondria, in response to different death signals, where it binds to Bcl-2, changing its shape and function.
Burnham Institute for Medical Research
The NuBCP-9 peptide was created from Nur77, a potent pro-apoptotic protein. Nur77 often moves from the nucleus to mitochondria, in response to different death signals, where it binds to Bcl-2, changing its shape and function.
Burnham Institute for Medical Research
Cell Death Current Events and Cell Death News RSSSweet -- sugared polymer a new weapon against allergies and asthma
Scientists at Johns Hopkins and their colleagues have developed sugar-coated polymer strands that selectively kill off cells involved in triggering aggressive allergy and asthma attacks.
UAB Researchers Discover Antibody Receptor Identity, Propose Renaming Immune-System Gene
Researchers at the University of Alabama at Birmingham (UAB) have uncovered the genetic identity of a cellular receptor for the immune system's first-response antibody, a discovery that sheds new light on infection control and immune disorders.
Inhibition of GRK2 is protective against acute cardiac stress injuries
Inhibition of a protein known to contribute to heart failure also appears to be protective of the heart in more acute cardiac stress injury, namely ischemia reperfusion.
Researchers find potential treatment for Huntington's disease
Investigators at Burnham Institute for Medical Research (Burnham), the University of British Columbia's Centre for Molecular Medicine and Therapeutics and the University of California, San Diego have found that normal synaptic activity in nerve cells (the electrical activity in the brain that allows nerve cells to communicate with one another) protects the brain from the misfolded proteins associated with Huntington's disease.
Research reveals lipids' unexpected role in triggering death of brain cells
The lipid that accumulates in brain cells of individuals with an inherited enzyme disorder also drives the cell death that is a hallmark of the disease, according to new research led by St. Jude Children's Research Hospital investigators.
Cornell researchers identify a weak link in cancer cell armor
The seeming invincibility of cancerous tumors may be crumbling, thanks to a promising new gene therapy that eliminates the ability of certain cells to repair themselves.
Sponges recycle carbon to give life to coral reefs
Coral reefs support some of the most diverse ecosystems on the planet, yet they thrive in a marine desert. So how do reefs sustain their thriving populations?
Aileron collaborates study in Nature: Stapled peptides inhibit Notch1 transcription factor
This research validates the potential for Stapled Peptides to modulate key intracellular biological targets, such as transcription factors, that have not been addressable with current small molecule or biologic drug modalities.
CSHL team solves structure of NMDA receptor unit that could be drug target for neurological diseases
A team of scientists at Cold Spring Harbor Laboratory (CSHL) reports on Thursday their success in solving the molecular structure of a key portion of a cellular receptor implicated in Alzheimer's, Parkinson's, and other serious illnesses.
'Escaped' proteins add to hearing loss in elderly, UF researchers find
Age-related hearing loss is the most common sensory disorder among the elderly. But scientists are still trying to figure out what cellular processes govern or contribute to the loss.
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Cell 2455, Death Row: A Condemned Man's Own Story by Caryl Chessman (Author), Joseph Longstreth (Introduction) In June 1948, 27-year-old petty criminal Caryl Chessman was sentenced in California on two counts of sexual assault, receiving two death sentences as punishment in a case that remains one of the most baffling episodes in American legal history. Maintaining his innocence of these crimes, Chessman lived in Cell 2455, a four-by-ten foot space on Death Row in San Quentin for the twelve years between his sentencing and eventual execution. He spent this time, punctuated by eight separate stays of execution, writing this memoir — a moving and pitiless account of his life in crime and the early life that produced it. Chessman's clarity of mind and ability to bring his thoughts directly to the page, even within the stifling walls of San Quentin, help make this work the most literate and... |
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Death Note: Cell Phone Strap - SD L Charm by GE BRAND NEW |
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Death Note : Apple Charm with Chibi Light and L Lanyard by GE This Death Note Lanyard features images of Chibi Light and L. An apple charm is also attached. |
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Death Note: Cell Phone Strap - Ryuk Earrings Charm by GE BRAND NEW |
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Death Cell Blues - Mary Johnson Mary Johnson (Primary Contributor) |
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Death Note: Cell Phone Charm - Sexy Misa by GE The Death Note strap set has a Misa charm and other small charms attached. |
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The Music of Don Freund, Vol. 1 Don Freund (Composer), David Dzubay (Composer), Don Freund (Composer), Indiana University New Music Ensemble (Composer), Indiana University Concert Orchestra (Composer), Moira Smiley (Composer), Atar Arad (Composer) |
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Death Cell Also With: Art Clokey (Producer), Ralph Smart (Producer) |
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Samsung Cell Phone A877 Impression Shell/Faceplates (Death Skull) for Samsung SGH-a877 Impression + Free Antenna Booster by Talon •There's no need to remove the phone's original body. •Phone shells come in many different colors and designs making it easy to personalize and stylized your phone. •Phone shells are hard plastic snap-on covers that protect your phone's body from typical wear and tear. •The cases are easy to install. Generally, you snap on the pieces over the phone's existing body. •Because each case is specifically molded to fit each specific phone model, all features of the phone are fully accessible with the case on. •Access the phone's buttons, camera, and ports without having to remove the phone from the case. |
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Cell 2455 Death Row - Movie Poster - 11 x 17 by Pop Culture Graphics MovieGoods has Amazon's largest selection of movie and TV show memorabilia, including posters, film cells and more: tens of thousands of items to choose from. We also offer a full selection of framed posters. Customer satisfaction is always guaranteed when you buy from MovieGoods on Amazon at www.amazon.com/moviegoods |
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