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A low-cholesterol diet leaves a bitter taste in the gut
October 10, 2008One role for the proteins on the tongue that sense bitter tasting substances, type 2 taste receptors (T2Rs), is to limit ingestion of these substances, as a large number of natural bitter compounds are known to be toxic. T2Rs are also found in the gut, and it has been suggested that there they have a similar role to their function in the mouth (i.e., they might limit intestinal toxin absorption). Data to support this idea has now been generated in mice by Timothy Osborne and colleagues, at the University of California, Irvine.
By supplementing the food that mice eat with the drugs lovastatin and ezetimibe (L/E), it is possible to reduce the amount of cholesterol that they take up, and they are therefore considered to be consuming a low-cholesterol diet. Such a diet increases the activity of the protein SREBP-2 in the gut.
In this study, SREBP-2 was shown to directly induce the expression of T2Rs in cultured mouse intestinal cells as well as in the intestine of mice consuming food supplemented with L/E. In addition, SREBP-2 was shown to directly enhance T2R-induced secretion of the intestinal peptide cholecystokinin in both the cultured mouse intestinal cells and mice consuming food supplemented with L/E. As low-cholesterol diets are naturally composed of high amounts of plant matter that is likely to contain dietary toxins, and one function of cholecystokinin is to decrease food intake, the authors suggest that SREBP-2-induced expression of T2Rs might provide a mechanism both to inform the gut that food-borne toxins could be present and to initiate a response that limits their absorption
Journal of Clinical Investigation
Journal of Clinical Investigation
Intestinal Cells Current Events and Intestinal Cells News RSSAlcohol activates cellular changes that make tumor cells spread
Alcohol consumption has long been linked to cancer and its spread, but the underlying mechanism has never been clear.
Probiotic Found to Be Effective Treatment for Colitis In Mice
The probiotic, Bacillus polyfermenticus, can help mice recover from colitis, a new study has found.
Model backs green tea and lemon claim, lessens need to test animals
An animal study at Purdue University has shown that adding ascorbic acid and sugar to green tea can help the body absorb helpful compounds and also demonstrates the effectiveness of a model that could reduce the number of animals needed for these types of studies.
Designing probiotics that ambush gut pathogens
Researchers in Australia are developing diversionary tactics to fool disease-causing bacteria in the gut.
Magic ingredient in breast milk protects babies' intestines
Scientists at Queen Mary, University of London have discovered that an ingredient in human breast milk protects and repairs the delicate intestines of newborn babies.
Intestinal cells surprisingly active in pursuit of nutrition and defense
Every cell lining the small intestine bristles with thousands of tightly packed microvilli that project into the gut lumen, forming a brush border that absorbs nutrients and protects the body from intestinal bacteria.
Technique eradicates problems in most patients with Barrett's esophagus
A procedure that uses heat generated by radio waves to treat Barrett's esophagus, a condition caused by acid reflux (severe heartburn), can eliminate signs of the potentially cancer-causing disorder and reduce the risk that the disease will progress.
Bacteria with a built-in thermometer
Researchers in the "Molecular Infection Biology group" at the Helmholtz Centre for Infection Research (HZI) in Braunschweig and the Braunschweig Technical University could now demonstrate for the first time that bacteria of the Yersinia genus possess a unique protein thermometer - the protein RovA - which assists them in the infection process.
Details of bacterial 'injection' system revealed
New details of the composition and structure of a needlelike protein complex on the surface of certain bacteria may help scientists develop new strategies to thwart infection.
Natural protein may halt colorectal cancer's spread
Medical College of Wisconsin Cancer Center researchers in Milwaukee have learned that a protein, CXCL12, that normally controls intestinal cell movement, has the potential to halt colorectal cancer spreading.
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BCAA, Branched Chain Amino Acids 120 Caps - Provided by Physician Formulas by Jarrow L-Leucine L-Isoluecine L-Valine L-Glutamine BCAA Complex contains the ideal 2:1:1 ratio of the free-form, crystalline branched chain amino acids L-Leucine, L-Isoleucine and L-Valine combined with the conditionally essential amino acid L-Glutamine. The higher amount of Leucine reflects it's importance in muscle metabolism as the most effective branch chain amino acid for stimulation of protein synthesis and it is more readily utilized for energy. BCAA's exert an anticatabolic effect by reducing the breakdown of protein, thereby protecting muscle tissue. Glutamine is a preferred source of fuel for the intestinal cells and is in high demand by skeletal muscles following physical exertion. Vitamin B6 enhances amino acid metabolism. |
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L-Glutamine 500mg - 50 - Veg/Cap by Solgar Amino acids are the building blocks of protein. In fact, the daily protein requirement is really the body s need for amino acids. Dietary amino acids are classified as essential and non-essential. Both are used to assemble hormones, enzymes neurotransmitters (chemical messengers), antibodies, and nutrient carriers. L-Glutamine is a major fuel source for intestinal, immune, and brain cells. L-Glutamin comprises 60% of the body s total amino acid muscle pool and is the highest concentrated amino acid in the blood stream. It is responsible for transporting nitrogen to tissues and removing nitrogen from the body. It is also important in regulating amino acid balance. Solgar's L-Glutamine Vegetable Capsules are free of corn, yeast, wheat, soy and dairy products and are formulated without the... |
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