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The risk factors of abdominal venous thrombosis
October 13, 2008Abdominal venous thrombosis may present as BCS or SVT. Hereditary and acquired risk factors have been implicated in the etiopathogenesis of abdominal venous thrombosis. Hereditary risk factors for thrombophilia include Factor V Leiden gene mutation, Prothrombin gene mutation, homozygous methyl tetrahydrofolate reductase (MTHFR) gene mutation and deficiencies of coagulation inhibitor Protein C, Protein S and Antithrombin III. There are few studies from South Asian region which have comprehensively evaluated prothrombotic risk factors in BCS and PVT.
A research article to be published on July 28, 2008 in the World Journal of Gastroenterology addresses this question. The research team led by Prof. Ashok Chacko at the Christian Medical College & Hospital, Vellore, India investigated the inherited and acquired risk factors causing clotting of blood in abdominal veins.
Thirty-six patients with blood clots in abdominal veins were studied. The patients were divided into BCS group and SVT group based on the veins involved. Twenty patients had SVT, 14 had BCS and 2 had mixed venous involvement. Inherited and acquired risk factors for blood clotting were evaluated in all patients. Overall, 10 patients (28%) had inherited and 10 patients (28%) acquired risk factors. The acquired risk factors were significantly more common in the SVT group while inherited risk factors though higher than controls did not show significant difference between the two groups. Multiple risk factors were present in one (7%) patient with BCS and 3 patients (15%) with SVT. No risk factors were identified in 57% of patients with BCS and 45% of patients with SVT.
Their result indicate that hereditary and acquired risk factors play an important role in etiopathogenesis of abdominal venous hrombosis. Acquired risk factors are significantly more common in patients with SVT while hereditary risk factors are similar in patients with BCS and SVT. Recognition and evaluation of these risk factors may help in therapy and prevention of disease progression. As a significant number of patients lack obvious etiology further research is required to identify as yet unrecognized risk factors.
World Journal of Gastroenterology
Their result indicate that hereditary and acquired risk factors play an important role in etiopathogenesis of abdominal venous hrombosis. Acquired risk factors are significantly more common in patients with SVT while hereditary risk factors are similar in patients with BCS and SVT. Recognition and evaluation of these risk factors may help in therapy and prevention of disease progression. As a significant number of patients lack obvious etiology further research is required to identify as yet unrecognized risk factors.
World Journal of Gastroenterology
Venous Thrombosis Current Events and Venous Thrombosis News RSSClots traveling from lower veins may not be the cause of pulmonary embolism in trauma patients
A report from a team of Massachusetts General Hospital (MGH) physicians calls into question the longstanding belief that pulmonary embolism (PE) - the life-threatening blockage of a major blood vessel in the lungs - is caused in trauma patients by a blood clot traveling from vessels deep within the legs or lower torso.
Blood clots in lungs might not always originate in deep veins of legs and pelvis in trauma patients
Few trauma patients who develop potentially deadly blood clots in the lungs (pulmonary embolism) also have clots in the deep veins of their pelvis and legs (deep venous thrombosis), challenging commonly held beliefs about the association between the two conditions.
Image-guided treatment for deep venous thrombosis could improve patients' long-term outcomes
Deep Venous Thrombosis (DVT) is a serious condition that involves the formation of a blood clot inside of a deep vein usually in the legs. A patient with DVT is typically treated with anticoagulants (blood thinners) however researchers have found that image-guided interventional radiology procedures may play a more central role in the long-term treatment of DVT.
Study explains potential failure of oral contraceptives with obese women
Researchers have identified a potential biological mechanism that could explain why oral contraceptives may be less effective at preventing pregnancy in obese women, as some epidemiological studies have indicated.
ESC reaffirms advice on cardiovascular risks associated with long-haul flights
Dr Steen Kristensen, Vice-president of the ESC, says: "Long distance flying is associated with an increase in deep venous thrombosis, which in some cases may lead to clotting of the lungs. People who are immobile, pregnant, taking contraceptive pills or have had venous thrombosis in the past are particularly at risk.
Research highlights new approaches to prevent blood clots
Blood clotting, or coagulation, is an important process that prevents excessive bleeding when a blood vessel is injured.
Thrombosis patients face greater risks than previously believed
Deep venous thrombosis (DVT), the formation of blood clots in the lower limbs, is the third-most common vascular disease in North America after heart attack and stroke, and is a frequent complication in hospitalized patients.
AJN study reveals compression stockings incorrectly used in 29 percent of patients
An original study, published in the September issue of the American Journal of Nursing (AJN), revealed that graduated compression stockings were used incorrectly in 29% of the patients and sized incorrectly in 26% of the patients.
Study finds it pays to be heart smart if considering hormone therapy
A research study has found that a simple blood test may indicate whether post-menopausal hormone therapies present an elevated risk of a heart attack.
Study examines long-term outcomes following blood clots
Patients who develop a blood clot in their legs (deep vein thrombosis) or lungs (pulmonary embolism) are at risk for experiencing another blood clot within three years, and patients with pulmonary embolism have a higher risk of death.
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