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How to differentiate macro-regenerative nodules from hepato-carcinoma?
October 13, 2008BA, the congenital absence or destruction of intra- or extra-hepatic biliary system, affects about 5 - 10/100 000 live births. End stage liver cirrhosis developed in some BA patients later in life. As a result of liver cirrhosis, regenerative nodules may develop in cirrhotic liver including a specific type termed MRN. The clinical significance and pathological features of MRN have been discussed in some articles. However, the image features of MRN and how to differentiate them from HCC have yet to be elucidated.
A research article to be published on July 28, 2008 in the World Journal of Gastroenterology addresses this question. The research team led by Dr. Yu-Fan Cheng from Chang-Gung memorial hospital- Kaohsiung medical center found that MRN developed in about 5% BA patients and there was no malignant change within them based on the histopathological finding of 144 extracted livers. The authors also reviewed pre-transplantation image surveys including CT and MRI.
They found that the MRN may have typical and atypical images features in CT/MRI. Typical MRN which are found in about 5/8 are hyperdense on pre-contrast CT and hypointense on T2WI MRI as compared with surrounding liver parenchyma. They had intra-tumoral tubular vascular bundles and showed no enhancement. These features can be used to differentiate from HCC. Atypical MRN which are found in 3/8 showed arterial enhancement and may be interpreted as signs of malignant change. Liver biopsy may aid in making a decision before liver transplantation (LT).
LT should not be withheld in BA patients based solely on images because benign lesions may also have images which look like HCC. The combined use of alfa-feto-protein , images and sometimes liver biopsy are still helpful in pre-transplant survey. The result of this article implies that liver biopsy can be avoided if supported by the typical images of MRN and repeated biopsy is not necessary if the AFP value is incongruent with radiographic findings.
World Journal of Gastroenterology
LT should not be withheld in BA patients based solely on images because benign lesions may also have images which look like HCC. The combined use of alfa-feto-protein , images and sometimes liver biopsy are still helpful in pre-transplant survey. The result of this article implies that liver biopsy can be avoided if supported by the typical images of MRN and repeated biopsy is not necessary if the AFP value is incongruent with radiographic findings.
World Journal of Gastroenterology
Liver Cirrhosis Current Events and Liver Cirrhosis News RSSThe use of stem cells in regenerative medicine may also be detrimental for health
The use of stem cells in regenerative medicine is not always beneficial for human health, it may even be harmful according to a work done by the University of Granada and University of León. Scientists have demonstrated that transplantation of human mononuclear cells isolated from umbilical cord blood exerted a deleterious effect in rats with liver cirrhosis.
Discovery could improve hepatitis C treatment
Walter and Eliza Hall Institute researchers are part of an international team that has discovered a genetic variation that could identify those people infected with hepatitis C who are most likely to benefit from current treatments.
What are the risk factors for rebleeding after negative angiography?
Acute non-variceal gastrointestinal bleeding accounts for approximately 20% of emergency room visits and 5% of admissions.
HBV genotype B/B3 and C/C1 are the major genotypes in Indonesia?
Previous studies revealed that HBV genotypes as well as mutations in the core promoter, precore or HBx gene have been shown to have an association with the clinical outcome of liver disease, however, this is still controversial.
New Strategy for Inhibiting Virus Replication
Viruses need living cells for replication and production of virus progeny. Thus far, antiviral therapy primarily targets viral factors but often induces therapy resistance. New improved therapies attempt to targets cellular factors that are essential for viral replication.
Spot urine test: To monitor dietary sodium compliance in liver disease patients?
A research article to be published on August 7 , 2009 in the World Journal of Gastroenterology addresses this question.
Hepatitis C infection: treatment options equally effective, likelihood of success known early on
Results of a long-awaited study of 3,070 American adults at Johns Hopkins and 118 other U.S. medical centers show that treatment with either of the two standard antiviral drug therapies is safe and offers the best way for people infected with hepatitis C to prevent liver scarring, organ failure and death.
Study shows 1 in 25 deaths worldwide attributable to alcohol
Research from Canada's own Centre for Addiction and Mental Health (CAMH) featured in this week's edition of the Lancet shows that worldwide, 1 in 25 deaths are directly attributable to alcohol consumption.
An alternative treatment for hypervascular hepatocellular carcinoma
HCC is the fifth most common cancer in the world and the third most frequent cause of cancer-related death. Only about 20% of HCC patients are eligible for surgical resection.
What is the relationship between hepatocellular carcinoma and type 2 diabetes mellitus?
Hepatocellular carcinoma (HCC) is the fifth most common malignancy worldwide and the third leading cause of cancer-related deaths.
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The First Year: Cirrhosis: An Essential Guide for the Newly Diagnosed (First Year, The) by James L. Dickerson (Author), Fredric Regenstein (Foreword) More than 25 million Americans and 92 million worldwide suffer from liver disease and cirrhosis, a degenerative and potentially fatal condition in which liver cells are damaged and then replaced by scar tissue, impeding liver function. The disease is most commonly caused by excessive alcohol consumption, hepatitis, or complications from prescription drugs. Immediately after his diagnosis, James Dickerson set out to educate himself on all of his options — and found there is hope for recovery. Now, he offers The First Year: Cirrhosis, the first guide for patients and their families to understanding and managing this chronic condition. In clear, accessible language, the book walks readers step-by-step through everything they need to do each day of the first week after a cirrhosis... |
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FlameEz-Liver, 60 Capsules/Bottle by FlameEz There are many types of liver disease. Whether the liver is infected with a virus or injured by chemicals, the process of the liver damage always involves inflammation. If properly treated, the inflammation may go away and the liver can heal itself. If left untreated, the inflamed liver will start to scar. As excess scar tissue grows, it replaces healthy liver tissue and leads to fibrosis or cirrhosis. Although it is important to treat the liver disease in the inflammation and fibrosis stages, the treatment choice is limited because many drugs are metabolized by the liver and a few drugs that are used routinely to treat liver disease have significant side effects. Natural remedies are available as alternative approach for liver disease. FlameEz-Liver is a high quality natural liver... |
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Cirrhosis Liver Specimen Photographic Poster Print, 16x12 by AllPosters.com AllPosters.com is the world's #1 seller of posters, prints, photographs, specialty products and framed art. We're dedicated to bringing our customers the best selection of high quality wall décor that is perfect for their home or office. Browse our catalog of over 300,000 items that include entertainment and specialty posters, decorative prints, and art reproductions. Whether you're looking for your favorite movie or music poster, a framed Monet reproduction, or a print of the Eiffel Tower you will find it at AllPosters.com. Visit our Amazon store today at www.amazon.com/allposters to find Special Offers and search by subject category or artist. AllPosters.com provides unmatched service with a 100% satisfaction guarantee. We ship internationally to over 80 countries. Decorate your... |
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The Official Patient's Sourcebook on Cirrhosis of the Liver: A Revised and Updated Directory for the Internet Age by ICON Health Publications (Author) This book has been created for patients who have decided to make education and research an integral part of the treatment process. Although it also gives information useful to doctors, caregivers and other health professionals, it tells patients where and how to look for information covering virtually all topics related to cirrhosis of the liver (also liver cirrhosis), from the essentials to the most advanced areas of research. The title of this book includes the word official. This reflects the fact that the sourcebook draws from public, academic, government, and peer-reviewed research. Selected readings from various agencies are reproduced to give you some of the latest official information available to date on cirrhosis of the liver. Given patients' increasing sophistication in using... |
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Diseases of the Digestive System Anatomical Chart, Flexible Laminated by Anatomical Diseases of the Digestive System Anatomical Chart illustrates a wide variety of diseases such as: Cancers of the esophagus, Esophageal varices, Cirrhosis, Fatty liver, Hepatitis, Gallstones, Gastric and duodenal ulcers, Adenocarcinoma of stomach and pancreas, Gastritis, Pancreatitis, Cancers of the colon, Colonic polyps, Diverticulitis of the colon, Inflammatory Bowel Disease, Appendicitis, Hernia, Hemorrhoids, Size is 20" W by 26" H. |
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Alfa Vitamins Liverex 60 caps Detox Normalize Protect Liver Health by Alfa Vitamins The liver plays a major role in the body's metabolism and participates in a number of important body functions, including drug detoxification, glycogen storage, and plasma protein synthesis. It also produces bile, which is very important for the digestive process. Liverex formula has been developed to maintain and improve liver health, designed with a combination of different herbs and minerals that have been traditionally used to support liver functions, including Milk Thistle, Copper, Magnesium and Spirulina, among others. |
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Native Remedies Liver Dr. for Ongoing Liver Health (50ml) by Native Remedies Liver Dr is a 100% natural, safe and proven herbal remedy for ongoing liver health. Liver Dr. contains herbs known for their ability to maintain healthy liver functioning. It also helps the liver resist damage from toxins and disease, thereby improving overall systemic health. Apart from their beneficial effect on the liver, the herbs chosen for Liver Dr. also have other important therapeutic benefits, which further contribute to a healthy body and better quality of life. Use Liver Dr. to improve functioning of the liver and promote health; prevent problems associated with a sluggish liver; help treat liver disease and prevent further damage to the liver in diseases like viral hepatitis, cirrhosis, fatty liver, hemochromatosis, Alpha-1 antitrypsin deficiency and Wilson¿s disease;... |
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Cirrhosis Liver Specimen Photographic Poster Print, 24x18 by AllPosters.com AllPosters.com is the world's #1 seller of posters, prints, photographs, specialty products and framed art. We're dedicated to bringing our customers the best selection of high quality wall décor that is perfect for their home or office. Browse our catalog of over 300,000 items that include entertainment and specialty posters, decorative prints, and art reproductions. Whether you're looking for your favorite movie or music poster, a framed Monet reproduction, or a print of the Eiffel Tower you will find it at AllPosters.com. Visit our Amazon store today at www.amazon.com/allposters to find Special Offers and search by subject category or artist. AllPosters.com provides unmatched service with a 100% satisfaction guarantee. We ship internationally to over 80 countries. Decorate your... |
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Treatment of Alcoholic Cirrhosis of the Liver with High Vitamin Therap by Arthur J. PATEK (Author) | |
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