 |
|
Why could ethyl pyruvate attenuate severe acute pancreatitis?
October 13, 2008Excessive activation of inflammatory mediator cascade during SAP is a major cause of distant organ injury and the high mortality. Cytokines such as TNF- alpha and IL-1 beta are released early in the development of systemic inflammatory response. This leaves a narrow therapeutic window for administration of therapeutics and delayed delivery of that anti-inflammatory therapeutics is not effective after the inflammatory mediator cascade has developed.
A research article to be published on July 28, 2008 in the World Journal of Gastroenterology addresses this question. The research team led by Prof. Wang from Centre of Pancreatic Surgery of Xiehe Hospital, Tongji Medical College, Huazhong University of Sciecne and Technology, demonstrated that the serum levels of HMGB1 began to rise significantly at 12 h, and maintained at high levels up to 48 h after induction of experimental SAP in rats. The delayed kinetics indicated that HMGB1 may provide a broader therapeutic window for treating this lethal systemic inflammatory disease. EP was proved could inhibit HMGB1 release from macrophages and prevent the accumulation of serum HMGB1 levels in mice with lethal sepsis through inhibiting NF- kappaB and p38 MAPK signaling. The research, performed by this team, investigated whether delayed EP therapy attenuates experimental SAP via reducing serum HMGB1 levels in rats or not.
In this study, EP significantly reduced serum HMGB1 levels in rats with SAP, even though began delivering EP at 12 h after induction of SAP. It also significantly protected against liver, renal and lung injury, and prolonged survival time of rats. Ethyl pyruvate, a stable lipophilic pyruvate derivatives, is a nontoxic food additive. According to this article, EP may serve potentially as an effective and low-cost therapeutic option against the inflammatory response and MODS in SAP patients.
This report is of interest and considerable potential importance because it indicates that delayed treatment of rats with experimental severe acute pancreatitis with ethyl pyruvate is associated with a reduction of HMGB1 levels in blood; a decrease in lung, kidney, and liver injury; and prolonged survival. The "therapeutic window" for inhibiting this inflammatory mediator appears to be more favorable than for some other mediators which more rapidly reach a peak in the blood.
World Journal of Gastroenterology
This report is of interest and considerable potential importance because it indicates that delayed treatment of rats with experimental severe acute pancreatitis with ethyl pyruvate is associated with a reduction of HMGB1 levels in blood; a decrease in lung, kidney, and liver injury; and prolonged survival. The "therapeutic window" for inhibiting this inflammatory mediator appears to be more favorable than for some other mediators which more rapidly reach a peak in the blood.
World Journal of Gastroenterology
Acute Pancreatitis Current Events and Acute Pancreatitis News RSSArterial infusion using gabexate mesilate: Is it effective therapy for severe acute pancreatitis?
Severe acute pancreatitis (SAP) remains a lethal disease. It is defined as an inflammatory process of the pancreas with possible peripancreatic tissue and multi-organ involvement inducing multi-organ dysfunction syndrome (MODS) with an increased mortality rate.
Arterial infusion using gabexate mesilate: Is it effective therapy for severe acute pancreatitis?
Severe acute pancreatitis (SAP) remains a lethal disease. It is defined as an inflammatory process of the pancreas with possible peripancreatic tissue and multi-organ involvement inducing multi-organ dysfunction syndrome (MODS) with an increased mortality rate.
UIC researchers hunting drugs for devastating parasitic disease
Hundreds of millions of people, mainly in developing countries, are disabled by infectious diseases, according to the World Health Organization.
Early surgical treatment contributes to better outcomes in gallstone pancreatitis cases
Although delaying surgical treatment remains the standard of care for patients with severe gallstone pancreatitis, a new study published in the December issue of the Journal of the American College of Surgeons shows that, contrary to widespread belief, early cholecystectomy -- or surgical removal of the gallbladder -- significantly reduces hospital stays in patients with mild to moderate gallstone pancreatitis with no increase in complications or mortality.
Large dose dexamethasone plays important roles in severe acute pancreatitis
Severe acute pancreatitis (SAP) is a fatal systemic disease featuring acute onset, serious conditions, high incidence of complications and 20 - 30% mortality, mainly due to multiple organ failure at its early stage.
Acute pancreatitis and cholangitis: a complication caused by a migrated gastrostomy tube
Percutaneous endoscopic gastrostomy (PEG) is generally considered to be safe with a low rate of serious complications. However, dislocation of a gastrostomy tube can lead to serious complications.
Short-term hemofiltration is cost-effective for severe acute pancreatitis
Early nasogastric enteral nutrition is a breakthrough in the management of severe acute pancreatitis. From meta-analysis based on current available clinical studies early nasogastric enteral nutrition appeared effective and safe in clinical practice.
Method shows promise for early detection of pancreatic cancer
Optical technology developed by a Northwestern University biomedical engineer shown to be effective in the early detection of colon cancer now appears promising for detecting pancreatic cancer, the fourth most common cause of cancer deaths in the United States.
Shining light on pancreatic cancer
Using novel light-scattering techniques, researchers have found the first evidence that early stage pancreatic cancer causes subtle changes in part of the small intestine.
Gene therapy eradicates pancreatic cancer in preclinical trial
A molecularly engineered therapy selectively embeds a gene in pancreatic cancer that shrinks or eradicates tumors, inhibits metastasis, and prolongs survival with virtually no toxicity.
More Acute Pancreatitis Current Events and Acute Pancreatitis News Articles
 | Acute Pancreatitis: Novel Concepts in Biology and Theraphy by Markus Buchler Still frightening to both patients and clinicians, acute pancreatitis is an acute inflammatory disease of the pancreatic gland that may lead to severe systemic response. Fortunately, the knowledge about this disease has increased considerably in the last two decades. On molecular and pathophysiologic bases, doctors do understand more clearly the primary events in the initiation of acute... |
 | Acute Pancreatitis: A Consideration Of Pancreatic Hemorrhage, Hemorrhagic, Suppurative, And Gangrenous Pancreatitis, And Of Disseminated Fat-Necrosis (1889) by Reginald Heber Fitz |
 | Diseases of the Pancreas: Acute Pancreatitis, Chronic Pancreatitis, Tumours of the Pancreas by Waldemar Uhl, Peter Malfertheiner, Michael G. Sarr This title features clearly structured text, presented with the corresponding illustrations on a two-page spread. Compiled by a team of authors with many years' experience in the field of diseases of the pancreas, this book is an ideal combination of evidence-based literature and the authors' expertise. An interdisciplinary approach to the basis, diagnosis and treatment of diseases of the... |
| Incidence of acute pancreatitis on the rise.(Gastroenterology): An article from: Internal Medicine News by Doug Brunk This digital document is an article from Internal Medicine News, published by International Medical News Group on June 15, 2004. The length of the article is 4480 words. The page length shown above is based on a typical 300-word page. The article is delivered in HTML format and is available in your Amazon.com Digital Locker immediately after purchase. You can view it with any web browser.Citation... | |
| Acute Pancreatitis by G. Glazer | |
| Angiotensin-converting enzyme (ACE) inhibitor-induced acute pancreatitis: in search of the evidence.(Editorial): An article from: Southern Medical Journal by Sonal Singh This digital document is an article from Southern Medical Journal, published by Thomson Gale on December 1, 2006. The length of the article is 1248 words. The page length shown above is based on a typical 300-word page. The article is delivered in HTML format and is available in your Amazon.com Digital Locker immediately after purchase. You can view it with any web browser.Citation DetailsTitle:... | |
| Standards in Experimental Acute Pancreatitis (European Surgical Research Supplementum) by M. Buchler | |
| Quick diagnosis crucial in gallstone pancreatitis: gallstones should be suspected in every patient with acute pancreatitis who is also at risk for stones.(Clinical ... An article from: Family Practice News by Betsy Bates This digital document is an article from Family Practice News, published by International Medical News Group on March 15, 2005. The length of the article is 619 words. The page length shown above is based on a typical 300-word page. The article is delivered in HTML format and is available in your Amazon.com Digital Locker immediately after purchase. You can view it with any web browser.Citation... | |
| Acute haemorrhagic pancreatitis;: With remarks on the etiology of chronic pancreatitis by Frederic Samuel Eve | |
| Acute pancreatitis as a manifestation of HIV seroconversion.(Section on Gastroenterology)(Brief Article): An article from: Southern Medical Journal by Sarah Jorgensen, Michael Herman This digital document is an article from Southern Medical Journal, published by Southern Medical Association on October 1, 2004. The length of the article is 305 words. The page length shown above is based on a typical 300-word page. The article is delivered in HTML format and is available in your Amazon.com Digital Locker immediately after purchase. You can view it with any web browser.Citation... |
| © 2009 BrightSurf.com |