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Embryonic heart exhibits impressive regenerative capacity
October 14, 2008A new study demonstrates that the embryonic mouse heart has an astounding capacity to regenerate, a phenomenon previously observed only in non-mammalian species. The research, published by Cell Press in the October 14th issue of the journal Developmental Cell, describes the previously unrecognized potential of the embryonic heart to replace diseased tissue through compensatory proliferation of healthy cells.
Disorders of the mitochondria, a cell structure required for energy production, are one of the leading causes of fatal early onset cardiomyopathies. To investigate how mutations that interfere with mitochondrial function impact the heart during development, Professor Timothy C. Cox (from the University of Washington in Seattle) and colleagues used a heart-specific knockout approach in mice to inactivate a gene crucial for normal mitochondrial function. Their experimental methods established embryonic female mice with mosaic hearts composed of mixed cell populations: half normal and half "diseased" (lacking the gene). However, surprisingly, at birth the diseased cells represented only about 10% of the cardiac tissue.
"Our findings reveal an impressive regenerative capacity of the fetal heart that can compensate for an effective loss of half of the cardiac tissue," concludes Professor Cox. "To the best of our knowledge, this represents the first in vivo demonstration of selection against diseased tissue during embryonic heart development." The work also suggests that some cell populations within the heart are better able to regenerate than others and that those others are likely to be the source of later pathology.
Cell Press
Cardiac Tissue Current Events and Cardiac Tissue News RSSResearchers develop innovative imaging system to study sudden cardiac arrest
A research team at Vanderbilt University has developed an innovative optical system to simultaneously image electrical activity and metabolic properties in the same region of a heart, to study the complex mechanisms that lead to sudden cardiac arrest.
Bioengineers develop a microfabricated device to measure cellular forces during tissue development
A University of Pennsylvania-collaboration of bioengineers studying the physical forces generated by individual cells has created a tiny micron-sized device that allows researchers to measure and manipulate cellular forces as assemblies of living cells reorganize themselves into tissues.
Adult Bone Marrow Stem Cells Injected into Skeletal Muscle Can Repair Heart Tissue
University at Buffalo researchers have demonstrated for the first time that injecting adult bone marrow stem cells into skeletal muscle can repair cardiac tissue, reversing heart failure.
Women with chest pain less likely then men to get proper treatment from paramedics
Women with chest pain are less likely than male patients to receive recommended, proven therapies while en route to the hospital.
Mini heart attacks lessen damage from major ones
Researchers have discovered one potential mechanism by which briefly cutting off, then restoring, blood flow to arteries prior to a heart attack lessens the damage caused, according to a study published today in the journal Cardiovascular Research.
MIT: Mending broken hearts with tissue engineering
Broken hearts could one day be mended using a novel scaffold developed by MIT researchers and colleagues.
Stem cell regeneration repairs congenital heart defect
Mayo Clinic investigators have demonstrated that stem cells can be used to regenerate heart tissue to treat dilated cardiomyopathy, a congenital defect.
Advanced blood analysis may speed diagnosis of heart attacks
Someday doctors may be able to use a blood test to confirm within minutes, instead of hours, if a patient is having a heart attack, allowing more rapid treatment that could limit damage to heart muscle.
Saliva can help diagnose heart attack, study shows
Early diagnosis of a heart attack may now be possible using only a few drops of saliva and a new nano-bio-chip, a multi-institutional team led by researchers at The University of Texas at Austin reported at a recent meeting of the American Association for Dental Research.
Stem cells derived from adult testes produce wide range of tissue types
After a decade of research, Howard Hughes Medical Institute scientists have succeeded in reprogramming adult stem cells from the testes of male mice into functional blood vessels and contractile cardiac tissue.
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Cardiac Myocyte-Connective Tissue Interactions in Health and Disease (Issues in Biomedicine) by T. F. Robinson (Author), R. K. H. Kinne (Editor) | |
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Cardiac Muscle Tissue Pseudocolored Micrograph Photographic Poster Print, 40x30 by Art.com Art.com is the world's largest retailer of art prints, posters, photographs, and framed artwork. With our huge selection of over 400,000 prints, you'll easily find the perfect piece for your home, office, or classroom. Our art is printed on quality paper. When you order framed artwork, the piece is built by our team of in-house professionals. Visit our Amazon store today at www.amazon.com/artdotcom to find Special Offers and search for products based on 'Artist Name' and 'Subject Categories' such as Movie, Music, Vintage, TV, Children, Travel, Kitchen, Museum Art, Animals, Floral, Motivational, and Sports. Art.com is dedicated to providing you with high quality products and service by offering you 100% satisfaction guaranteed. We ship internationally to over 80 countries. Decorate your... |
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Hawthorn extract 500mg 120C by PEN Hawthorn extract provides nutritional support for healthy cardiovascular function. This herbal formula improves coronary flow, preserves and protects heart tissue, and increases the strength of myocardial contractions. Hawthorn offers a natural way to enhance and strengthen cardiovascular health. |
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Cardiac Tissue Engineering (Synthesis Lectures on Tissue Engineering) by Smadar Cohen (Author), Sigalit Amitay-shafrut (Author), K. A. Athanasiou (Editor) | |
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Embryonic stem cells transformed into insulin-producing cells and cardiac tissue, Israeli researchers report.: An article from: Transplant News by Transplant Communications, Inc. (Publisher) This digital document is an article from Transplant News, published by Transplant Communications, Inc. on August 17, 2001. The length of the article is 692 words. The page length shown above is based on a typical 300-word page. The article is delivered in HTML format and is available in your Amazon.com Digital Locker immediately after purchase. You can view it with any web browser. Citation Details Title: Embryonic stem cells transformed into insulin-producing cells and cardiac tissue, Israeli researchers report. Publication: Transplant News (Newsletter) Date: August 17, 2001 Publisher: Transplant Communications, Inc. Volume: 11 Issue: 15 Page: NA Distributed by Thomson... | |
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Cardiac Muscle Tissue Pseudocolored Micrograph Photographic Poster Print, 16x12 by Art.com Art.com is the world's largest retailer of art prints, posters, photographs, and framed artwork. With our huge selection of over 400,000 prints, you'll easily find the perfect piece for your home, office, or classroom. Our art is printed on quality paper. When you order framed artwork, the piece is built by our team of in-house professionals. Visit our Amazon store today at www.amazon.com/artdotcom to find Special Offers and search for products based on 'Artist Name' and 'Subject Categories' such as Movie, Music, Vintage, TV, Children, Travel, Kitchen, Museum Art, Animals, Floral, Motivational, and Sports. Art.com is dedicated to providing you with high quality products and service by offering you 100% satisfaction guaranteed. We ship internationally to over 80 countries. Decorate your... |
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CRITICAL CARE CLINICS VOLUME 12 NUMBER 4 OCTOBER 1996: Monitoring Cardiac Function and Tissue Perfusion by W. B. Saunders (Publisher) | |
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Cardiac Muscle Tissue Pseudocolored Micrograph Photographic Poster Print, 32x24 by Art.com Art.com is the world's largest retailer of art prints, posters, photographs, and framed artwork. With our huge selection of over 400,000 prints, you'll easily find the perfect piece for your home, office, or classroom. Our art is printed on quality paper. When you order framed artwork, the piece is built by our team of in-house professionals. Visit our Amazon store today at www.amazon.com/artdotcom to find Special Offers and search for products based on 'Artist Name' and 'Subject Categories' such as Movie, Music, Vintage, TV, Children, Travel, Kitchen, Museum Art, Animals, Floral, Motivational, and Sports. Art.com is dedicated to providing you with high quality products and service by offering you 100% satisfaction guaranteed. We ship internationally to over 80 countries. Decorate your... |
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Cardiac Reconstructions with Allograft Tissues by Richard A. Hopkins (Author), T. Xenakis (Illustrator), V.J. Ferrans (Illustrator), S.L. Hilbert (Illustrator), M. Jones (Illustrator), P.L. Lange (Illustrator), L.Jr. Wolfinbarger (Illustrator), K.E. Karlson (Illustrator), G.A. Karlson (Illustrator) Cryopreserved allograft tissues are now standard materials for the reconstructive cardiac surgeon. Since publication of the first edition of Cardiac Reconstructions with Allograft Valves in 1989, the field has progressed dramatically with increased clinical use of cardiovascular allograft tissues, with the development of new surgical techniques, and with advances in the understanding of the fundamentals of valve transplantation biology and cryopreservation. As a result, over two-thirds of the present volumes represents new material. Fifty-six authors bring their expertise to thirteen comprehensive, lavishly illustrated sections which discuss the principles of the use of homograft valves, major clinical series of homograft valves for both left and right ventricular outflow tracts,... |
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New Concepts in Blood Formation and Cell Generation in Malignant and Benign Tissues : Volume 2 : Cardiac Muscle by Hemprova Ghosh McDonald (Author) |
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