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Biomarkers for identifying infant infections
October 15, 2008Infection is the leading cause of infant deaths worldwide, and particularly a common killer of weaker, pre-term infants. Current diagnostic tests can be slow and non-specific, but researchers have now identified potential biomarkers in the blood that can rapidly identify both the onset of infection and type of microbe.
The circulatory system is a major hotbed of immune system activity, so Stephen Kingsmore and colleagues analyzed plasma samples from 107 infected and non-infected premature infants to try and identify proteins that could reliably identify an infected state.
Their analysis revealed eight proteins, associated with immune responses like inflammation and blood coagulation, which were consistently over-expressed in infected neonates. In addition, the relative levels of these serum proteins could provide insight into the type of infection (for example, the inflammatory proteins IL-6 and IL-8 were 1000-fold higher in streptococcus infections compared to other types).
Kingsmore and colleagues do note that these biomarkers are not completely accurate and thus not ready for any routine use, but with additional studies using larger numbers on infants and different types of analysis (some of which are already underway), a reliable set of infection biomarkers may soon become available.
American Society for Biochemistry and Molecular Biology
Kingsmore and colleagues do note that these biomarkers are not completely accurate and thus not ready for any routine use, but with additional studies using larger numbers on infants and different types of analysis (some of which are already underway), a reliable set of infection biomarkers may soon become available.
American Society for Biochemistry and Molecular Biology
Maternal HIV-1 treatment protects against transmission to newborns
Mothers receiving highly active antiretroviral therapy (HAART) to treat HIV-1 infection are less likely than untreated mothers to transmit the virus to their newborns through breastfeeding.
AIDS drugs have saved 3 million years of life in the US
Increasingly effective HIV therapy—including a decade of highly active antiretroviral therapy (HAART)—has provided 3 million years of extended life to Americans with AIDS since 1989, report researchers funded by the National Institute of Allergy and Infectious Diseases (NIAID), part of the National Institutes of Health (NIH).
Breastfeeding does not protect against asthma and allergic diseases (pp 887, 901)
A longitudinal study in this week's issue of THE LANCET provides compelling evidence that breastfeeding does not protect against asthma and atopy in childhood and early adulthood-authors of the study suggest that breastfeeding may actually increase the risk of these diseases. Breastfeeding is widely advocated to reduce the risk of atopy and asthma, but the evidence for this effect is conflicting. Malcolm Sears and colleagues from McMaster University, Canada, and the University of Otago, New Zealand, assessed the long-term outcomes of asthma and atopy related to breastfeeding in a New Zealand population. Around 1000 children from Dunedin, New Zealand, who were born between 1972 and early 197
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Ambu Disposable Face Masks, Infant by Ambu Inc Features of the Ambu Disposable Face Masks: Ambu Disposable Face Masks are designed for use with manual and automatic resuscitators and ventilators. Crystal clear dome for easy observation of the patient's condition. Dome with thumb rest and soft, shaped, airfilled cuff allows a tight fit to the patient's face with an easy grip. Disposable/single patient use - The combination of lower cost disposable materials and the single patient use concept, offers minimized risk of cross infection without need for establishing and maintaining resource consuming cleaning, disinfecting and sterilizing procedure. Mask dome and cushion are made of PVC. Non-sterile. The product referenced on this detail page is sold be Each. |
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Nap Nanny Infant Sleep Aide, Sage by Nap Nanny |
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