 |
|
Biomarkers for identifying infant infections
October 15, 2008Infection is the leading cause of infant deaths worldwide, and particularly a common killer of weaker, pre-term infants. Current diagnostic tests can be slow and non-specific, but researchers have now identified potential biomarkers in the blood that can rapidly identify both the onset of infection and type of microbe.
The circulatory system is a major hotbed of immune system activity, so Stephen Kingsmore and colleagues analyzed plasma samples from 107 infected and non-infected premature infants to try and identify proteins that could reliably identify an infected state.
Their analysis revealed eight proteins, associated with immune responses like inflammation and blood coagulation, which were consistently over-expressed in infected neonates. In addition, the relative levels of these serum proteins could provide insight into the type of infection (for example, the inflammatory proteins IL-6 and IL-8 were 1000-fold higher in streptococcus infections compared to other types).
Kingsmore and colleagues do note that these biomarkers are not completely accurate and thus not ready for any routine use, but with additional studies using larger numbers on infants and different types of analysis (some of which are already underway), a reliable set of infection biomarkers may soon become available.
American Society for Biochemistry and Molecular Biology
Kingsmore and colleagues do note that these biomarkers are not completely accurate and thus not ready for any routine use, but with additional studies using larger numbers on infants and different types of analysis (some of which are already underway), a reliable set of infection biomarkers may soon become available.
American Society for Biochemistry and Molecular Biology
AIDS drugs have saved 3 million years of life in the US
Increasingly effective HIV therapy—including a decade of highly active antiretroviral therapy (HAART)—has provided 3 million years of extended life to Americans with AIDS since 1989, report researchers funded by the National Institute of Allergy and Infectious Diseases (NIAID), part of the National Institutes of Health (NIH).
Breastfeeding does not protect against asthma and allergic diseases (pp 887, 901)
A longitudinal study in this week's issue of THE LANCET provides compelling evidence that breastfeeding does not protect against asthma and atopy in childhood and early adulthood-authors of the study suggest that breastfeeding may actually increase the risk of these diseases. Breastfeeding is widely advocated to reduce the risk of atopy and asthma, but the evidence for this effect is conflicting. Malcolm Sears and colleagues from McMaster University, Canada, and the University of Otago, New Zealand, assessed the long-term outcomes of asthma and atopy related to breastfeeding in a New Zealand population. Around 1000 children from Dunedin, New Zealand, who were born between 1972 and early 197
More Infant Infections Current Events and Infant Infections News Articles
 | Infection in the Neonate: A Comprehensive Guide to Assessment, Management and Nursing Care (Askin, Infection in the Neonate) by Debbie F., Ed. Askin |
 | Clinical Management of Infections in Immunocompromised Infants and Children This volume is the ideal reference for house staff dealing with immunocompromised infants and children. A major section provides comprehensive coverage of infections associated with specific immunodeficient entities, such as AIDS, leukemia/lymphoma, and transplantations. Another section focuses on infections at specific anatomic locations. Chapters in these sections discuss pathophysiology,... |
| Invasive Group B streptococcal infections in infants, France.(DISPATCHES): An article from: Emerging Infectious Diseases by Claire Poyart, Helene Reglier-Poupet, Asmaa Tazi, Annick Billoet, Nicolas Dmytruk, Philippe Bidet, Edouard Bingen, Josette Raymond, Patrick Trieu-Cuot This digital document is an article from Emerging Infectious Diseases, published by U.S. National Center for Infectious Diseases on October 1, 2008. The length of the article is 2289 words. The page length shown above is based on a typical 300-word page. The article is delivered in HTML format and is available immediately after purchase. You can view it with any web browser.Citation DetailsTitle:... | |
| Four factors rule out serious bacterial infections. (Febrile Infants Under 3 Months).: An article from: Pediatric News by Timothy F. Kirn This digital document is an article from Pediatric News, published by International Medical News Group on March 1, 2002. The length of the article is 412 words. The page length shown above is based on a typical 300-word page. The article is delivered in HTML format and is available in your Amazon.com Digital Locker immediately after purchase. You can view it with any web browser.Citation... | |
| Invasive Group B streptococcal infection in infants, Malawi.(RESEARCH): An article from: Emerging Infectious Diseases by Katherine J. Gray, Sally L. Bennett, Neil French, Amos J. Phiri, Stephen M. Graham This digital document is an article from Emerging Infectious Diseases, published by Thomson Gale on February 1, 2007. The length of the article is 5855 words. The page length shown above is based on a typical 300-word page. The article is delivered in HTML format and is available in your Amazon.com Digital Locker immediately after purchase. You can view it with any web browser.Citation... | |
| Peak pattern in infants' MRSA infections may reflect sources, a retrospective study finds.(Clinical Rounds): An article from: Skin & Allergy News by Michele G. Sullivan This digital document is an article from Skin & Allergy News, published by Thomson Gale on June 1, 2007. The length of the article is 551 words. The page length shown above is based on a typical 300-word page. The article is delivered in HTML format and is available in your Amazon.com Digital Locker immediately after purchase. You can view it with any web browser.Citation DetailsTitle: Peak... | |
| Infections in Immunocompromised Infants and Children University of Tennessee, Memphis. Text for physicians on the pathogenesis, clinical manifestations, diagnosis, and treatment of infectious disease in immunocompromised children. Topics include immunocompromised neonates, transplants, AIDS. 71 Contributors, mostly... | |
| Breast-feeding may decrease risk of infant death; reduced risk of infection, SIDS, injuries.(Women's Health): An article from: Family Practice News by Michele G. Sullivan This digital document is an article from Family Practice News, published by International Medical News Group on July 1, 2004. The length of the article is 979 words. The page length shown above is based on a typical 300-word page. The article is delivered in HTML format and is available in your Amazon.com Digital Locker immediately after purchase. You can view it with any web browser.Citation... | |
| Prevention and Treatment of HIV Infection in Infants and Children (Annals of the New York Academy of Sciences) Perinatal use of Zidovudine, AZT and other treatments have reduced the rate of HIV-infected infants to an average 300 per year in developed nations; in emerging nations, 1800 infants are born at risk of HIV every day. A future generation on HIV infections can be prevented by delivering known interventions at more culture-specific levels. This volume combines the proceedings of the two conferences... | |
| Infant prematurity heightens skin infection risk.(Infectious Diseases): An article from: Skin & Allergy News by Betsy Bates |
| © 2009 BrightSurf.com |