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New research could save lives and millions of dollars
October 23, 2008
The Hunter Medical Research Institute (HMRI) Stroke Research Group has developed a system to fast track stroke treatment which could benefit thousands of Australian stroke patients and save millions of dollars annually. The system (called the Pre-hospital Acute Stroke Triage or PAST Protocol) reduces pre-hospital and emergency department delays to allow more stroke patients to receive brain saving thrombolysis or clot busting treatment within the three hour treatment window.
Results of the Australian-first trial conducted at John Hunter Hospital, New South Wales, are published in the latest Medical Journal of Australia.
"By reversing the crippling effects of stroke we are enabling more people to return to their families, their homes and their jobs. This also reduces the demand on nursing home beds, in-hospital rehabilitation programs and the health care dollar," said lead investigator Debbie Quain, a member of the HMRI Stroke Research Group and a Hunter New England Health Stroke Research Nurse.
As a result of the protocol, the number of patients treated with thrombolytic therapy at John Hunter Hospital rose from 4.7 per cent to 21.4 per cent. Of those treated, 43 per cent had minimal or no disability three months after the stroke.
Currently, less than 1 per cent of patients who have experienced an ischaemic stroke receive thrombolysis treatment in Australia. The world best practise rate is 15 to 20 per cent.
"If the PAST protocol is implemented nationally, an additional 2,500 patients could receive thrombolysis treatment each year and an estimated cost saving of $31.2 million dollars per annum will be realised," said Associate Professor Chris Levi, Head of the HMRI Stroke Research Group and Director of Acute Stroke Services at John Hunter Hospital.
The protocol equips ambulance officers with a stroke assessment tool to more accurately identify patients who may benefit from clot busting treatment, gives the ambulance control officer phone contact with a stroke neurologist to identify 'out of area' patients who may be eligible for treatment, and allows an on-call acute stroke team to respond and provide immediate care for the patient on arrival at hospital.
Stroke affects 53,000 people in Australia each year.
Research Australia
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Vascular Interventional Radiology: Angioplasty, Stenting, Thrombolysis and Thrombectomy (Medical Radiology / Diagnostic Imaging)
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This volume focuses on the current evidence surrounding the use of endovascular therapy. It updates and complements the earlier "Medical Radiology" volume on the Radiology of Peripheral Vascular Diseases. Some background information is provided on vascular biology and the facilities required for safe endovascular practice, along with guidance on consent issues. Further chapters deal with endovascular treatment in particular arterial territories, and include the evidence in favour of or against the use of specific treatments. The most up-to-date evidence surrounding endovascular aneurysm repair is discussed. There are also chapters on venous interventions, including the endovascular management of varicose veins. This book will be of value both to interventional radiologists and to vascular...
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Coronary Thrombolysis a Research Compend
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As the number of patients with thrombosis and thrombolysis increases, there is a critical need for clinicians to learn the latest scientific discoveries and treatment options. This timely Third Edition is a comprehensive text for cardiologists, hematologists, and pharmacologists in need of a resource on current agent development technology for treating cardiovascular and thromboembolic diseases.
New to the Third Edition:
a thorough examination of all the agents involved in treating thrombosis chapters on biomarkers, testing, and pharmacogenomics key topics, including new targets for antithrombotics, the development of novel classes of platelet inhibitors, new thrombolytic therapies, and evolving clinical uses of thrombolytics for ischemic stroke...
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This reference book offers in-depth coverage of pharmacological and mechanical interventions available for the treatment of acute myocardial infarction. It examines the efficacy of thrombolytic therapy by analyzing infarct artery patency, left ventricular function, mortality and complications.;The book presents therapeutic results on the use of nitrates, beta adrenergic blockers and calcium channel blockers, details antiplatelet and anticoagulant therapy, describes new antiplatelet and antithrombin agents, investigates combination thrombolytic therapy and the potential of angiotensin-converting enzyme inhibitors.
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Citation Details Title: MRI buys time for thrombolysis of acute stroke.(Clinical Rounds)(magnetic resonance imaging ) Author: Mitchel L. Zoler Publication: Family Practice News (Magazine/Journal) Date: June 15, 2005 Publisher: International Medical News Group Volume: 35 Issue: 12 Page: 58(1)
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Citation Details Title: MRI opens thrombolysis window after stroke.(Neuropsychiatric Medicine) Author: Mitchel L. Zoler Publication: Clinical Psychiatry News (Magazine/Journal) Date: June 1, 2005 Publisher: International Medical News Group Volume: 33 Issue: 6 Page: 59(1)
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Citation Details Title: Desmoteplase could extend thrombolysis treatment window.(Clinical Rounds) Author: Kerri Wachter Publication: Family Practice News (Magazine/Journal) Date: June 15, 2005 Publisher: International Medical News Group Volume: 35 Issue: 12 Page: 58(1)
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