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What is the function of NOD2 in colonic epithelial cells?
October 23, 2008NOD2 is a cytosolic pattern recognition receptor similar in structure and function to Toll like receptors (TLRs). It can recognize and respond to a component found in the cell wall of bacteria, muramyl dipeptide (MDP), and has been shown to play an important role in the innate immune response of macrophages to bacterial infections. However, the function of NOD2 in the gastrointestinal tract and the colon and its contribution of mutant NOD2 alleles to the pathogenesis of CD is still unclear.
A research article to be published on October 14, 2008 in the World Journal of Gastroenterology addresses this question. The research team led by Professor Simon Carding from the University of Leeds used in vivo and in vitro studies to analyse the specific function of NOD2 in colonic epithelial cells.
These results highlight for the first time the importance of NOD2 in the regulation of epithelial cell growth and survival and consequently the integrity of the intestinal epithelial cell barrier, that is required for protection against pathogenic and opportunistic bacterial infections. further investigation is needed to assess if these receptors work alongside each other in the regulation of epithelial cell homeostasis.
World Journal of Gastroenterology
Epithelial Cells Current Events and Epithelial Cells News RSSScientists discover influenza's Achilles heel: Antioxidants
As the nation copes with a shortage of vaccines for H1N1 influenza, a team of Alabama researchers have raised hopes that they have found an Achilles' heel for all strains of the flu-antioxidants.
Skin cells may provide early warning for cancer risk elsewhere in body
While some scientists have argued that cancer is such a complex genetic disease that you'd have to sequence a person's complete genome in order to predict his or her cancer risk, a University of California, Berkeley, cell biologist suggests that the risk may be more simply determined by inexpensively culturing a few skin cells.
UNC study pinpoints gene controlling number of brain cells
In populating the growing brain, neural stem cells must strike a delicate balance between two key processes - proliferation, in which the cells multiply to provide plenty of starting materials - and differentiation, in which those materials evolve into functioning neurons.
The vasculature emerges as a potential therapeutic target in treating ADPKD liver cysts
As part of an effort to develop effective medical therapies that block the progression of liver cyst growth in patients with Autosomal Dominant Polycystic Kidney Disease (ADPKD), researchers at the University of Colorado Anschutz Medical Center have found that the liver cyst walls develop and maintain a vasculature as they grow out from the body of the liver and that factors released by epithelial cells that line the liver cyst wall lumen can drive the proliferation and development of vascular endothelial cells.
Weill Cornell Researchers Discover New Anti-Tuberculosis (TB) Compounds
Attempts to eradicate tuberculosis (TB) are stymied by the fact that the disease-causing bacteria have a sophisticated mechanism for surviving dormant in infected cells.
Lung cancer suppresses miR-200 to invade and spread
Primary lung cancer shifts to metastatic disease by suppressing a family of small molecules that normally locks the tumor in a noninvasive state, researchers at The University of Texas M. D. Anderson Cancer Center report in the Sept. 15 edition of Genes and Development.
Study shows how disruption of spectrin-actin network causes lens cells in the eye to lose shape
A network of proteins underlying the plasma membrane keeps epithelial cells in shape and maintains their orderly hexagonal packing in the mouse lens, say Nowak et al.
Overexpressed protein converts noninvasive breast cancer into invasive disease
Active, but non-invasive breast cancer is set free to roam as invasive breast cancer when an overexpressed protein converts it to a different cell type, scientists at The University of Texas M. D. Anderson Cancer Center report in the Sept. 9 issue of the journal Cancer Cell.
Discovery may lead to powerful new therapy for asthma
University of Texas Medical Branch at Galveston researchers have found that a single enzyme is apparently critical to most allergen-provoked asthma attacks - and that activity of the enzyme, known as aldose reductase, can be significantly reduced by compounds that have already undergone clinical trials as treatments for complications of diabetes.
UF scientists program blood stem cells to become vision cells
University of Florida researchers were able to program bone marrow stem cells to repair damaged retinas in mice, suggesting a potential treatment for one of the most common causes of vision loss in older people.
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Epithelial Cell Culture (Handbooks in Practical Animal Cell Biology) by Ann Harris (Editor) Epithelial Cell Culture contains chapters by experts on epithelial cells derived from the airway, intestine, pancreas, kidney and bladder, genital ducts, mammary glands, skin glands and appendages, and keratinocytes. |
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Epithelial Cell Culture Protocols (Methods in Molecular Biology) by Clare Wise (Editor) National Institute for Medical Research, London, UK. Covers a wide variety of protocols, aimed at researchers and clinicians. Includes a guide to basic and sophisticated techniques in epithelial cell culture and reproducible methods for the establishment and maintenance of primary cultures. |
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Pap Smear Squamous Cells Intra-Epithelial Lesion Photographic Poster Print, 32x24 by AllPosters.com AllPosters.com is the world's #1 seller of posters, prints, photographs, specialty products and framed art. We're dedicated to bringing our customers the best selection of high quality wall décor that is perfect for their home or office. Browse our catalog of over 300,000 items that include entertainment and specialty posters, decorative prints, and art reproductions. Whether you're looking for your favorite movie or music poster, a framed Monet reproduction, or a print of the Eiffel Tower you will find it at AllPosters.com. Visit our Amazon store today at www.amazon.com/allposters to find Special Offers and search by subject category or artist. AllPosters.com provides unmatched service with a 100% satisfaction guarantee. We ship internationally to over 80 countries. Decorate your... |
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The Aging Eye: New Therapies for Age Related Macular Degeneration In the past two years, there have been rapid and dramatic improvements in the treatment of macular degeneration which is the leading cause of blindness in the United States in persons over age 65. In this lecture, Mark Blumenkranz, MD covers new advances in this disease that have changed our understanding and approach to it. Mark S. Blumenkranz, MD, is Professor and Chairman of the Department of Ophthalmology at Stanford University. He is the author of more than 100 peer-reviewed publications and book chapters in the area of vitreoretinal surgery, with special interests in surgical adjuvant pharmacology and new microsurgical and laser techniques. Dr. Blumenkranz was instrumental in developing the successful laser vision correction program at Stanford and serves as a principal... |
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Epithelial Morphogenesis in Development and Disease (Cell Adhesion and Communication) by Walter Birchmeier (Author), Carmen Birchmeier (Author) Bringing together a series of articles on the structural, functional, and developmental characteristics of epithelia, this volume represents a timely and valuable contribution to a growing field of study. Divided into three sections, the first part highlights the typical features of epithelia that can be understood in molecular terms: adhesive properties, interactions with neighboring cells and with the extracellular matrix, epithelial transport, and epithelial-specific gene regulation. The first cell types that emerge during development already show epithelial characteristics. The second section describes the generation and morphogenesis of the first epithelia, molecular control of epithelial-mesenchymal conversions (mesoderm formation) as well as molecular characteristics of... |
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Microbial Pathogenesis and the Intestinal Epithelial Cell b |
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Pap Smear Squamous Cells Intra-Epithelial Lesion Photographic Poster Print, 40x30 by Art.com Art.com is the world's largest retailer of art prints, posters, photographs, and framed artwork. With our huge selection of over 400,000 prints, you'll easily find the perfect piece for your home, office, or classroom. Our art is printed on quality paper. When you order framed artwork, the piece is built by our team of in-house professionals. Visit our Amazon store today at www.amazon.com/artdotcom to find Special Offers and search for products based on 'Artist Name' and 'Subject Categories' such as Movie, Music, Vintage, TV, Children, Travel, Kitchen, Museum Art, Animals, Floral, Motivational, and Sports. Art.com is dedicated to providing you with high quality products and service by offering you 100% satisfaction guaranteed. We ship internationally to over 80 countries. Decorate your... |
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Culture of Epithelial Cells by R. Ian Freshney (Editor), Mary G. Freshney (Editor) "…a wonderful compendium of current in vitro approaches that will be a useful resource to those just starting to work with an epithelial cell system as well as those that have been working with them for years and years." —Pharmaceutical Research This completely revised and expanded new edition provides detailed descriptions of fundamental and practical aspects relating to the in vitro cultivation of disparate types of epithelia. In recent years, the use of epithelial cell culture in cell biology and tissue engineering has increased dramatically. This revision reflects those advances by including new chapters on the culture of animal and human hepatocytes, kidney epithelium, and bladder epithelium. Each chapter provides an introductory review of the principles... |
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Candida Adherence to Epithelial Cells by Mahmoud A. Ghannoum (Author), Samir S. Radwan (Author) This is the first book ever to be published on this topic! Comprehensively packed with up-to-date research information, this volume is written with both the beginner and the established research expert in mind. Complemented with tables, line drawings, and photographs, this resource provides background material which allows the reader to become familiar with Candida albicans and its relation to its host. This unique work places particular emphasis on the effect of therapeutic agents on adherence and adherence blockage in the control of Candidosis. The goal of these studies is to be of practical value in the control and prevention of Candida infections. This book is of specific interest to all who are involved (at any level) with microbiology, infectious diseases, medical and veterinary... |
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Pap Smear Squamous Cells Intra-Epithelial Lesion Photographic Poster Print, 16x12 by AllPosters.com AllPosters.com is the world's #1 seller of posters, prints, photographs, specialty products and framed art. We're dedicated to bringing our customers the best selection of high quality wall décor that is perfect for their home or office. Browse our catalog of over 300,000 items that include entertainment and specialty posters, decorative prints, and art reproductions. Whether you're looking for your favorite movie or music poster, a framed Monet reproduction, or a print of the Eiffel Tower you will find it at AllPosters.com. Visit our Amazon store today at www.amazon.com/allposters to find Special Offers and search by subject category or artist. AllPosters.com provides unmatched service with a 100% satisfaction guarantee. We ship internationally to over 80 countries. Decorate your... |
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