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Are bone marrow mononuclear cells effective in reducing hepatic lesions?
October 24, 2008Liver fibrosis occurs in the setting of chronic injury caused by different etiologies constituting a serious worldwide public health problem. In addition to schistosomiasis, hepatopathies due to alcohol, viral hepatitis, drugs, metabolic and autoimmune diseases, and congenital abnormalities are important causes of liver fibrosis. New therapeutic strategies aiming to minimize damages caused by hepatic fibrogenesis in chronic liver diseases are of great interest.
Adult bone marrow contains pluripotent stem cells with the ability to differentiate into diverse cell types, including hepatocytes. The regenerative potential of bone marrow stem cells has been tested in experimental models of hepatic injury, demonstrating the ability of bone marrow cells (BMCs) to generate hepatocytes under tissue stress in mice and human.
A research team leaded by Milena Botelho Pereira Soares from Brazil investigated the potential of syngeneic bone marrow mononuclear cells in the modulation of fibrosis, albumin expression and cellular alterations. This will be published on October 14, 2008 in the World Journal of Gastroenterology
They found that Transplanted GFP+ cells migrated to granuloma areas and reduced the percentage of liver fibrosis. The presence of donor-derived cells was confirmed by Fluorescence in situ hybridization (FISH) analysis for detection of cells bearing Y chromosome and by PCR analysis for detection of GFP DNA. The levels of TGF-beta, a cytokine associated with fibrosis deposition, in liver fragments of mice submitted to therapy were reduced. The number of oval cells in liver sections of S.mansoni -infected mice increased 3-4 fold after transplantation. A partial recovery in albumin expression, which is decreased upon infection with S.mansoni, was found in livers of infected mice after cellular therapy.
They concluded that transplantation of BMCs in mice with chronic liver disease caused by S.mansoni infection decreased liver fibrosis and contributed to an increase in precursor cells as well as to the generation of new hepatocytes and/or to the improvement of the function of resident hepatocytes. Although there are still many unanswered questions regarding the mechanisms of action of transplanted cells in hepatic lesions, their results reinforce the use of cell-based therapies for patients with chronic liver diseases.
World Journal of Gastroenterology
They found that Transplanted GFP+ cells migrated to granuloma areas and reduced the percentage of liver fibrosis. The presence of donor-derived cells was confirmed by Fluorescence in situ hybridization (FISH) analysis for detection of cells bearing Y chromosome and by PCR analysis for detection of GFP DNA. The levels of TGF-beta, a cytokine associated with fibrosis deposition, in liver fragments of mice submitted to therapy were reduced. The number of oval cells in liver sections of S.mansoni -infected mice increased 3-4 fold after transplantation. A partial recovery in albumin expression, which is decreased upon infection with S.mansoni, was found in livers of infected mice after cellular therapy.
They concluded that transplantation of BMCs in mice with chronic liver disease caused by S.mansoni infection decreased liver fibrosis and contributed to an increase in precursor cells as well as to the generation of new hepatocytes and/or to the improvement of the function of resident hepatocytes. Although there are still many unanswered questions regarding the mechanisms of action of transplanted cells in hepatic lesions, their results reinforce the use of cell-based therapies for patients with chronic liver diseases.
World Journal of Gastroenterology
Liver Fibrosis Current Events and Liver Fibrosis News RSSAntifibrotic effects of green tea
Several studies have shown that lipid peroxidation stimulates collagen production in fibroblasts and hepatic stellate cells (HSC), and plays an important role in the development of liver fibrosis.
The use of stem cells in regenerative medicine may also be detrimental for health
The use of stem cells in regenerative medicine is not always beneficial for human health, it may even be harmful according to a work done by the University of Granada and University of León. Scientists have demonstrated that transplantation of human mononuclear cells isolated from umbilical cord blood exerted a deleterious effect in rats with liver cirrhosis.
UCSD researchers pave the way for effective liver treatments
A combination of bioengineering and medical research at the University of California, San Diego has led to a new discovery that could pave the way for more effective treatments for liver disease.
A potential therapeutic agent for hepatic fibrosis
Accumulating evidence suggests that connective tissue growth factor (CCN2) plays a central role in fibrotic conditions in many organ systems.
Mutations in gene linked to ciliopathies
An international team of scientists, led by researchers at the University of California, San Diego School of Medicine, have discovered a connection between mutations in the INPP5E gene and ciliopathies.
Probe position may change results in liver stiffness measurements in transient elastography
A major clinical challenge is to find the best method to evaluate and to manage the increasing numbers of patients with chronic liver disease. Liver biopsy, due to its risks and limitations, is no longer considered mandatory as the first-line indicator of liver injury, and several markers have been developed as non-invasive alternatives.
FibroTest attributes to generate decision trees in hepatitis C
In recent years the use of non-invasive biomarkers to assess liver fibrosis has become widely accepted.
p90RSK: A new therapeutic target for liver fibrosis?
Cirrhosis is a world wide, bad prognosis liver disease and characterized by excessive collagen deposition and liver function damage.
Is telmisartan effective in treating non-alcoholic steatohepatitis?
Non-alcoholic fatty liver disease (NAFLD) and non-alcoholic steatohepatitis (NASH) are well-recognized causes of progressive liver disease leading to cirrhosis and hepatocellular carcinoma.
Varicella zoster infection causes severe autoimmune hepatitis
Autoimmune hepatitis (AIH) is a chronic liver inflammation of unknown etiology that is characterized by the presence of circulatory autoantibodies and ongoing liver tissue damage.
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