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Epilepsy drug may help Alzheimer's patients
October 27, 2008A popular epilepsy drug may also be beneficial in patients with Alzheimer's disease (AD), according to a new study to be published on October 27 in the Journal of Experimental Medicine. The anti-seizure drug valproic acid improved memory and reduced brain lesions in mice with an AD-like disease.
The study, lead by Weihong Song at the University of British Columbia in Vancouver, Canada, showed that treating mice with valproic acid soon after the onset of disease shrank the brain plaques typical of AD and even prompted damaged nerves to start repairing themselves. Most importantly, the drug improved the animals' performance in a variety of memory-related tests.
The acid worked by blocking a cascade of enzymatic reactions that culminates in the accumulation of a protein called beta-amyloid, which builds up to toxic levels in AD. Valproic acid helped mice less as their disease progressed, suggesting that future clinical trials should focus on people with early signs of AD. Valproic acid has been given to people with AD in the past but memory improvement was never assessed in those studies.
Rockefeller University Press
Rockefeller University Press
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Embryonic stem (ES) cells, known for their capacity to proliferate indefinitely and differentiate into almost all types of cells including hepatocytes, have raised the hope of cellular replacement therapy for liver failure.
Universitat Autonoma de Barcelona researchers first to clone mice in Spain
Researchers at the Department of Cell Biology, Physiology and Immunology at Universitat Autònoma de Barcelona (UAB) are the first to have cloned mice in Spain. Cloe, Cleo and Clona are three female brown-coloured mice and were born respectively on 12 May, 3 June and 10 June.
Common epilepsy drug could prevent and treat Alzheimer's disease
The team led by UBC Psychiatry Prof. Weihong Song, who is also the Jack Brown and Family Professor and Chair in Alzheimer's Disease at UBC, found that if Valproic Acid (VPA) is used as a treatment in early stages of AD memory deficit is reversed.
Chemical signature of manic depression discovered by scientists
People with manic depression have a distinct chemical signature in their brains, according to a new study. The research, published today in the journal Molecular Psychiatry, may also indicate how the mood stabilisers used to treat the disorder counteract the changes in the brain that it appears to cause.
Existing drugs show promise for treating end-stage renal disease in lupus
Studies in mice suggest that two drugs already approved by the U.S. Food and Drug Administration show promise for treating the complications of lupus.
Migraine treatment and prevention in women
Migraines are more common in the United States than diabetes, osteoarthritis or asthma. Of the 28 million people who experience migraines in this country, 18 million are women.
Boosting key protein in brain could improve seizure treatment, Stanford study finds
A naturally occurring protein in our brains could be the basis for a more promising epilepsy treatment-without the nasty side effects caused by many of the current medications.
Common anti-convulsant drug may help slow the progression of dementia
Researchers have found that a common anticonvulsant drug improved cognitive function and appeared to restore nerve cells in the brains of patients with HIV-related dementia.
UNC launches study of liver injury caused by drugs
The University of North Carolina at Chapel Hill is one of five clinical centers nationwide to receive funds from the National Institutes of Health to study why good medications are sometimes bad for the liver.
Antiepileptic Drug Developed At Hebrew University To Undergo Phase Three Clinical Trials Under New Agreement
The new antiepileptic drug valrocemide, developed at the Hebrew University of Jerusalem by Meir Bialer, the David Eisenberg Professor of Pharmacy, will undergo phase three clinical trials in the U.S. under a new agreement between Teva Pharmaceutical Industries of Israel and Acorda Therapeutics of the U.S. Teva acquired the rights to the drug from the Hebrew University's Yissum Research Development Company for the production of a treatment for epilepsy and other neurological and psychiatric diseases. Epilepsy is a widespread neurological disease. Approximately one percent of the world's population suffers from it, and annual sales of antiepileptic drugs in the U.S. amount to more than $2 bi
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Olympus America Valproic Acid Calibrator Ea - Model 4g109 by Olympus America Olympus America Valproic Acid Calibrator Ea - Model 4G109 : This product is being shipped directly to you from the manufacturer, and as such, may incur seperate delivery fees, plus freight charges. Please allow 4-6 weeks for delivery. SPECIAL NOTE: All s |
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