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A new Eph receptor tyrosine kinase overexpressed in gastric cancer was found
October 29, 2008The potential role of Eph receptor and ephrin ligand family in human cancer is receiving increasing attention. Compared with other Eph receptors, EphA4 is distinguished by its ability to bind to both type A ephrins and most type B ephrins. EphA4 reportedly forms a hetero receptor complex with FGFR1 and that EphA4/FGFR1 complex potentiates FGFR-mediated downstream signal transduction. However, alterations of EphA4 are not well understood in gastric cancer.
A research article to be published on October 7, 2008 in the World Journal of Gastroenterology will adress this question. This study was conducted by a team led by Dr. Hiroyuki Yamamoto of Sapporo Medical University in which they systematically analyzed expression of EphA4, FGFR1, and ephrins in gastric cancer.
Using reverse transcription-PCR (RT-PCR), real-time RT-PCR, immunohistochemistry, and cell growth assays, the research team analyzed the expression and role of EphA4 in gastric cancer, in relation to clinicopathological characteristics and the expression of FGFR1 and ephrin ligands. EphA4 overexpression at protein level was found and significantly associated with depth of invasion, recurrence, poor prognosis, and FGFR1 overexpression. The mRNAs for ephrin ligands were coexpressed in various combinations in gastric cancer cell lines and cancer tissues. Downregulation of EphA4 expression by siRNA resulted in a significant decrease in cancer cell growth in vitro.
In the view of the team, EphA4 is the first Eph/ephrin family member of which prognostic significance was shown in gastric cancer. EphA4 reportedly forms a hetero receptor complex with FGFR1 and that the EphA4/FGFR1 complex potentiates FGFR-mediated downstream signal transduction. FGFR1 expression was correlated with EphA4 expression. Therefore, EphA4 may play a role in gastric cancer, at least in part, through the interaction with FGFR signaling.
World Journal of Gastroenterology
In the view of the team, EphA4 is the first Eph/ephrin family member of which prognostic significance was shown in gastric cancer. EphA4 reportedly forms a hetero receptor complex with FGFR1 and that the EphA4/FGFR1 complex potentiates FGFR-mediated downstream signal transduction. FGFR1 expression was correlated with EphA4 expression. Therefore, EphA4 may play a role in gastric cancer, at least in part, through the interaction with FGFR signaling.
World Journal of Gastroenterology
Gastric Cancer Current Events and Gastric Cancer News RSSIs short-term Celecoxib intervention a effective method for preventing gastric carcinogenesis?
Since the isolation and culture of Helicobacter pylori (H. pylori) in 1983, this bacterium has become accepted as an important human pathogen for the development of gastritis, peptic ulcer, and gastric cancer.
A new explanation of 'Asian paradox'
Although Helicobacter pylori (H. pylori) has been classified as a class I (or definite) carcinogen by World Health Organization (WHO), the controversy as to why only a minority of infected patients develop gastric cancer still remains.
Will genomics help prevent the next pandemic?
This week, the Public Library of Science, an open-access publisher, presents the "Genomics of Emerging Infectious Disease," a collection of essays, perspectives, and reviews that explores how genomics-with all its associated tools and techniques-can provide insights into our understanding of emerging infectious disease.
Protein interaction network can respond Helicobacter pylori infection?
Helicobacter pylori (H pylori) is a gram negative bacterium which infects about 50% of the world population. H pylori colonization causes a strong systemic immune response.
A case of post-gastrectomy acute pancreatitis
Gastrectomy is commonly performed for both benign and malignant lesions. Although the incidence of post-gastrectomy acute pancreatitis (PGAP) is low compared to other well-recognized post-operative complications, it has been reported to be associated with a high mortality rate.
Does Helicobacter pylori eradication therapy prevent gastric cancer?
Although it has been demonstrated that Helicobacter pylori causes gastric cancer, it is still controversial that whether H. pylori eradication therapy is effective in primary prevention of gastric cancer.
New blood tests promise simple, cost-effective diagnosis of gastrointestinal cancers
Promising results from two new blood tests that can aid in the early identification of patients with gastrointestinal (GI) cancers will be presented at Europe's largest cancer congress.
NIH study reveals new genetic culprit in deadly skin cancer
Drawing on the power of DNA sequencing, National Institutes of Health researchers have identified a new group of genetic mutations involved in the deadliest form of skin cancer, melanoma.
PPAR-g agonists have potential therapeutic role in gastric carcinoma?
Recently, the potential of PPAR-γ as a target for the prevention and treatment of cancer has been widely studied.
D2 lymphadenectomy improves the long-term survival for patients with node-negative gastric cancer
Many studies favor an extended lymphadenectomy at the time of a potentially curative gastrectomy for node-positive gastric cancer, and the risk of long-term death tends to decrease when the number of resected lymph nodes increases to about 25.
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100 Q&A About Gastric Cancer (100 Questions & Answers about . . .) (100 Questions and Answers) by Manish A. Shah (Author) About 21,700 Americans are diagnosed with stomach cancer each year and it occurs most often in people in their 60s and 70s. Whether you're a newly diagnosed patient with gastric cancer or a friend or relative of someone with cancer, this book offers help. This book is an invaluable resource for anyone coping with the physical and emotional turmoil of this disease. The author Dr. Shah is from Memorial Sloan-Kettering Cancer Center, one of the few National Cancer Institute-designated cancer centers with a specific program in treating cancers of the upper gastrointestinal tract and has made many of the major advances in the treatment of these diseases. |
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Gastric Cancer by T. Sugimura (Editor), M. Sasako (Editor) The editors have produced a concise and up-to-date account of all aspects of gastric cancer, which is still one of the five major causes of cancer death in most countries of the world today. The book ranges from epidemiology, aetiology, and biology, to surgical and non-surgical treatements and primary and secondary prevention. It summarizes the latest progress in the various fields, as well as providing practical guidance on diagnosis and management, and is written by acknowledged experts in the subject both in the West and Japan. |
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Cure Gastric (Stomach) Cancer Long Sleeve T-shirt Large White by Shop Zeus |
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Gastric Cancer Awareness Ribbon Mouse Pad by MyHeritageWear.com The Gastric Cancer Ribbon proudly displayed on a mouse pad. There is no better way to achieve awareness for the meaning of the Gastric Cancer Ribbon than to display it on your mouse pad for everyone to see. The mouse pad measures at 9.25 x 7.75, it is machine washable, and the colors will not fade or run. Start gaining awareness today by presenting your Gastric Cancer Ribbon mouse pad at work or at home. It is certain to keep your mouse rolling in style all while gaining support and awareness! |
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Beating Gastric (Stomach) Cancer Together Keychain by Design a Product LLC Text on keychain: Beating Gastric (Stomach) Cancer Together * Durable acrylic key chain is crystal-clear and double-sided so the artwork or message is seen twice. * Sturdy metal ring holds your keys securely. * Full color printed images or messages are included. * If you have new ideas or need help selecting text for your custom keychains please contact us. * Size: 2 1/8" x 3 1/2" (Approx. business card) |
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Cancer Of The Stomach, A Clinical Study Of 921 Operatively And Pathologically Demonstrated Cases: With A Chapter On The Surgical Treatment Of Gastric Cancer by Frank Smithies (Author), Albert John Ochsner (Contributor) This scarce antiquarian book is included in our special Legacy Reprint Series. In the interest of creating a more extensive selection of rare historical book reprints, we have chosen to reproduce this title even though it may possibly have occasional imperfections such as missing and blurred pages, missing text, poor pictures, markings, dark backgrounds and other reproduction issues beyond our control. Because this work is culturally important, we have made it available as a part of our commitment to protecting, preserving and promoting the world's literature. |
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Proteinex 18 Liquid Protein 16 oz Bottle, 1/Each Black Cherry by LLorens Pharmaceuticals Proteinex®-18 is liquid predigested protein that has been broken down to its amino acid portions to provide patients with the highest concentration of protein in a small dose. Proteinex 18 has accomplished this by adding 3 more grams of protein to its original version Proteinex®. This new presentation does not contain sugar, fat, phosphorus, carbohydrates, lactose or gluten; therefore, it can be administered to patients with different conditions like gastric bypass, wound care, HIV, cancer or general malnutrition. Proteinex 18 will supply patients that have low albumin levels the required amount of protein needed in their daily diet. With only 2 tablespoons administered to the patient, he/she will receive 18 grams of predigested protein in only 72 calories. It can also be easily mixed... |
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Splenectomy (Video Atlas of General Surgery) Also With: Seymour I. Schwartz (Primary Contributor) |
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The Biology of Gastric Cancers by Timothy C. Wang (Editor), James G. Fox (Editor), Andrew S. Giraud (Editor) The purpose of this work is to provide a general and comprehensive reference work on the biology of gastric cancers for those researchers working in this area. This monograph will be written by a panel of experts in each area and represent the latest work in a series of different areas of gastric cancer research. |
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Cure Stomach (Gastric) Cancer T-shirt Large White by Shop Zeus |
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