 |
|
Oral rinses used for tracking HPV-positive head and neck cancers holds promise for cancer screening
October 31, 2008PHILADELPHIA - A study published in the journal Clinical Cancer Research, a journal of the American Association for Cancer Research, validates a non-invasive screening method with future potential for detection of human papillomavirus (HPV)-positive head and neck cancers.
In the study, researchers at Johns Hopkins University used oral rinses and targeted DNA amplification to track and identify oral HPV infections in patients with HPV16-positive and negative head and neck carcinomas (HNSCC) before and after therapy.
Findings showed detection of high-risk HPV infections in patients with HPV16-positive HNSCC for up to five years after therapy, indicating a high rate of persistent infection and reaffirming the connection between high-risk types of HPV and HPV-positive head and neck cancer.
"There is no question of cause," said the study's co-author Maura Gillison, M.D., Ph.D. associate professor of oncology. "It has now become a question of tracking the infection over time to identify those at risk of developing HPV-positive cancer, and for those who have had it, the risk of recurrence and risk of transmission. This is the first study in which we have been able to track the disease and related oral infections for an extended period of time."
Researchers obtained oral rinse samples from a group of 135 patients with head and neck carcinomas. Tissue analysis showed that 44 of these patients had HPV16-positive tumors. Both the tissue and oral rinse samples were genetically sequenced to specify the HPV variants in each. Patients with HPV16-positive tumors were significantly more likely to have oral HPV16 infections, with an almost ten-fold increase prior to therapy and a fourteen-fold increase after. Patients with high-risk oral HPV infections prior to therapy also had a 44-fold increase of post-treatment infection.
Findings showed no significant odds of tumor recurrence among those with post treatment infections and no association between these infections and the development of second primary tumors at two years. However, this possibility cannot be excluded as longer observation may be needed.
Future studies will be able to use the data and methodology to further explore the connection between HPV and head and neck cancer formation, as well as the biological factors, such as HLA type, that are involved, Gillison said.
"The big question in HPV research is centered on biological factors that cause one person to have a medical consequence from an oral HPV infection and another to be able to clear the infection without any consequences," Gillison said.
American Association for Cancer Research
"There is no question of cause," said the study's co-author Maura Gillison, M.D., Ph.D. associate professor of oncology. "It has now become a question of tracking the infection over time to identify those at risk of developing HPV-positive cancer, and for those who have had it, the risk of recurrence and risk of transmission. This is the first study in which we have been able to track the disease and related oral infections for an extended period of time."
Researchers obtained oral rinse samples from a group of 135 patients with head and neck carcinomas. Tissue analysis showed that 44 of these patients had HPV16-positive tumors. Both the tissue and oral rinse samples were genetically sequenced to specify the HPV variants in each. Patients with HPV16-positive tumors were significantly more likely to have oral HPV16 infections, with an almost ten-fold increase prior to therapy and a fourteen-fold increase after. Patients with high-risk oral HPV infections prior to therapy also had a 44-fold increase of post-treatment infection.
Findings showed no significant odds of tumor recurrence among those with post treatment infections and no association between these infections and the development of second primary tumors at two years. However, this possibility cannot be excluded as longer observation may be needed.
Future studies will be able to use the data and methodology to further explore the connection between HPV and head and neck cancer formation, as well as the biological factors, such as HLA type, that are involved, Gillison said.
"The big question in HPV research is centered on biological factors that cause one person to have a medical consequence from an oral HPV infection and another to be able to clear the infection without any consequences," Gillison said.
American Association for Cancer Research
Head And Neck Cancer Current Events and Head And Neck Cancer News RSSNew laryngoscope could make difficult intubations easier
A new tool developed by a Medical College of Georgia resident and faculty member may make it easier to place assisted breathing devices under difficult circumstances.
Rare head and neck cancer linked to HPV, study finds
An increase in cases of a rare type of head and neck cancer appears to be linked to HPV, or human papillomavirus, according to a new study from researchers at the University of Michigan Comprehensive Cancer Center.
Curcumin may inhibit nicotine-induced activation of head and neck cancers
Curcumin, the compound that gives curry powder its yellow/orange color, may inhibit the adverse effects of nicotine in patients with head and neck cancer who continue to smoke.
Study finds 231 new genes associated with head and neck cancer
A Henry Ford Hospital study has identified 231 new genes associated with head and neck cancer, one of the most deadly cancers responsible for 2.1 percent of all cancer deaths in the United States.
U of T researchers create microchip that can detect type and severity of cancer
U of T researchers have used nanomaterials to develop a microchip sensitive enough to quickly determine the type and severity of a patient's cancer so that the disease can be detected earlier for more effective treatment.
Identification of highly radiosensitive patients may lead to side effect-free radiotherapy
An international group of scientists has taken the first step on the road to targeting radiotherapy dosage to individual patients by means of their genetic characteristics.
Adding cetuximab to chemotherapy reduces advanced lung cancer death risk by 13 percent
Patients with advanced non-small cell lung cancer who are given cetuximab (Erbitux) in addition to chemotherapy are 13% less likely to die than those who receive chemotherapy alone, regardless of which chemotherapy drug cocktail is used, new research finds. They also experience slower disease progression and an increased chance of tumour shrinkage.
Prevent periodontitis to reduce the risk of head and neck cancer
Chronic periodontitis, a form of gum disease, is an independent risk factor for head and neck squamous cell carcinoma. This suggests the need for increased efforts to prevent and treat periodontitis as a possible means to reduce the risk of this form of cancer.
Prodrug could help curb skin toxicity related to EGFR-inhibiting cancer drugs
There may be a way around the harsh skin toxicity associated with a widely used cancer drug, according to a study published online this week in Cancer Biology and Therapy by researchers from City of Hope and the Kimmel Cancer at Jefferson.
Budesonide is not beneficial for the treatment of diarrhea in metastatic melanoma patients
Patients with stage III or IV melanoma taking ipilimumab and the oral steroid budesonide to reduce side effects did not have less diarrhea, a known side effect of ipilimumab.
More Head And Neck Cancer Current Events and Head And Neck Cancer News Articles
 |
Head and Neck Cancer: A Multidisciplinary Approach by Louis B Harrison (Editor), Roy B Sessions (Editor), Waun K Hong (Editor) This book employs a two-part approach to treating patients with head and neck cancer: maximize the chance for a cure while maintaining a strong emphasis on quality of life. Although not seen as commonly as other aggressive forms, head and neck cancer is a devastating disease that has tremendous implications on the overall health of the patient, as well as their appearance and quality of life. The goal of the editors was to create the first truly multidisciplinary book in this field that addresses all aspects and treatment options. The book was designed to be a comprehensive textbook crossing all disciplines and representing a wide spectrum of specialists throughout the country, including surgical, radiation, and medical oncologists, as well as dentists, pathologists, radiologists and... |
 |
Head and Neck Cancer: An Evidence-Based Team Approach by Eric Genden (Editor), Mark Varvares (Editor) Designed to synthesize the collective wisdom of a tumor board, the book presents a multidisciplinary, evidence-based approach to the contemporary management of head and neck cancer. Expert authors and contributors provide a balanced literature review that provides the reader with a solid understanding of the fundamental concepts of the disease entity, descriptions of anatomy, physiology, and clinical presentation, discussion of diagnostic workup and the various management techniques.<br><br>Highlights:<br>*Each chapter features the clinical insights of a surgeon, a medical oncologist, and a radiation oncologist<br>*Comprehensive coverage of the most important disease sites, including the oral cavity, oropharynx, hypopharynx, larynx, thyroid gland, salivary glands,... |
 |
Head and Neck Cancer Awareness Ribbon Mouse Pad by MyHeritageWear.com The Head and Neck Cancer Ribbon proudly displayed on a mouse pad. There is no better way to achieve awareness for the meaning of the Head and Neck Cancer Ribbon than to display it on your mouse pad for everyone to see. The mouse pad measures at 9.25 x 7.75, it is machine washable, and the colors will not fade or run. Start gaining awareness today by presenting your Head and Neck Cancer Ribbon mouse pad at work or at home. It is certain to keep your mouse rolling in style all while gaining support and awareness! |
 |
Radiotherapy For Head And Neck Cancers Indications And Techniques by Lippincott Williams & Wilkins Radiotherapy for Head and Neck Cancers Indications and Techniques : Radiotherapy for Head and Neck Cancers Indications and Techniques Pub Date: October 2005 Product Type: Print Author/s: K. K Ang MD, PhD; Adam S Garden MD Long established as a staple reference for all radiation oncologists, Radiotherapy for Head and Neck Cancers: Indications and Techniques is now in its Third Edition. This completely updated edition presents the state-of-the-art protocols currently used at the M.D. Anderson Cancer Center and thoroughly explains the principles, nomenclature, and clinical use of intensity-modulated radiotherapy (IMRT). New full-color illustrations have been added throughout the book.The first section discusses the practical aspects of external beam therapy,... |
 |
100 Q&A About Head and Neck Cancer (100 Questions & Answers about . . .) by Elise Carper (Author) Tumors of the head and neck afflict nearly forty thousand people annually and account for approximately five percent of all cancers. Whether you're a newly diagnosed head and neck cancer patient, a survivor, or friend or relative of either, this book offers help. The only text to provide the doctor's and patient's views, 100 Questions & Answers About Head and Neck Cancer gives you authoritative, practical answers to your questions about treatment options, post-treatment quality of life, sources of support, and much more. This is an invaluable resource for anyone coping with the physical and emotional turmoil of head and neck cancer. |
 |
Meeting the Challenges of Oral and Head and Neck Cancer: A Survivor's Guide by Nancy E. Leupold (Author), James J. Sciubba (Author), Nancy E. Leupold (Editor), James J. Sciubba (Editor) Nancy Leupold, herself a survivor, and president and founder of Support for People with Oral and Head and Neck Cancer (SPOHNC), and James J. Sciubba present an overview of the different disciplines involved in the treatment of oral and head and neck cancer, with emphasis on providing information and survivor tips to help survivors cope with the disease, its treatment, and their consequential side effects. This book takes a deliberately different stance and approach from other survivor guides, in that it concentrates on helping the individual who has completed treatment and is now on the road to recovery. Furthermore, it is unique in that it is attempting to meet the challenges of oral and head and neck cancer with specific information, in the form of lists and tables of products and... |
 |
Head And Neck Cancer A Multidisciplinary Approach by Lippincott Williams & Wilkins Head and Neck Cancer A Multidisciplinary Approach : Head and Neck Cancer A Multidisciplinary Approach Pub Date: September 2008 Product Type: Print Author/s: Louis B Harrison MD; Roy B Sessions MD; Waun K Hong MD This comprehensive, multidisciplinary text addresses all aspects of head and neck cancer and represents a wide spectrum of specialists, including surgical, radiation, and medical oncologists, dentists, pathologists, radiologists, and nurses. The book focuses on a two-part approach to treatment that maximizes the chance for a cure while maintaining a strong emphasis on quality of life.This Third Edition's updated techniques section includes new radiation techniques such as IMRT and IGRT and new endoscopic and laser surgical techniques. Other highlights include... |
 |
Head and Neck Cancer: Treatment, Rehabilitation, and Outcomes by Elizabeth C. Ward and Corina J. van As Brooks (Author), Ph.d. Ward Elizabeth C. (Editor), Ph.d. Van As Brooks Corina J. (Editor) A team of expert authors from the medical and allied health communities describe recent advances in the management of head and neck cancer through a greater understanding of cancer cell growth and mechanisms, as well as the expansion of rehabilitation strategies across the allied health profession. In addition to introducing new information, the book covers both the theoretical and clinical knowledge from an international perspective to support basic training of therapists in practice as well as graduate students, all illuminated with case examples--from swallowing disorders, through non-surgical voice restoration, to rehabilitation following total laryngeal surgery--on an accompanying CD ROM. As the first book in recent years to cover both current theory and... |
 |
Anti-Stress Microwaveable Pink Neck Pillow by Earth Therapeutics Ergonomically designed to gently drape around the neck, the Anti-Stress Neck Pillow enfolds you in its comforting embrace to relax and soothe tired, sore neck and shoulder muscles. A luxuriously soft cotton outer shell pampers and coddles while the gentle, caressing weight of the pillow does wonders to relieve tightness and stiffness in the neck, back, and shoulders. The balmy mind-calming blend of chamomile, lavender, and citrus completes and enhances these physical benefits by offering a totally relaxing, sensory experience. |
 |
Cancer of the Head and Neck by Eugene N. Myers (Editor), James Y. Suen (Editor) University of Pittsburgh, PA. Third edition of a reference on head and neck surgery for clinicians or residents. Previous edition 1989. Eight new chapters, including current information on clinical trials and developing technologies. 87 contributors, 83 U.S. Halftone illustrations and images. DNLM: Head and Neck Neoplasms. |
| © 2009 BrightSurf.com |