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Multiple sclerosis research charges ahead with new mouse model of disease
November 06, 2008A new study highlights the role of a charge-switching enzyme in nervous system deficits characteristic of multiple sclerosis and other related neurological illness.
Multiple sclerosis (MS) is one of several diseases in which myelin - the insulator for electrical signaling in the nervous system - breaks down and causes severe deficits in brain and nerve function. Much like the rubber insulation on an electrical cord, myelin surrounds long projections from the body of a neuron, and allows signals to travel down the cell with speed and efficiency. Patients with MS and other "de-myelinating" diseases therefore suffer deficits in balance, coordination, and movement, as well as sensory disturbances, from the loss of this neuronal insulation.
A major research initiative in treating these diseases is identifying the molecular factors and changes that lead to myelin breakdown. In a new study published in Disease Models & Mechanisms (DMM), dmm.biologists.org, a team of Canadian researchers report on a new mouse model of disease which will help in understanding how demyelination occurs. Previous research had identified that an enzyme known as peptidylarginine deiminase 2, or PAD2, is increased in patients with MS, and that PAD2 switches a charge on a protein key to myelin stability. Therefore, Abdiwahab A. Musse and colleagues at the University of Guelph and the Hospital for Sick Children in Ontario created a genetically modified mouse expressing too much of an enzyme known as PAD2. They found that these mice had significant loss of myelin, and also have behavioral deficits, such as abnormal movement, balance, and coordination.
Not only does this work present a new mouse model to study demyleinating disease, but it also stresses the importance of PAD in maintaining myelin integrity. Their work highlights PAD as a potential therapeutic target, as well as a potential marker for early detection of MS and other diseases characterized by a loss of myelin.
The Company of Biologists
Not only does this work present a new mouse model to study demyleinating disease, but it also stresses the importance of PAD in maintaining myelin integrity. Their work highlights PAD as a potential therapeutic target, as well as a potential marker for early detection of MS and other diseases characterized by a loss of myelin.
The Company of Biologists
Multiple Sclerosis Current Events and Multiple Sclerosis News RSSMultiple health concerns surface as winter, vitamin D deficiences arrive
A string of recent discoveries about the multiple health benefits of vitamin D has renewed interest in this multi-purpose nutrient, increased awareness of the huge numbers of people who are deficient in it, spurred research and even led to an appreciation of it as "nature's antibiotic."
Factors from common human bacteria may trigger multiple sclerosis
Current research suggests that a common oral bacterium may exacerbate autoimmune disease. The related report by Nichols et al, "Unique Lipids from a Common Human Bacterium Represent a New Class of TLR2 Ligands Capable of Enhancing Autoimmunity," appears in the December 2009 issue of The American Journal of Pathology.
Drug studied as possible treatment for spinal injuries
Researchers have shown how an experimental drug might restore the function of nerves damaged in spinal cord injuries by preventing short circuits caused when tiny "potassium channels" in the fibers are exposed.
CSHL team solves structure of NMDA receptor unit that could be drug target for neurological diseases
A team of scientists at Cold Spring Harbor Laboratory (CSHL) reports on Thursday their success in solving the molecular structure of a key portion of a cellular receptor implicated in Alzheimer's, Parkinson's, and other serious illnesses.
Men leave: Separation and divorce far more common when the wife is the patient
A woman is six times more likely to be separated or divorced soon after a diagnosis of cancer or multiple sclerosis than if a man in the relationship is the patient, according to a study that examined the role gender played in so-called "partner abandonment." The study also found that the longer the marriage the more likely it would remain intact.
Neurologists Investigate Possible New Underlying Cause of MS
Neurologists at the University at Buffalo are beginning a research study that could overturn the prevailing wisdom on the cause of multiple sclerosis (MS).
Scientists demonstrate link between genetic defect and brain changes in schizophrenia
Researchers at the University of North Carolina at Chapel Hill School of Medicine have found that the 22q11 gene deletion - a mutation that confers the highest known genetic risk for schizophrenia - is associated with changes in the development of the brain that ultimately affect how its circuit elements are assembled.
Gentle touch may aid multiple sclerosis patients
While gripping, lifting or manipulating an object such as drinking from a cup or placing a book on a shelf is usually easy for most, it can be challenging for those with neurological diseases such as multiple sclerosis or Parkinson's, or for people who had a stroke. For them, the tight gripping can cause fatigue, making everyday tasks difficult.
Urate in blood and spinal fluid may predict slower decline in patients with Parkinson's disease
Higher concentration of urate (an antioxidant) in the blood and spinal fluid of patients with early Parkinson's disease is associated with slower rates of clinical decline.
Oxidized form of a common vitamin may bring relief for ulcerative colitis
New research published in the Journal of Leukocyte Biology finds retinoic acid may alleviate ulcerative colitis and similar irritable bowel diseases.
More Multiple Sclerosis Current Events and Multiple Sclerosis News Articles
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The First Year: Multiple Sclerosis: An Essential Guide for the Newly Diagnosed by Margaret Blackstone (Author), M.D. Saud A. Sadiq (Foreword) One of the most widely recommended guides to living with multiple sclerosis, now completely revised and updated, including the latest research, the most recent information on treatments (including the news on Tysabri®), and new tips for managing MS. Multiple sclerosis is as much a mystery as it is a disease, but this chronic and often disabling condition of the central nervous system affects over 400,000 people nationwide. From the moment of her diagnosis in 2000, Margaret Blackstone took charge and educated herself on every aspect of her condition. Now, as a "patient-expert," she guides those newly diagnosed step-by-step through their first year with MS. She provides crucial information about: The most up-to-date treatment options Effective alternative therapies Choosing the right... |
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Healing Multiple Sclerosis: Diet, Detox & Nutritional Makeover for Total Recovery by Ann Boroch (Author), Ann Louise Gittleman (Foreword) Multiple Sclerosis can now be healed and this book shows you how. Though MS is widely believed to be incurable, Boroch's breakthrough treatment protocol can dramatically restore patients to health. This landmark book describes her own tumultuous journey with MS: • Her quest for a cure • Case histories of those who have triumphed over MS • The real causes of MS • How to develop a personal treatment plan • Everything you need to bring about recovery, including a detailed and effective self-help treatment protocol • Delicious recipes and recommended foods, with two weeks of sample menus • A five-week nutritional makeover, recommended supplements and a daily sample supplement schedule • A list of recommended products • User-friendly charts and resources |
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The MS Recovery Diet by Ann Sawyer (Author), Judith Bachrach (Author) More than half a million people live with multiple sclerosis, yet conventional medicine still has little to offer patients. There is no known cure-and even recent breakthroughs in drug therapy do not work to control many of the symptoms or promise any degree of recovery. But there is an alternative to drugs that can stop and reverse the ravaging symptoms of MS-the MS Recovery Diet. As this book explains, there are five common food triggers that can set off the symptoms of MS-dairy, grains containing glutens, legumes, eggs, and yeast. Yet because MS is such a complex disease, other foods play a role, as culprits or aides. The MS Recovery Diet explains the background, science, and development of this treatment in one source for the first time, and shows readers how to pinpoint their... |
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Multiple Sclerosis Q & A: Researching Answers to Frequently Asked Questions by Beth Ann Hill (Author) An insightful, informative, and empathic resource for learning to live well with multiple sclerosis. This comprehensive yet accessible work provides authoritative and reassuring answers to the many questions that overwhelm those undergoing testing and treatment for multiple sclerosis. It discusses traditional and complementary therapies for MS; explains medical terminology and diagnostics; and compassionately addresses the lifestyle changes many patients face while learning to manage this chronic and potentially debilitating disorder. |
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Multiple Sclerosis For Dummies (For Dummies (Health & Fitness)) by Rosalind Kalb Ph.D. (Author), Nancy Holland RN EdD MSCN (Author), Barbara Giesser MD (Author), David L. Lander (Foreword) Being diagnosed with multiple sclerosis (MS) doesn’t have to mean your life is over. Everyone’s MS is different and no one can predict exactly what yours will be like. The fact is, lots of people live their lives with MS without making a full-time job of it. MS for Dummies gives you easy to access, easy to understand information about what happens with MS—what kinds of symptoms it can cause, how it can affect your life at home and at work, what you can do to feel and function up to snuff, and how you can protect yourself and your family against the long-term unpredictability of the disease. You'll learn: Why some people get MS and others don’t How to make treatment and lifestyle choices that work for you What qualities to look for in a... |
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Complementary and Alternative Medicine and Multiple Sclerosis by M.D. Allen C. Bowling Ph.D (Author) The first edition of this authoritative book quickly became the single source for accurate and unbiased information on complementary and alternative medicine approaches for the management of MS symptoms. The second edition, completely updated throughout, reflects advances in the field since the book’s initial publication in 2001. Therapies are organized alphabetically so that readers can easily pinpoint a specific treatment and learn about its origins, merits, and possible uses in MS. In-depth discussions cover Naltrexone, acupuncture, biofeedback, chiropractic medicine, cooling therapy, yoga, diets, the use of supplements, herbs, vitamins, and minerals, and many other topics. This invaluable guide alerts MS patients and their families to new options for relief when conventional... |
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Multiple Sclerosis: New Hope and Practical Advice for People with MS and Their Families by Louis Rosner (Author), Shelley Ross (Author) The most trusted book on multiple sclerosis, updated and revised with the latest research in combating the disease Once known as the "crippler of young adults," now more than 75 percent of MS patients will never need a wheelchair. In Multiple Sclerosis, Dr. Louis J. Rosner and Shelley Ross explain that there genuinely is new hope, more than ever before, both for controlling the disease today and curing it tomorrow. Updated with the latest research and terminology, this revised edition gets to the bottom of every treatment option from the tried-and-true to today's cutting-edge and experimental therapies. Its trusted advice covers every step of living with MS, what you need to know, and what you need to ask. Dr. Louis Rosner and Shelley Ross explain what the disease is, who gets it and... |
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MS and Your Feelings: Handling the Ups and Downs of Multiple Sclerosis by Allison Shadday LCSW (Author), Stanley Cohan (Foreword) MS and Your Feelings is the first book to specifically address the emotional pain caused by the unpredictable, disabling chronic inflammatory condition multiple sclerosis. Psychotherapist and MS patient Allison Shadday offers readers effective strategies for dealing with the psychological trauma of this disease. Shadday shares real-life MS success stories and gives insightful professional advice derived from years of counseling hundreds of chronically ill patients. Her book offers readers hope, inspiration and validation, teaching them how to come to terms with an MS diagnosis; strategies for identifying and managing stress triggers; ways to cope with fear, guilt, anger, loss, depression, and isolation; steps to enhance intimacy and develop a greater sense of emotional security; and more.... |
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Exercises for Multiple Sclerosis: A Safe and Effective Program to Fight Fatigue, Build Strength, and Improve Balance by Brad Hamler (Author) Fight the impact of MS through fitness with specially designed exercises. In the U.S. alone, approximately 400,000 people have multiple sclerosis (MS). MS is an autoimmune disease that affects the central nervous system. There are a variety of symptoms of MS and it affects people in different ways, but there is no cure. Fitness can help strengthen debilitated bodies, and make living with the disease a little easier. Exercises for Multiple Sclerosis outlines a detailed exercise plan that can help MS sufferers overcome their symptoms, especially fatigue and mobility problems. The latest book in the popular Exercises for series, Exercises for Multiple Sclerosis provides a tested program for people living with MS, making it an essential reference for anyone who suffers from... |
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The Everything Health Guide to Multiple Sclerosis: An authoritative guide to help you understand symptoms, decide on treatment, and enhance your well-being (Everything Series) by Margot Russell (Author), Allen C Bowling (Author) The National Multiple Sclerosis Society estimates that 400,000 people in the United States have been diagnosed with MS. Because MS is a chronic disease, people with this diagnosis will live with the disease for years. MS sufferer Margot Russell and Dr. Allen C. Bowling, a nationally known MS expert, team up to help readers: Recognize signs and symptoms; understand the types of MS; decide on treatment and find the right doctor; explore alternative therapies; take charge by creating a management plan; develop strength and avoid relapse; and more. Filled with tips for daily living (like staying cool) and the latest information on new treatments, this reassuring book offers more than medical advice. It gives readers with MS the strength, knowledge, and resources they need so they can live a... |
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