 |
|
Study shows direct link between leptin and obesity-related cardiovascular disease
November 11, 2008Obese people who don't have high cholesterol or diabetes might think they're healthy - despite the extra pounds. But new Ohio University research suggests that obesity raises levels of the hormone leptin, which can be as big a threat to the cardiovascular system as cholesterol.
Tadeusz Malinski and colleagues have published the first study to directly observe how high levels of leptin can create a cascade of harmful biochemical changes in the body. Leptin, a peptide hormone produced by fat cells, helps regulate body weight by acting on the hypothalamus to suppress appetite and burn stored fat.
But an excess of fat in the body can produce too much of the hormone, which, in turn, can lower levels of bioavailable nitric oxide. Nitric oxide, produced by the endothelial cells, supports healthy cardiovascular function by relaxing blood vessels and maintaining good blood flow, explained Malinski, who has developed special nanosensors that can detect levels of the substance.
In addition, Malinski found that the high levels of leptin stimulate greater production of superoxide. It reacts with nitric oxide to create peroxynitrite, a very toxic molecule that can impact DNA replication and damage endothelial cells in the vascular system.
"The nanosensors provide a more direct method of determining what processes are occurring in the body. Previously, researchers didn't have a clear idea of how this works," said Malinski, the Marvin and Ann Dilley White Distinguished Professor of Biomedical Sciences at Ohio University.
The study, which examined the process in single human cells and also obese mice models, was published in a recent issue of the American Journal of Physiology - Heart and Circulatory Physiology.
Though obesity is closely associated with heart failure, scientists haven't fully understood the relationship, Malinski noted. The new study suggests that increased levels of leptin alone can cause long-term cardiovascular damage similar to hypertension, arthrosclerosis, diabetes and other disorders.
"Now that we know the exact molecules responsible for the damage, we can design a method to mollify the effect of obesity on the cardiovascular system," Malinski said.
The study was funded by the National Heart, Lung and Blood Institute, the Marvin White Endowment and the Biomimetic Nanoscience and Nanotechnology Program at Ohio University.
Co-authors on the study were Mykhaylo Korda and Ruslan Kubant, both research associates in the Malinski lab at Ohio University.
Ohio University
In addition, Malinski found that the high levels of leptin stimulate greater production of superoxide. It reacts with nitric oxide to create peroxynitrite, a very toxic molecule that can impact DNA replication and damage endothelial cells in the vascular system.
"The nanosensors provide a more direct method of determining what processes are occurring in the body. Previously, researchers didn't have a clear idea of how this works," said Malinski, the Marvin and Ann Dilley White Distinguished Professor of Biomedical Sciences at Ohio University.
The study, which examined the process in single human cells and also obese mice models, was published in a recent issue of the American Journal of Physiology - Heart and Circulatory Physiology.
Though obesity is closely associated with heart failure, scientists haven't fully understood the relationship, Malinski noted. The new study suggests that increased levels of leptin alone can cause long-term cardiovascular damage similar to hypertension, arthrosclerosis, diabetes and other disorders.
"Now that we know the exact molecules responsible for the damage, we can design a method to mollify the effect of obesity on the cardiovascular system," Malinski said.
The study was funded by the National Heart, Lung and Blood Institute, the Marvin White Endowment and the Biomimetic Nanoscience and Nanotechnology Program at Ohio University.
Co-authors on the study were Mykhaylo Korda and Ruslan Kubant, both research associates in the Malinski lab at Ohio University.
Ohio University
Leptin Current Events and Leptin News RSSScientists find obesity alone does not cause arthritis in animals
The link between obesity and osteoarthritis may be more than just the wear and tear on the skeleton caused by added weight.
Researchers identify new brain pathway for regulating weight and bone mass
Contrary to the prevailing view, the hormone leptin, which is critical for normal food intake and metabolism, appears to regulate bone mass and suppress appetite by acting mainly through serotonin pathways in the brain.
Fish fend off invading germs with an initial response similar to the one found in people
Since the human response to infection is highly complex, research to understand how people fight infection is facilitated by studying how similar processes occur in simpler organisms.
Ice cream may target the brain before your hips, UT Southwestern study suggests
Blame your brain for sabotaging your efforts to get back on track after splurging on an extra scoop of ice cream or that second burger during Friday night's football game.
New information about how fat increases blood pressure could help identify those at risk
Some of the first information about how fat causes hypertension have been identified by researchers who say the findings should one day help identify which obese people - and maybe some thin ones too - are at risk for hypertension and which drugs would work best for them.
Caltech researchers pinpoint neurons that control obesity in fruit flies
A team of scientists from the California Institute of Technology (Caltech) have pinpointed two groups of neurons in fruit fly brains that have the ability to sense and manipulate the fly's fat stores in much the same way as do neurons in the mammalian brain.
Scarring key to link between obesity and diabetes
The team, in collaboration with University Hospital Aintree, the University of Warwick and researchers in Sweden, found that people classified as obese and those with pre-diabetes have raised levels of a protein called SPARC, that can cause tissue scarring.
Obesity increases risk of prostate cancer recurrence for both blacks and whites
A new look at a large database of prostate cancer patients shows that obesity plays no favorites when it comes to increasing the risk of recurrence after surgery: Being way overweight is equally bad for blacks and whites, say researchers at Duke University Medical Center.
Study further expands understanding of leptin's role in brain neurocircuitry
In investigating the complex neurocircuitry behind weight gain and glucose control, scientists have known that the hormone leptin plays a key role in the process.
Sleep may be factor in weight control
Could sleep be a critical component to maintaining a healthy body weight?
More Leptin Current Events and Leptin News Articles
 |
Mastering Leptin: Your Guide to Permanent Weight Loss and Optimum Health (Third Edition) by Byron J. Richards (Author), Mary Guignon Richards (Author) First published in 2002, Mastering Leptin is the first and most in-depth book explaining the hormone leptin and its relationship to obesity and difficult weight loss, yo-yo dieting, low energy, heart disease, low thyroid, stress eating, food cravings, and hormonal imbalance. Mastering Leptin cuts through the confusion of countless ways to eat and provides individuals with a workable lifestyle for permanent weight loss. Renowned leptin expert Byron Richards, CCN analyzes over 8,500 leptin-related scientific studies and brings amazing findings to the public in an easy-to-understand format. Learn how to eat in harmony with the fat hormone leptin, reduce food cravings, improve energy, and permanently lose weight. |
 |
The Leptin Diet: How Fit Is Your Fat? (Take Charge) by Byron J. Richards (Author) The Leptin Diet explains how to unleash the power of hormones to resolve fatigue, food cravings, thyroid problems, and body weight issues. Mastering the fat hormone leptin is the single most important factor in preventing obesity, diabetes, and heart disease. The Leptin Diet contains five simple lifestyle guidelines to get the hormone leptin into balance for permanent weight loss, increased energy, and optimum health. What is Leptin? Fat cells produce the powerful hormone leptin, a primary force instructing metabolism, weight loss, and hormone balance. Leptin communicates directly to your brain, telling the brain how much fat is in storage. It controls appetite, energy, and metabolic rate. Leptin problems are the primary reason for food cravings, overeating, faulty metabolism, the... |
 |
The Fat Resistance Diet: Unlock the Secret of the Hormone Leptin to: Eliminate Cravings, Supercharge Your Metabolism, Fight Inflammation, Lose Weight & Reprogram Your Body to Stay Thin- by Leo Galland (Author) No more counting carbs, calories, or fat grams! This revolutionary diet plan works with your hormones to curb your appetite, boost your metabolism, and take the pounds off for good! Cutting-edge research shows that losing weight is not about carbs, calories, or even willpower—it’s about a hormone called leptin, and how it functions in your body. Leptin is your body’s natural weight-loss mechanism: it curbs your appetite, jump-starts your metabolism, and when working properly makes you literally fat resistant—you will lose weight effortlessly and efficiently and never gain those pounds back. If you’re struggling to lose weight, chances are you are “leptin resistant”—your body no longer responds to leptin, making it impossible for you to slim down. The Fat... |
 |
Lepti-Trim 180 ct with Leptin Get Slim and Trim by Immune Tree In 1994, researchers discovered a small hormone-like protein called leptin, that orchestrates the metabolism of fat and suppresses appetite. By the year 2000, researchers had uncovered the process by which leptin, working in conjunction with IgF-1 and other natural co-factors, can help restore fat cells to their normal size and increase the rate of thermogenesis. Both leptin and IgF-1 are found in complete colostrum, along with an array of co-factors that work together to reduce body fat and build lean muscle. Lepti-Trim combines enhanced levels of leptin and IgF-1, with additional co-factors to promote healthy fat and inch loss |
 |
The Leptin Boost Diet: Unleash Your Fat-Controlling Hormones for Maximum Weight Loss by Scott Isaacs (Author) A series of recent medical breakthroughs have confirmed what physicians suspected all along — obesity is a hormonal disorder. The Leptin Boost Diet transforms these findings into a unique and easy-to-follow weight-loss program that is perfect for people whose out-of-balance hormones make it impossible to lose weight on other diets. The book shows how to optimize leptin and other fat cell hormones so that the body’s natural chemistry becomes an ally, instead of a barrier, in the fight against fat. Dr. Scott Isaacs, an expert in the field, clearly explains complex topics relating to the newest medical treatments, the endocrinology of fat cell hormones, identifying leptin deficiency, and improving the action of leptin in the body. His program includes clear and concise recommendations on... |
![Leptin, hunger, and body weight: Influence of gender, tobacco smoking, and smoking abstinence [An article from: Addictive Behaviors]](http://ecx.images-amazon.com/images/I/41J08AVSFVL._SL160_.jpg) |
Leptin, hunger, and body weight: Influence of gender, tobacco smoking, and smoking abstinence [An article from: Addictive Behaviors] by L. Cousino Klein (Author), E.J. Corwin (Author), R.M. Ceballos (Author) This digital document is a journal article from Addictive Behaviors, published by Elsevier in 2004. The article is delivered in HTML format and is available in your Amazon.com Media Library immediately after purchase. You can view it with any web browser. Description: Leptin is a hormone involved in body weight and hunger regulation, and may contribute to the inverse relationship between cigarette smoking and body weight. Leptin levels, body mass indices (BMIs), and hunger ratings were determined in 22 nonsmokers (12 male, 10 female) and 19 cigarette smokers (11 male, 8 female). Smokers were tested after ad lib smoking and following a 24-h smoking abstinence period; nonsmokers came to the laboratory once. Leptin levels were not different among the groups. Hunger ratings,... |
 |
Leptin (Endocrine Updates) by V. Daniel Castracane (Editor), Michael C. Henson (Editor) There are more than 8,000 references in the literature on leptin. Nearly 6,000 of these references are from 2000 to the present, the remaining date back only to 1996. The discovery of this protein hormone has received great interest since leptin effects regulation of body weight, metabolism and reproductive function. This book is an edited collection beginning with the discovery of leptin and a study of its affect on animals and in humans. Chapters will focus on the discovery, history, roles and regulation of leptin in all the major areas of physiology, as well as on assay methods, phylogeny and genetics. |
 |
The Rosedale Diet by Ron Rosedale (Author), Carol Colman (Author) Finally—the ultimate diet for fast, safe weight loss, lifelong health, and longer life, based on more than twenty years of research and the latest findings on appetite and weight. Metabolic specialist Ron Rosedale, M.D., has designed the Rosedale Diet to regulate the powerful hormone leptin, which controls appetite and weight loss by telling the brain when to eat, how much to eat—and when to stop. New research shows that leptin may be one of the body's most important hunger control mechanisms. Control leptin, and you control your weight. Most people's leptin levels are out of control, causing them to overeat and to store fat rather than burn it. The only way to flip the "hunger switch" back to normal is through a diet high in healthy fats and low in carbohydrates, saturated... |
 |
Lepti-Trim Night Time Formula (16 oz) by Total Body Research Labs The Lepti-Trim unique Night Time Formula recognizes what other products and programs do not: you need to replace the suppementation your body periodically eliminates. And since the Lepti-Trim System improves elimination, you especially need this Night Time Formula. Insulin levels are lower while you sleep which allows Lepti-Trim to be especially effective. The Lepti-Trim System is a scientific breakthrough providing inch loss, weight management, and a feeling of light, bright, clean functionality available only from Lepti-Trim. Leptin is a TBR Labs science discovery that orchestrates the body's use of fats to accelerate weight maintenance and inch loss. Containing a proprietary blend of vitamins, minerals, enzymes, and amino acids, Lepti-Trim nourishes the body to reduce cravings... |
![The Leptin Diet: How Fit Is Your Fat? [LEPTIN DIET]](http://ecx.images-amazon.com/images/I/41Inpsm9xoL._SL160_.jpg) |
The Leptin Diet: How Fit Is Your Fat? [LEPTIN DIET] by Byron J.(Author) Richards (Author) |
| © 2009 BrightSurf.com |