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A Simple Blood Test for Colon Cancer
November 21, 2008People are often reluctant to undergo a routine but painful colonoscopy ― but the consequences can be fatal. According to the American Cancer Society, colon cancer is the third most common cancer found in American men and women and kills about 50,000 Americans every year.
"85% of those who develop colon cancer have no symptoms or family history," says Prof. Nadir Arber, a professor of medicine and gastroenterology, at Tel Aviv University's Sackler Faculty of Medicine. "Generally speaking, it's much harder to get these people to comply with taking the test."
To convince more people to undergo the potentially life-saving colonoscopy, Prof. Arber has developed a simple early-warning test that can detect colon cancer in the blood. Using biomarkers, it is the first test on the market that can detect cells of colon polyps the precursors to colon cancer in the blood, with a very high degree of sensitivity and accuracy.
This painless, non-invasive and inexpensive test could very well be a breakthrough of the decade.
An Attractive Diagnostic Step
"If we can identify those who are prone to cancer through a less invasive test, we can convince them to do the colonoscopy," leading to earlier detection and treatment, says Prof. Arber, who heads the Integrated Cancer Prevention Center at the Tel Aviv Souraski Medical Center.
Now being prepared for the market by Bio Mark Ltd., a subsidiary of Micromedic Technologies Ltd., Prof. Arber's "CD24" test could begin to save thousands of Americans' lives by as early as 2010. With the test, doctors can catch polyp growth in the colon in 80% of patients.
The American Cancer Society suggests that all Americans over the age of 50 receive periodic colonoscopies. With Prof. Arber's test, doctors will be able to screen patients for colon cancer quickly and easily as part of a routine blood test. While not 100% accurate, it will provide a convincing argument for patients to undergo the colonoscopy, and then polyp removal, if necessary.
The novel invention is based on testing CD24, the oncogene for colorectal cancer. It utilizes the fact that polyps in the colon emit biomarkers, which can be detected in the blood at very low levels. Recent studies show that the test can correctly identify adenomas, the polyps that convert to colon cancer, at a success rate of more than 80%.
Some patients forego colonoscopy not just out of fear or distaste, but due to its high cost. Here, too, the breakthrough is significant. While traditional colonoscopies cost about about $1,500 per test, Prof. Arber's procedure is expected to cost much less ― $50 to $100 per test.
Prevention Is Still the Best Medicine
Prof. Arber recommends a number of preventative steps against colon cancer, especially by those at risk. "There are some lifestyle choices people can make to prevent malignancies," he says. "Eating well, exercise, and avoiding smoking and drinking are very important."
Prof. Arber is also working on a drug that prevents the growth of polyps in the colon.
American Friends of Tel Aviv University
This painless, non-invasive and inexpensive test could very well be a breakthrough of the decade.
An Attractive Diagnostic Step
"If we can identify those who are prone to cancer through a less invasive test, we can convince them to do the colonoscopy," leading to earlier detection and treatment, says Prof. Arber, who heads the Integrated Cancer Prevention Center at the Tel Aviv Souraski Medical Center.
Now being prepared for the market by Bio Mark Ltd., a subsidiary of Micromedic Technologies Ltd., Prof. Arber's "CD24" test could begin to save thousands of Americans' lives by as early as 2010. With the test, doctors can catch polyp growth in the colon in 80% of patients.
The American Cancer Society suggests that all Americans over the age of 50 receive periodic colonoscopies. With Prof. Arber's test, doctors will be able to screen patients for colon cancer quickly and easily as part of a routine blood test. While not 100% accurate, it will provide a convincing argument for patients to undergo the colonoscopy, and then polyp removal, if necessary.
The novel invention is based on testing CD24, the oncogene for colorectal cancer. It utilizes the fact that polyps in the colon emit biomarkers, which can be detected in the blood at very low levels. Recent studies show that the test can correctly identify adenomas, the polyps that convert to colon cancer, at a success rate of more than 80%.
Some patients forego colonoscopy not just out of fear or distaste, but due to its high cost. Here, too, the breakthrough is significant. While traditional colonoscopies cost about about $1,500 per test, Prof. Arber's procedure is expected to cost much less ― $50 to $100 per test.
Prevention Is Still the Best Medicine
Prof. Arber recommends a number of preventative steps against colon cancer, especially by those at risk. "There are some lifestyle choices people can make to prevent malignancies," he says. "Eating well, exercise, and avoiding smoking and drinking are very important."
Prof. Arber is also working on a drug that prevents the growth of polyps in the colon.
American Friends of Tel Aviv University
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Colon Cancer Current Events and Colon Cancer News RSSColorectal cancer
Previously, only a few genes had been associated with the formation of metastases in colorectal cancer. Now, researchers of the Max Delbrück Center for Molecular Medicine (MDC) Berlin-Buch and Charité - University Medicine Berlin, Germany, have identified 115 genes that are disregulated both in the primary tumor and in its metastases.
Study finds improved communication encourages patients to seek colorectal cancer screening
Improved communication among patients and primary care physicians increases the chances those due for colorectal cancer screening will follow their doctors' advice and complete the procedure, a University at Buffalo study has found.
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Colon Cancer Screening Technique Shows Continued Promise in New Study
Recent clinical trials show that a new colon cancer screening technique created by Northwestern University researchers has a high enough sensitivity that it could potentially be as or more successful than a colonoscopy in screening for colon cancer.
Women under-represented in cancer research, U-M study finds
Women are under-represented in clinical cancer research published in high-impact journals, according to a new study by researchers at the University of Michigan Comprehensive Cancer Center.
Improved DNA stool test could detect digestive cancers in multiple organs
Mayo Clinic researchers have demonstrated that a noninvasive screening test can detect not only colorectal cancer but also the common cancers above the colon -- including pancreas, stomach, biliary and esophageal cancers.
Chemotherapy combination outcomes differ for aged, younger colon cancer patients
he combination of chemotherapies 5FU and oxaliplatin compared to 5FU alone after surgery for colon cancer decreases colon cancer recurrence and promotes longer survival for patients under 70 -- but not for those who are older.
1 in 10 advanced colon cancer patients worry about prescription drug costs
The vast majority of advanced colon cancer patients in a clinical trial were not concerned about the cost of prescription drugs for managing chemotherapy side effects, such as infection, pain and nausea and few adopted strategies to reduce drug cost burdens after joining the clinical trial.
Obesity predicts inadequate bowel prep at colonoscopy
Obesity is an independent predictor of inadequate bowel preparation at colonoscopy, and the presence of additional risk factors further increases the likelihood of a poorly cleansed colon.
Caffeic acid inhibits colitis in a mouse model -- is a drug-metabolizing gene crucial?
Researchers at Iowa State University have found that increased expression of a form of cytochrome P-450 (CYP4B1) is a key marker of inhibition of colitis in mice by caffeic acid, an anti-inflammatory antioxidant compound widely distributed in foods.
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