 |
|
HER2 levels may aid in treatment selection for metastatic breast cancer
December 03, 2008PHILADELPHIA - Findings published in the December 1, 2008, issue of Clinical Cancer Research, a journal of the American Association for Cancer Research, show lapatinib benefits women with HER2-positive breast cancer, while women with HER2-negative breast cancer or those who express EGRF alone derive no incremental benefit. In addition, a misclassification of metastatic breast cancer patients by as much as 10 percent prevents some people from receiving optimal therapy.
Lapatinib, an oral chemotherapy agent, inhibits both HER2 and EGRF receptors, leaving unanswered questions about which patients are more likely to benefit. Researchers at the Norris Comprehensive Cancer Center found that HER2 amplification ("HER2-positive"), but not EGRF expression, is correlated with responsiveness to lapatinib. Women with both high and low levels of HER2 amplification respond to lapatinib. However, women with HER2-negative metastatic breast cancers do not respond.
Women with HER2-postitive metastatic breast cancer who receive lapatinib and chemotherapy have shown an improvement of approximately 50 percent in progression-free survival when compared to chemotherapy alone. Unfortunately, high volume laboratories using laboratory technicians instead of pathologists to score gene amplification misclassify approximately 10 percent of HER2 amplified breast cancers as not amplified, preventing these patients from being candidates for lapatinib.
"I would like to see all women with breast cancer tested appropriately, using the best method and certified personnel, to assess the HER2 status of their breast cancer so the appropriate treatment can be selected," said Michael Press, M.D., Ph.D., Norris Comprehensive Cancer Center Harold E. Lee Chair in Cancer Research and lead author of the study.
Currently lapatinib is approved by the FDA for use only in women who have HER2-positive metastatic breast cancer who were previously treated with anthracyclines, trastuzumab and taxane.
American Association for Cancer Research
"I would like to see all women with breast cancer tested appropriately, using the best method and certified personnel, to assess the HER2 status of their breast cancer so the appropriate treatment can be selected," said Michael Press, M.D., Ph.D., Norris Comprehensive Cancer Center Harold E. Lee Chair in Cancer Research and lead author of the study.
Currently lapatinib is approved by the FDA for use only in women who have HER2-positive metastatic breast cancer who were previously treated with anthracyclines, trastuzumab and taxane.
American Association for Cancer Research
Breast Cancer Current Events and Breast Cancer News RSSUCLA researchers create 'fly paper' to capture circulating cancer cells
Just as fly paper captures insects, an innovative new device with nano-sized features developed by researchers at UCLA is able to grab cancer cells in the blood that have broken off from a tumor.
Fertility procedures need not delay breast cancer treatment for younger women
A new study published in the November issue of the Journal of the American College of Surgeons shows that breast cancer patients under 40 years old who undergo fertility preservation do not face a significant delay in the treatment of their disease when their care is coordinated in a timely fashion.
Coffee break: Compound brewing new research in colon, breast cancer
A compound in coffee has been found to be estrogenic in studies by Texas AgriLife Research scientists.
Drugs to treat anemia in cancer patients linked to thromboembolism
Medications frequently given to cancer patients to reduce their risk of anemia are associated with an increased risk of deep vein thrombosis or pulmonary embolism, according to new research led by Dawn Hershman, M.D, M.S., co-director of the breast cancer program at the Herbert Irving Comprehensive Cancer Center at NewYork-Presbyterian Hospital/Columbia University Medical Center.
Discovery in worms by Queen's researchers points to more targeted cancer treatment
Researchers at Queen's University have found a link between two genes involved in cancer formation in humans, by examining the genes in worms. The groundbreaking discovery provides a foundation for how tumor-forming genes interact, and may offer a drug target for cancer treatment.
FDA approved leukemia drugs shows promise in ovarian cancer cells
The drug Sprycel, approved for use by the U.S. Food and Drug Administration in patients with chronic myeloid leukemia, significantly inhibited the growth and invasiveness of ovarian cancer cells and also promoted their death, a study by researchers with UCLA's Jonsson Comprehensive Cancer Center found.
Carnegie Mellon researchers link health-care debate to risk of dying in US and Europe
The current health care debate in the United States is complicated. Trade-offs between heath care expenditures, lifestyle choices and life expectancy have been suggested but seldom clearly demonstrated.
Scientists uncover new key to the puzzle of hormone therapy and breast cancer
The use of postmenopausal hormone therapy has decreased over time in the United States, which researchers suggest may play a key role in the declining rate of atypical ductal hyperplasia, a known risk factor for breast cancer.
Breast density associated with increased risk of cancer recurrence
A new study finds that women treated for breast cancer are at higher risk of cancer recurrence if they have dense breasts. Published in the December 15, 2009 issue of Cancer, a peer-reviewed journal of the American Cancer Society, the study's results indicate that breast cancer patients with dense breasts may benefit from additional therapies following surgery, such as radiation.
Researcher: 'Optical biopsy' for breast cancer increasingly accurate
But women may not have to endure the medical costs, stress and potential complications that accompany such invasive biopsies forever. A University of Florida biomedical engineering researcher is making progress on an "optical biopsy" that has the potential to determine whether growths are cancerous without ever puncturing the skin.
More Breast Cancer Current Events and Breast Cancer News Articles
 |
New Balance Women's Lace Up X Out Breast Cancer Tech Tee (Athletic Grey, Small) by New Balance The New Balance X Out Breast Caner Tee has a soft hand and clearly states how everyone feels! |
 |
Breast Cancer Survival Manual, Fourth Edition: A Step-by-Step Guide for the Woman With Newly Diagnosed Breast Cancer by John Link (Author) A completely updated edition of the definitive guide for patients with breast cancer The new fourth edition of The Breast Cancer Survival Manual provides essential updates on treatment and care, enhancing the basic information that has made this the most trusted guide for women diagnosed with breast cancer for the past decade. This edition includes the most current advice on • getting a second opinion: why it’s important, what questions to ask, and how to decide which team of doctors is best for you • updates on genetic testing and how doctors are using the results to tailor care for each patient • navigating new types of radiation, the herceptin breakthrough, and improved reconstruction surgeries Conscious of the rapidly evolving spectrum of... |
 |
Sunbeam SlumberRest Camelot Microplush Heated Throw, Breast Cancer Awareness Pink by Sunbeam Soft comfortable fabric that you can cuddle up with anywhere in your house. Use it on the couch while curling up to read a good book or in a chair while watching your favorite show. This throw is 50"x60", with a primstyle control which features 3 warming settings and 3 hour auto-off. So turn on your warming blanket, turn off your thermostat and save on your heating bill. Warm up to a good cause! Sunbeam is joining the fight against breast cancer. Through the purchase of this pink throw, sunbeam will donate $1.00 to city of hope for breast cancer research, treatment and education* up to $25,000. Program ends april 30, 2009. "to save lives and end breast cancer forever by empowering people, ensuring quality care for all, and energizing science to find the cures." *to learn more about... |
 |
1149 WOMENS VINTAGE BLACK ADJUSTABLE FATIGUE CAP w/PINK STRIPES & ''BREAST CANCER'' RIBBON by Rothco A portion of these proceeds go to the Babylon Breast Cancer Coalition- For Life, For Hope, For Change, For the Future Visit www.babylonbreastcancer.org for more information. |
 |
Hope Courage Strength Pink Ribbon Breast Cancer Awareness Expressively Yours Bracelet by MyJewelThief |
 |
Wrangler Women's Tough Enough To Wear Pink Breast Cancer Awareness Jacket,Pink,X-Large by Wrangler Are you tough enough to wear pink? That is the question the western industry asked 12/9/05 at the Wrangler National Finals Rodeo (Wrangler NFR), the "Super Bowl of pro rodeo," as it launched Tough Enough to Wear Pink (TETWP). TETWP is a multi-year, western-industry-wide fundraiser to raise awareness and funds for breast cancer research. TETWP partners are ponying up to support this cause by manufacturing pink merchandise with proceeds benefiting breast cancer research. By wearing this Tough Enough to Wear Pink shirt you are helping in the fight against breast cancer. This TETWP shirt is a pink cotton plaid. Import. Tough Enough to Wear Pink. long sleeve zip front jacket with zippered front slash pockets and the breast cancer embroidery on left chest. 100% Polyester Fleece/100% Nylon... |
 |
Raymond Geddes National Breast Cancer Foundation Pen (67709) by Raymond Geddes Breast Cancer Awareness Pen, Join Geddes in supporting the National Breast Cancer Foundation and the fight against Breast Cancer. Assortment contains pink pens with pink ribbons. Retractable, black in pen ink. 5 1/2" long. |
 |
Just Get Me Through This!: The Practical Guide to Breast Cancer by Deborah A. Cohen (Author), M.D., Robert M. Gelfand (Author) |
 |
Thermos Intak Breast Cancer Awareness 26-Ounce Hydration Bottle by Thermos Nissan Thermos Intak breast cancer awareness hydration bottle is made from bpa free, impact- resistant, dishwasher durable eastman tritan copolyester. The leak-proof lid has an integrated carrying loop. Ideal for water, iced tea, juices and sports drinks: tritan material will not retain flavors or odors of liquid contents. Thermos will donate 3-percent of pink ribbon sales to support breast cancer initiatives. |
 |
Breast Cancer Awareness Ribbon Promise of a Cure Cuff Bracelet by Silver Insanity This Cuff Bracelet Will Fit up to a 8" Wrist and is 3/8" Wide Crafted of a Silver Toned Base Metal and Brought to High Polish Shine Set with a Bright Pink Breast Cancer Awareness Ribbon and Inscribed With The Phrase "Promise of a Cure" |
| © 2009 BrightSurf.com |