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Pediatric obesity may alter thyroid function and structure
December 03, 2008Chevy Chase, MD-In addition to its strong associations with hypertension, cardiovascular disease, and diabetes, pediatric obesity may induce alterations in thyroid function and structure, according to a new study accepted for publication in The Endocrine Society's Journal of Clinical Endocrinology & Metabolism (JCEM).
Thyroid hormones drive metabolism, however demonstration of a direct or strong correlation of obesity with deficient thyroid function has been controversial, and previous studies provide conflicting conclusions. While some studies have found that thyroid disorders may lead to obesity, this recent study shows that in some cases, it is the obesity that may cause the disorder.
"Our study shows that alterations in thyroid function and structure are common in obese children and we may have uncovered the link," said Giorgio Radetti, M.D., of the Regional Hospital of Bolzano in Italy and lead author of the study. "We found an association between body mass index and thyroid hormone levels which suggests that fat excess may have a role in thyroid tissue modification."
This study evaluated 186 overweight and obese children over a period of nearly three years. Researchers measured subjects' thyroid hormone levels and thyroid antibodies and also performed a thyroid ultrasound.
The presence of thyroid antibodies would suggest a diagnosis of Hashimoto's thyroiditis, an autoimmune disease of the thyroid where T-cells attack the cells of the thyroid. In this study, 73 children did not show these antibodies, yet their ultrasound pattern was still suggestive of Hashimoto's thyroiditis.
"The ultrasound findings are a bit mysterious," said Dr. Radetti. "However, the findings do suggest the existence of a low-grade inflammation state, which has been known to characterize obesity."
Thyroid function has been shown to return to normal after weight loss, said Dr Radetti, raising the question of the potential reversibility of thyroid abnormalities shown on an ultrasound. However, researchers still do not know whether the persistence of thyroid abnormalities in obese children may also progress into chronic thyroid disease in early adulthood. Dr. Radetti says more studies are needed to answer these questions.
The Endocrine Society
This study evaluated 186 overweight and obese children over a period of nearly three years. Researchers measured subjects' thyroid hormone levels and thyroid antibodies and also performed a thyroid ultrasound.
The presence of thyroid antibodies would suggest a diagnosis of Hashimoto's thyroiditis, an autoimmune disease of the thyroid where T-cells attack the cells of the thyroid. In this study, 73 children did not show these antibodies, yet their ultrasound pattern was still suggestive of Hashimoto's thyroiditis.
"The ultrasound findings are a bit mysterious," said Dr. Radetti. "However, the findings do suggest the existence of a low-grade inflammation state, which has been known to characterize obesity."
Thyroid function has been shown to return to normal after weight loss, said Dr Radetti, raising the question of the potential reversibility of thyroid abnormalities shown on an ultrasound. However, researchers still do not know whether the persistence of thyroid abnormalities in obese children may also progress into chronic thyroid disease in early adulthood. Dr. Radetti says more studies are needed to answer these questions.
The Endocrine Society
Thyroid Function Current Events and Thyroid Function News RSSNew genetic link between cardiac arrhythmias and thyroid dysfunction identified
Genes previously known to be essential to the coordinated, rhythmic electrical activity of cardiac muscle -- a healthy heartbeat -- have now also been found to play a key role in thyroid hormone (TH) biosynthesis, according to Weill Cornell Medical College researchers.
Concern over inappropriate diagnosis and treatment of thyroid problems
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Smoking during pregnancy may impair thyroid function of mom and fetus
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Thyrotropin levels associated with Alzheimer's disease risk in women
Women with low or high levels of the hormone thyrotropin, which affects thyroid gland function and thyroid hormone levels, appear to have a higher risk of developing Alzheimer's disease, according to a report in the July 28 issue of Archives of Internal Medicine, one of the JAMA/Archives journals.
Thyrotropin levels may be associated with coronary heart disease mortality in women
Women with increasing levels of thyrotropin within the normal range appear to have a higher risk of fatal coronary heart disease, according to a report in the April 28 issue of Archives of Internal Medicine, one of the JAMA/Archives journals.
Thyroid treatment no 'quick fix' for weight loss in children
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Fatigue - a common problem in patients who are recovering from leukaemia, lymphoma, myeloma and other haematological cancers - is associated with depression and reduced physical performance and not, as previously suggested, with anaemia, a flagging immune system or other physiological conditions. That is the conclusion of a German research team, reported today (Monday 19 July), in Annals of Oncology[1]. Cancer related fatigue - defined as an unusual and persistent sense of tiredness that can occur during or after treatment, may affect physical and mental ability and is not relieved by rest - is the most common and distressing problem for cancer patients after treatment. For many patients it
Poor prognosis for depression linked to an autoimmune thyroid condition?
Whether depression is linked to having an under-active thyroid gland has been debated for many years. Research published in BMC Psychiatry this week suggests that some patients with depression may be suffering from a subtle autoimmune thyroid condition, which could hinder their recovery. The study also suggests that physicians could use indicators of thyroid function to predict patients' responsiveness to antidepressants. As inpatients with depression often undergo routine thyroid tests, the data that physicians would need to create such a prediction are likely to be available to them already. Researchers from Greece studied 30 patients suffering from major depression, and 60 healthy people
To Benefit From Mushrooms
Mushrooms (of course, those grown in an ecologically safe area) accumulate many microelements good for human and animal health, in particular, selenium. The natural cycle of selenium was studied by a team from the Vernadsky Institute of Geochemistry and Analytical Chemistry in Moscow. The scientific expedition worked in the eastern part of the Meshchera (at the meeting point of the Moscow, Ryazan, and Vladimir areas). Scientists found selenium in many natural objects (soil, grass, leafs, elk`s excrements, mosquito larvae, and tissues of brown frog), however, its highest levels were observed in mushrooms. A concentration reached milligrams per
What Have Bats, Computer Science And Selenium Got In Common?
Bats, Computer Science and Selenium are three of the research areas to be covered by past and present fellows of the Daphne Jackson Trust in a symposium to celebrate its 10th Anniversary on Monday 21st January at the University of Surrey. There will be five presentations from Daphne Jackson Fellows who will talk about their research and the success of the Trust's work and what it has done for them. Dr Margaret Rayman from the University of Surrey is recognised as a world expert on selenium. She is Principal Investigator on the UK Pilot Study for the PRECISE Clinical Trial investigating the effect of selenium in cancer prevention. This is the pilot phase of a double-blind placebo-controlled
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