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Cytori reports benefit of adipose-derived regenerative cells in spinal disc model
December 08, 2008Cytori Therapeutics, Inc. (NASDAQ: CYTX) reported preclinical study results, which demonstrate the potential benefit of adipose-derived stem and regenerative cells (ADRCs) for the treatment of damaged intervertebral discs, evidenced by significantly increased disc tissue density and disc-specific extracellular matrix components at 12-months post treatment in a large animal model. The data were presented today at the 2008 Tissue Engineering and Regenerative Medicine International Society meeting.
This study demonstrates the potential of a patient's own ADRCs to repair the spinal disc. While this study relied upon the traditional glassware methodology for ADRC isolation, the Celution® System could increase the efficiency and cost-effectiveness of the procedure. The Celution® System is an automated, bedside device that isolates autologous ADRCs in a real-time fashion, thus representing a potential novel therapeutic for more than 300,000 patients undergoing spinal surgery annually.
In addition, in this preclinical study at 12 months post therapy, injured discs that were treated with ADRCs in HA showed significantly greater disc density. This finding is based on independent assessments of T2 weighted MRI, compared to injured discs that received no treatment.
As part of the study design, 12 large animals (6 for each time point), underwent injury of three lumbar discs. Six weeks following the injury, the three discs were randomly assigned to receive autologous ADRCs suspended in HA, HA only (control) or no treatment. The discs were then assessed at 6 and 12 months after treatment for matrix hydration and morphology, which both showed significant improvement in the ADRC treated discs. All ADRC treatments were well tolerated, evidenced by the lack of inflammation within the disc space. The reported results are a subset of top-line findings which will be reported in full in the Spring of 2009.
Cytori Therapeutics
Regenerative Cells Current Events and Regenerative Cells News RSSScientists discover clues to what makes human muscle age
A study led by researchers at the University of California, Berkeley, has identified critical biochemical pathways linked to the aging of human muscle. By manipulating these pathways, the researchers were able to turn back the clock on old human muscle, restoring its ability to repair and rebuild itself.
Limbs saved by menstrual blood stem cells
Cells obtained from menstrual blood, termed 'endometrial regenerative cells' (ERCs) are capable of restoring blood flow in an animal model of advanced peripheral artery disease.
Menstruation proves more than a curse
The cells which thicken the womb wall during a woman's menstrual cycle contain a newly discovered type of stem cell, and could be used in the treatment of damaged and/or old tissue.
Master regulatory gene of epithelial stem cells identified
The skin's ability to replace the tissue it sloughs off is controlled by a variety of genes. A new study from Harvard Medical School published in the May 4 issue of Cell, however, identifies a "master regulator" of this regeneration process not only for skin, but for many epithelial tissues including breast, prostate, and urogenital tract.
Selective marker found to indicate aggressive form of breast cancer
Researchers have linked a structural protein called nestin to a particularly deadly form of breast cancer, identifying a new biomarker that could lead to earlier detection and better treatment.
Joslin study refutes recent report that bone marrow can replenish female oocytes
Ovulated egg cells, or oocytes, in adult female mice are not formed from germ cells in the blood or bone marrow. That's the conclusion of a new study led by investigators at Joslin Diabetes Center and Harvard University.
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ABC News Nightline Stem Cell Breakthrough for Suffering Pets" Stem Cell Breakthrough for Suffering Pets: Stem cell therapy for humans has long been mired in ethical debates. But for animals, the therapy is already here. By injecting animals with their own adult stem cells, common pet maladies, like hip dysplasia and arthritis, can be improved 70 percent of the time. California's Vet-Stem laboratories has developed the groundbreaking procedure, harvesting the regenerative cells from the animals' fat deposits. Can the procedure one day be adapted for humans? Hillary Clinton: Sen. Hillary Clinton's surprise victory in New Hampshire last night was especially welcome at her campaign headquarters, a much-needed rebound after a third-place finish in last week's Iowa caucuses. Was her emotional moment before the primary the difference? Driving Smart: We... |
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