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Lean muscle mass helps even obese patients battle cancer
December 18, 2008Lean muscle-mass may give even obese people an advantage in battling cancer, a University of Alberta study shows.
The study, published in Lancet Oncology, provides evidence that varying body compositions of cancer patients likely plays a role in survival rates, activity levels during the illness and potentially, even the reaction to chemotherapy treatment.
Computed tomography images of 250 obese cancer patients were viewed in the study, and findings indicate that people with a condition called sarcopenic obesity-a depletion of lean muscle mass, paired with being severely overweight-lived an average of 10 months less than their counterparts who were obese, but who had more muscle mass.
They also tended to more often be bedridden and have worse physical function than people who did not have sarcopenic obesity.
"In many cases, people with sarcopenic obesity have as little or sometimes less muscle mass than thin people who look as of they were made of skin and bones," noted Vickie Baracos, a professor of oncology and adjunct professor of human nutrition at the University of Alberta, and lead author on the study.
The findings underscore the importance of including body composition when assessing patient prognosis, Baracos said. Factors like lean muscle-mass could even play a part in how these patients react to chemotherapy, and drug dosing could potentially be improved, she added. "It remains to be proven whether tailored doses of chemotherapy would improve treatment, but that's possible based on what we've seen in this study."
"With obesity reaching new levels, new concepts relating to body weight must be explored," Baracos said. "People's body compositions were less variable in the past and the condition of sarcopenic obesity is a recently recognized phenomenon."
University of Alberta
They also tended to more often be bedridden and have worse physical function than people who did not have sarcopenic obesity.
"In many cases, people with sarcopenic obesity have as little or sometimes less muscle mass than thin people who look as of they were made of skin and bones," noted Vickie Baracos, a professor of oncology and adjunct professor of human nutrition at the University of Alberta, and lead author on the study.
The findings underscore the importance of including body composition when assessing patient prognosis, Baracos said. Factors like lean muscle-mass could even play a part in how these patients react to chemotherapy, and drug dosing could potentially be improved, she added. "It remains to be proven whether tailored doses of chemotherapy would improve treatment, but that's possible based on what we've seen in this study."
"With obesity reaching new levels, new concepts relating to body weight must be explored," Baracos said. "People's body compositions were less variable in the past and the condition of sarcopenic obesity is a recently recognized phenomenon."
University of Alberta
Muscle Mass Current Events and Muscle Mass News RSSTreatment to improve degenerating muscle gains strength
A study appearing in Science Translational Medicine puts scientists one step closer to clinical trials to test a gene delivery strategy to improve muscle mass and function in patients with certain degenerative muscle disorders.
Scientists encouraged by new mouse model's similarities to human ALS
A new mouse model of amyotrophic lateral sclerosis (ALS) closely resembles humans with the paralyzing disorder, researchers at Washington University School of Medicine in St. Louis report.
Ethnic background may be associated with diabetes risk
Fat and muscle mass, as potentially determined by a person's ethnic background, may contribute to diabetes risk, according to a new study accepted for publication in The Endocrine Society's Journal of Clinical Endocrinology & Metabolism (JCEM).
Scientists discover clues to what makes human muscle age
A study led by researchers at the University of California, Berkeley, has identified critical biochemical pathways linked to the aging of human muscle. By manipulating these pathways, the researchers were able to turn back the clock on old human muscle, restoring its ability to repair and rebuild itself.
Nevada professor discovers new way to calculate body's 'Maximum Weight Limit'
Nevada professor discovers new way to calculate body's "Maximum Weight Limit" RENO, Nev. - Most of us are familiar with the term, Body Mass Index, or BMI, as an index to determine healthy body weight.
Large thighs protect against heart disease and early death
Men and women whose thighs are less than 60cm in circumference have a higher risk of premature death and heart disease, according to research published on bmj.com today.
Taking dex can improve high altitude exercise capacity in certain climbers
Taking dexamathasone prophlyactically may improve exercise capacity in some mountaineers, according to Swiss researchers. Dexamathasone, known popularly to climbers as "dex," has been used for years to treat altitude-related symptoms in mountaineers, but has never been tested for its ability to improve exercise capacity at high altitude.
Dysport proves safe, effective anti-wrinkle treatment, UT Southwestern plastic surgeons find
The new anti-wrinkle facial filler Dysport, which could be used as an alternative to Botox, noticeably reduced frown lines between the eyes, according to users and independent reviewers in a study involving plastic surgeons at UT Southwestern Medical Center.
Heart transplant recipients can improve fitness and perform high intensity workouts
Heart transplant recipients' cardio-respiratory fitness is around 30 to 50 per cent lower than age-matched healthy sedentary individuals.
Scripps research scientists observe human neurodegenerative disorder in fruit flies
A team of scientists from The Scripps Research Institute, Katholeike Universiteit Leuven, and the University of Antwerp, Belgium, among other institutions, has created a genetically modified fruit fly that mimics key features of Charcot-Marie-Tooth disease, a common neurodegenerative disorder that strikes about one out of every 2,500 people in the United States.
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