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Immune cells contribute to the development of Parkinson's disease
December 23, 2008Parkinson disease is a neurodegenerative disorder that impairs movement, balance, speech, and other functions. It is characterized by the loss of nerves in the brain that produce a substance known as dopamine.
Although the loss of dopamine-containing nerves is accompanied by accumulation of immune cells known as T cells, these accumulating T cells were not thought to have a role in the development of disease. However, Stéphane Hunot, Etienne C. Hirsch, and colleagues, at INSERM UMR 679, France, have now shown that CD4+ T cells make a significant contribution to the development of disease in a mouse model of Parkinson disease.
In the study, a substantial number of CD4+ T cells and CD8+ T cells were observed to have accumulated in postmortem brain tissue from individuals with Parkinson disease and mice with a Parkinson-like disease. Importantly, mice lacking all T cells developed substantially less severe disease in the mouse model of Parkinson disease. Further analysis indicated that protection was specifically associated with a lack of CD4+ T cells expressing the protein FasL. The authors therefore suggest that targeting the immune system might provide a new therapeutic approach to treating Parkinson disease. However, in an accompanying commentary, Stanley Appel, at Methodist Neurological Institute, Houston, warns that although these data provide rationale for immune-based strategies, there are a large number of questions that need to be answered before such approaches can be considered in the clinic.
Journal of Clinical Investigation
Journal of Clinical Investigation
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New Study Shows that Fetal Cells Transplanted into the Brain to Treat Parkinson's Disease May Not Function Long Term
Neurons grafted into the brain of a patient with Parkinson's disease fourteen years ago have developed Lewy body pathology, the defining pathology for the disease, according to research by Jeffrey H. Kordower, PhD, and associates and published in the April 6 issue of Nature Medicine.
Family study bolsters link between pesticides and Parkinson's
For the first time, the association between Parkinson's disease and exposure to pesticides has been shown in patients with the neurological disorder compared with their unaffected relatives, according to a study in the online open access journal BMC Neurology.
Practice parameters discuss treatment for narcolepsy, other hypersomnias of central origin
Practice parameters published in the December 1 issue of the journal SLEEP serve as both an update of previous practice parameters for the therapy of narcolepsy and as the first practice parameters to address treatment of other hypersomnias of central origin, including idiopathic hypersomnia, recurrent hypersomnia and hypersomnia due to medical condition.
PINK1 protects from Parkinson's
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Researchers identify protein pathway involved in Parkinson disease development
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Medical therapy for restless legs syndrome may trigger compulsive gambling
Compulsive gambling with extreme losses — in two cases, greater than $100,000 — by people without a prior history of gambling problems has been linked to a class of drugs commonly used to treat the neurological disorder restless legs syndrome (RLS).
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