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May hepatic granulomas be part of the histological spectrum of chronic hepatitis C?
December 29, 2008While older large series of patients with hepatic granulomas have found sarcoidosis and tuberculosis to be the most common causes of hepatic granulomas, recent works have noted some patients with chronic hepatic C and hepatic granulomas and no other obvious associations. Today, patients that undergo liver biopsy often have chronic hepatitis C that is being staged prior to possible anti viral therapy. The age of HIV and immunosuppression for organ transplants has also made opportunistic infections associated with hepatic granulomas more likely.
A research article to be published on November 7, 2008 in the World Journal of Gastroenterology addresses this question. The research team led by Ned Snyder from the University of Texas medical branch report a retrospective study of over 4 000 liver biopsies as well as a prospective study of 240 patients with chronic hepatitis C undergoing routine liver biopsies. They found that the most common association for hepatic granulomas was chronic hepatitis C. In the prospective study of patients with stable hepatitis C, almost 1% had hepatic granulomas.
In this paper, no reason for the association between granulomas and hepatitis C was found unless granuloma formation is part of the immune response to chronic hepatitis C. Hepatic granulomas have been associated with interferon therapy for hepatitis C and other disorders, but only one patient in the study had received interferon. Granulomas sometimes can develop in intravenous drug users from talc in the injection solution, but examination of the biopsies with polarized light revealed only one patient with crystalloid particles.
The authors concluded that granulomas are an uncommon part of the histologic spectrum of chronic hepatitis C. When granulomas are found in the liver of a patient with chronic hepatitis C, the clinician should be comfortable with the association after other pertinent diseases are excluded.
A reviewer felt this paper is a very good retrospective examination of characteristics associated with hepatogranulomas, with the added strength of the prospective surveillance.
World Journal of Gastroenterology
The authors concluded that granulomas are an uncommon part of the histologic spectrum of chronic hepatitis C. When granulomas are found in the liver of a patient with chronic hepatitis C, the clinician should be comfortable with the association after other pertinent diseases are excluded.
A reviewer felt this paper is a very good retrospective examination of characteristics associated with hepatogranulomas, with the added strength of the prospective surveillance.
World Journal of Gastroenterology
Granulomas Current Events and Granulomas News RSSNew beryllium reference material for occupational safety monitoring
Researchers at the National Institute of Standards and Technology (NIST), in collaboration with private industry and other government agencies, have produced a new reference material for beryllium.
TB -- hiding in plain sight
Current research suggests that Mycobacterium tuberculosis can evade the immune response.
MRI detects early heart damage in patients with sarcoidosis
To detect heart damage early in patients with the immune system disorder sarcoidosis, who are at elevated risk of dieing from heart problems, magnetic resonance imaging is twice as sensitive as conventional methods.
Researchers discover new disease-causing bacterium in patients with rare immune disorder
Scientists at the National Institute of Allergy and Infectious Diseases (NIAID), part of the National Institutes of Health (NIH), have discovered a new bacterium and determined that it can cause serious lymph node infections in patients with chronic granulomatous disease (CGD)-a rare immune disorder that leaves individuals susceptible to frequent and sometimes life-threatening fungal and bacterial infections.
Reconstruction of the lower jaw with a fibula autotrasplant
The University Hospital of the University of Navarra has carried out a complicated surgical operation on a child who had a particularly large benign tumour located in the mandibular region. The procedure involved the extraction of the lower jaw and its substitution by a bone transplant from the fibula of the patient.
Measuring Biodiversity and More: PLoS Biology Press Release
Biodiversity: measuring up to the loss Species are disappearing faster than biologists can identify and document them. Mindful of this crisis, nearly 200 countries (under the Convention on Biological Diversity) agreed to staunch the loss of biodiversity by 2010. However, to meet this goal, biologists need reliable metrics to monitor global trends in biodiversity. In the open access journal, PLoS Biology, Stuart Butchart from Birdlife International, Cambridge, UK, and others from Conservation International, IUCN and the Institute of Zoology, London, describe a new way to generate such an index that can measure trends in extinction risk for complete classes of organisms, starting with the wo
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Modern diagnosis and treatment of the minor venereal diseases;: The management of chancroid, granuloma inguinale, and lymphogranuloma venereum in general ... no. 223. American lectures in dermatology) by Orlando Canizares (Author) | |
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DR ROSE HEALING SALVE by DR. ROSE'S REMEDIES Dr. Rose's skin treatment is an all natural product that is anti-inflammatory, antiviral, antifungal, antiseptic and anti-scarring. It helps heal wounds, hot spots, allergies, burns, bruises, lacerations and insect bites. It promotes the healing of abscesses, speeds the healing of surgical wounds and cools and nourishes the skin. It also relieves itching, inflammation and irritation. Every one of the ingredients are 100 % natural. NO artificial colorings. No artificial preservatives. Steroid free. Gluten free |
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Granuloma Inguinal | |
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Granuloma Annulare - Herbal Treatment Pack by Oslo Health Solutions Granutab is a completely guaranteed and clinically proven herbal treatment for Granuloma Annulare . Its formulation consisting of purely natural ingredients based on the Unani (Greek) system of herbal medicine blended together in a specific proportion to fight and treat Granuloma Annulare effectively. |
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Granulomas - A Medical Dictionary, Bibliography, and Annotated Research Guide to Internet References by ICON Health Publications (Author) In March 2001, the National Institutes of Health issued the following warning: "The number of Web sites offering health-related resources grows every day. Many sites provide valuable information, while others may have information that is unreliable or misleading." Furthermore, because of the rapid increase in Internet-based information, many hours can be wasted searching, selecting, and printing.This book was created for medical professionals, students, and members of the general public who want to conduct medical research using the most advanced tools available and spending the least amount of time doing so. |
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Lick Granuloma Strips Small by Nurtured Pets Nurtured Pets now provides pet owners with a uniquely effective solution to deter licking and biting of hot spots and lick granulomas. Our Anti-Lick Strip is a great alternative to the deterrent sprays or the bulky E-collar (Elizabethean Collar). The Anti-Lick Strip is clinically proven to stop your pet from licking and/or biting: |
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Poststapedectomy reparative granuloma.(OTOSCOPIC CLINIC): An article from: Ear, Nose and Throat Journal by Willis S.S. Tsang (Author), John K.S. Woo (Author), Michael C.F. Tong (Author) This digital document is an article from Ear, Nose and Throat Journal, published by Thomson Gale on September 1, 2006. The length of the article is 428 words. The page length shown above is based on a typical 300-word page. The article is delivered in HTML format and is available in your Amazon.com Digital Locker immediately after purchase. You can view it with any web browser. Citation Details Title: Poststapedectomy reparative granuloma.(OTOSCOPIC CLINIC) Author: Willis S.S. Tsang Publication: Ear, Nose and Throat Journal (Magazine/Journal) Date: September 1, 2006 Publisher: Thomson Gale Volume: 85 Issue: 9 Page: 562(1) Distributed by Thomson... | |
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Successful treatment of disseminated granuloma annulare with adalimumab.(CASE REPORTS)(Case study)(Clinical report): An article from: Journal of Drugs in Dermatology by David Rosmarin (Author), Anne LaRaia (Author), Scott Schlauder (Author), Alice B. Gottlieb (Author) This digital document is an article from Journal of Drugs in Dermatology, published by Journal of Drugs in Dermatology, Inc. on February 1, 2009. The length of the article is 1967 words. The page length shown above is based on a typical 300-word page. The article is delivered in HTML format and is available immediately after purchase. You can view it with any web browser. Citation Details Title: Successful treatment of disseminated granuloma annulare with adalimumab.(CASE REPORTS)(Case study)(Clinical report) Author: David Rosmarin Publication: Journal of Drugs in Dermatology (Magazine/Journal) Date: February 1, 2009 Publisher: Journal of Drugs in Dermatology, Inc. Volume: 8 Issue: 2 Page: 169(3) Article Type: Clinical report, Case... | |
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Color aids in granuloma differential diagnoses: blue vs. red.(Clinical Rounds): An article from: Skin & Allergy News by Michele G. Sullivan (Author) This digital document is an article from Skin & Allergy News, published by International Medical News Group on December 1, 2003. The length of the article is 962 words. The page length shown above is based on a typical 300-word page. The article is delivered in HTML format and is available in your Amazon.com Digital Locker immediately after purchase. You can view it with any web browser. Citation Details Title: Color aids in granuloma differential diagnoses: blue vs. red.(Clinical Rounds) Author: Michele G. Sullivan Publication: Skin & Allergy News (Magazine/Journal) Date: December 1, 2003 Publisher: International Medical News Group Volume: 34 Issue: 12 Page: 30(1) Distributed by Thomson... | |
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Eosinophilic granuloma of the skin: response to intralesional corticosteroid injection.(CASE REPORTS)(Clinical report): An article from: Journal of Drugs in Dermatology by Elizabeth Myers (Author), Christopher R. Shea (Author), Thomas Krausz (Author), Vesna Petronic-Rosic (Author) This digital document is an article from Journal of Drugs in Dermatology, published by Thomson Gale on March 1, 2007. The length of the article is 2231 words. The page length shown above is based on a typical 300-word page. The article is delivered in HTML format and is available in your Amazon.com Digital Locker immediately after purchase. You can view it with any web browser. Citation Details Title: Eosinophilic granuloma of the skin: response to intralesional corticosteroid injection.(CASE REPORTS)(Clinical report) Author: Elizabeth Myers Publication: Journal of Drugs in Dermatology (Magazine/Journal) Date: March 1, 2007 Publisher: Thomson Gale Volume: 6 Issue: 3 Page: 329(4) Article Type: Clinical report Distributed by Thomson... |
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