Pneumococcal vaccine does not appear to protect against pneumoniaJanuary 06, 2009Commonly used pneumococcal polysaccharide vaccines do not appear to be effective for preventing pneumonia, found a study by a team of researchers from Switzerland and the United Kingdom http://www.cmaj.ca/press/pg48.pdf. In many industrialized countries, polysaccharide pneumococcal vaccines (PPVs) are currently recommended to help prevent pneumococcal disease in people aged 65 and over and for younger people with increased risk due to conditions like HIV. Studies have shown conflicting results regarding the efficacy of PPV. The study, a systematic review and meta-analysis, looked at 22 clinical trials, reviews and meta-analyses and more than 100,000 participants from countries in North America as well as India, Africa, Latin America and the Caribbean. Unlike other similar studies the authors examined the reasons why different clinical trials produced different results. They found that the quality of the studies substantially affected the results. When only high quality trials were included, there was no evidence that PPVs could prevent pneumonia. The study adds to the ongoing debate around effectiveness of the vaccine.
"Policy makers may therefore wish to reconsider their current recommendations for PPV, especially where routine pneumococcal conjugate immunization has been introduced," conclude Dr. Matthias Egger from the University of Bern, Switzerland and coauthors. However, in a related commentary http://www.cmaj.ca/press/pg18.pdf, Dr. Ross Andrews and coauthor from the Menzies School of Health Research, Darwin, Australia state that the researchers' conclusions exceed the evidence presented. They caution that there should be no change in vaccine policy in countries that recommend PPV to prevent invasive pneumococcal disease. Canadian Medical Association Journal Science News and Science Current Events Tag Cloud This tag cloud is a visual representation of term frequencies of random science news topics with common terms grouped together and emphasized by their display size. Cancer Patient Carbon Sequestration Autophagy Caesarean Section Arrhythmia Delirium Brachytherapy Nanotube Amphibians Psychotherapy Contact Lenses Biofilms Breastfeeding Micrornas Cardiac Surgery Wildfires Greenhouse Gas Sleep-disordered Breathing Ebola Memories Heart Attack Cyanobacteria Testosterone Kidney Cancer Calcium
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Related Pneumococcal Current Events and Pneumococcal News Articles Statins don't lower risk of pneumonia in elderly Taking popular cholesterol-lowering statin drugs, such as Lipitor® (atorvastatin), does not lower the risk of pneumonia. From poison to prevention One of the major challenges in modern vaccinology is to engineer vectors that are highly infectious, yet don't cause illness. Trickier still is to ensure that such weapons against infectious disease can be safely disarmed, once their immunogenic work is done. Mayo Clinic study finds increased risk of pneumococcal disease in asthma patients Mayo Clinic research shows adults with asthma are at increased risk of serious pneumococcal disease caused by Streptococcus pneumoniae, the most common bacteria causing middle ear infections and community acquired pneumonia. Governments urged to fight global child killer Pneumococcal disease, one of the world's leading causes of death and serious illness, must be recognised as an urgent global health issue together with HIV, malaria and TB, say the UK All-Party Parliamentary Group (APPG) on Pneumococcal Disease Prevention in the Developing World in a report launching at the House of Lords today. New insights could lead to a better pneumococcal vaccine Discovery of a new, previously unknown mechanism of immunity suggests that there may be a better way to protect vulnerable children and adults against Streptococcus pneumoniae (pneumococcal) infection, say researchers at Children's Hospital Boston and Harvard School of Public Health (HSPH). Flu shot does not reduce risk of death The widely-held perception that the influenza vaccination reduces overall mortality risk in the elderly does not withstand careful scrutiny, according to researchers in Alberta. Vaccinated infants well protected against severe pneumococcal infection in Norway Pneumococcus is a bacterium that can cause serious illnesses in some young children, e.g. meningitis, blood poisoning and pneumonia. Most of those who become ill are previously healthy without any known predisposing factors. The bacterium is present in the nose of up to 80 - 90% of healthy young children. Despite vaccine, public should not get complacent about pneumococcal disease Although the childhood pneumococcal conjugate vaccine has been a boon in reducing the incidence invasive pneumococcal disease (IPD), the public and the medical community must not get complacent, as non-vaccine strains, some resistant to antibiotics, are on the rise, say scientists at a meeting today in Boston. Tool creates personalized catch-up immunization schedules for missed childhood vaccinations A new downloadable software tool will help pediatricians, parents and other health care professionals determine how to adjust complex childhood immunization schedules when one or more vaccine doses aren't received at the proper time. Ashwell receptor reduces mortality during sepsis In research that solves the longest-standing mystery in glycobiology - a field that studies complex sugar chains called glycans - researchers at the University of California, San Diego School of Medicine have discovered that a molecule in the liver of all animals, called the Ashwell receptor, is critical in helping the body fight off the abnormal and lethal blood clotting caused by bacterial infection. More Pneumococcal Current Events and Pneumococcal News Articles |
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