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GEN reports on growing reliance on microfluidics technology
January 23, 2009Biotechnology companies are building on what they have learned about microfluidics techniques over the past decade and are expected to drive this market toward $1.9 billion in three years, reports Genetic Engineering and Biotechnology News (GEN); (www.genengnews.com). The technology offers a number of advantages, including reducing reagent consumption, increasing speed and analytical performance, multiparameter testing, and user friendliness, according to the January 15 issue of GEN.
"The globalization of life science research and an increasing trend toward novel diagnostic development, particularly point of care, are providing a significant boost toward a greater acceptance of microfluidics methodologies," says John Sterling, Editor in Chief of GEN.
Much of drug discovery focuses on finding inhibitors of enzyme targets such as kinases, phosphatases, and proteases. Caliper Life Sciences created its Mobility Shift Assay to interrogate druggable enzymes. It combines the advantages of capillary electrophoresis with microfluidics technology for the direct measurement of substrate and product.
Biosite has developed protein array technologies that contain microcapillaries for controlling the flow of fluids in immunoassay processes. The protein array format uses several different microcapillary designs to control the contact of sample with reagents and to direct the flow of fluid throughout the protein array. For example, after a blood sample is added to the array, a special internal filter separates cells from plasma. Next a capillary directs the sample into a chamber that contains dried immunoassay reagents. After an incubation time that is determined by another microcapillary element of the array, the sample next flows down a capillary path and interacts with an antibody array. The interactions are detected in the company's Triage® Meters that scan the array device with a laser diode.
Other companies covered in the GEN article include ChipShop, Genefluidics, Paraytec, CellASIC, and DiscoveRx.
Mary Ann Liebert, Inc./Genetic Engineering News
Biosite has developed protein array technologies that contain microcapillaries for controlling the flow of fluids in immunoassay processes. The protein array format uses several different microcapillary designs to control the contact of sample with reagents and to direct the flow of fluid throughout the protein array. For example, after a blood sample is added to the array, a special internal filter separates cells from plasma. Next a capillary directs the sample into a chamber that contains dried immunoassay reagents. After an incubation time that is determined by another microcapillary element of the array, the sample next flows down a capillary path and interacts with an antibody array. The interactions are detected in the company's Triage® Meters that scan the array device with a laser diode.
Other companies covered in the GEN article include ChipShop, Genefluidics, Paraytec, CellASIC, and DiscoveRx.
Mary Ann Liebert, Inc./Genetic Engineering News
Microfluidics Current Events and Microfluidics News RSSNew nanochemistry technique encases single molecules in microdroplets
Inventing a useful new tool for creating chemical reactions between single molecules, scientists at the National Institute of Standards and Technology (NIST) have employed microfluidics-the manipulation of fluids at the microscopic scale-to make microdroplets that contain single molecules of interest.
NIST calculations may improve temperature measures for microfluidics
If you wanted to know if your child had a fever or be certain that the roast in the oven was thoroughly cooked, you would, of course, use a thermometer that you trusted to give accurate readings at any temperature within its range.
New microchip technology performs 1,000 chemical reactions at once
Flasks, beakers and hot plates may soon be a thing of the past in chemistry labs. Instead of handling a few experiments on a bench top, scientists may simply pop a microchip into a computer and instantly run thousands of chemical reactions, with results - literally shrinking the lab down to the size of a thumbnail.
New lab-on-a-chip measures mechanics of bacteria colonies
Researchers at the University of Michigan have devised a microscale tool to help them understand the mechanical behavior of biofilms, slimy colonies of bacteria involved in most human infectious diseases.
A quicker, cheaper SARS virus detector -- one easily customizable for other targets
Members of a USC-led research team say they've made a big improvement in a new breed of electronic detectors for viruses and other biological materials - one that may be a valuable addition to the battle against epidemics.
NRL partners with industry to develop compact biosensor for wide-ranging applications
Scientists at the Naval Research Laboratory (NRL) are partnering with industry to develop a sensor system for biomolecules that could make a significant contribution to a variety of fields such as healthcare, veterinary diagnostics, food safety, environmental testing, and national security.
New holographic method could be used for lab-on-a-chip technologies
Researchers at Purdue University have developed a technique that uses a laser and holograms to precisely position numerous tiny particles within seconds, representing a potential new tool to analyze biological samples or create devices using nanoassembly.
Caltech bioengineers develop 'microscope on a chip'
Researchers at the California Institute of Technology have turned science fiction into reality with their development of a super-compact high-resolution microscope, small enough to fit on a finger tip.
Make your own microfluidic device with new kit from U-M
A type of device called a "lab-on-a-chip" could bring a new generation of instant home tests for illnesses, food contaminants and toxic gases. But today these portable, efficient tools are often stuck in the lab themselves. Specifically, in the labs of researchers who know how to make them from scratch.
Videos extract mechanical properties of liquid-gel interfaces
Blood coursing through vessels, lubricated cartilage sliding against joints, ink jets splashing on paper-living and nonliving things abound with fluids meeting solids.
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