Researchers identify a cell type that limits stroke damageJanuary 28, 2009A research team including Serge Rivest of University Laval's Faculty of Medicine has demonstrated the existence of a type of cells that limits brain damage after a stroke. The study was recently published in the online version of Nature Medicine. Laboratory experiments showed that three days after a stroke, the affected area of the brain is 20% larger in mice without regulatory T (Treg) cells than in normal mice. Effects on locomotor control are also more severe in mice lacking this type of cells. "These results lead us to believe that we could better preserve crucial functions like sight, speech, or control of the limbs if we rapidly stimulated the production of Treg cells in stroke victims," commented Professor Rivest. "We are particularly enthusiastic about this discovery because we already know what chemicals stimulate the production of Treg cells," continued the researcher. "So a treatment may be available in the not too distant future. We also believe that the protective effect of Treg cells could be used to treat other types of brain damage, especially that caused by head injury." Part of the brain damage occurring after a stroke is caused by the body's immune response. Cells such as microglia and lymphocytes provoke harmful effects similar to those observed during nervous system infections. When performing their cleaning functions, these cells also attack healthy cells, enlarging the damaged area of the brain and threatening certain brain functions. Researchers had suspected the existence of a mechanism that slows this harmful effect of immune cells in the brain, but no one had yet been able to demonstrate it. Treg cells, produced in the bone marrow and other organs of the immune system, migrate to the brain during the first few days after a stroke. They limit the extent of secondary damage by blocking the production of neurotoxins and modulating the action of lymphocytes and microglia in the brain. Université Laval |
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| Related Stroke Damage Current Events and Stroke Damage News Articles MIT: Muscle 'synergies' may be key to stroke treatment Researchers at MIT and San Camillo Hospital in Venice, Italy, have shown that motor impairments in stroke patients can be understood as impairments in specific combinations of muscle activity, known as synergies. Study: Added oxygen during stroke reduces brain tissue damage Scientists have countered findings of previous clinical trials by showing that giving supplemental oxygen to animals during a stroke can reduce damage to brain tissue surrounding the clot. Estrogen can reduce stroke damage by inactivating protein Estrogen can halt stroke damage by inactivating a tumor-suppressing protein known to prevent many cancers, Medical College of Georgia researchers say. Stem cells replace stroke-damaged tissue in rats Effective stem cell treatment for strokes has taken a significant step forward today (09 March) as scientists reveal how they have replaced stroke-damaged brain tissue in rats. Mesh-like Network of Arteries Adjusts to Restore Blood Flow to Stroke-Injured Brain A grid of small arteries at the surface of the brain redirects flow and widens at critical points to restore blood supply to tissue starved of nutrients and oxygen following a stroke, a study published this week has found. Brain implants may help stroke patients overcome partial paralysis Scientists have shown for the first time that neuroprosthetic brain implants may be able to help stroke patients with partial paralysis. Unusual case of a woman who suffered stroke during sex Minutes after having sexual intercourse with her boyfriend, a 35-year-old woman suddenly felt her left arm go weak. Her speech became slurred and she lost feeling on the left side of her face. New hope for stroke patients If a stroke patient doesn't get treatment within approximately the first three hours of symptoms, there's not much doctors can do to limit damage to the brain. Estrogen therapy helps or hurts the brain depending on reproductive status Estrogen therapy may limit stroke damage if started close to, but not long after reproductive cycles are over, according to a new animal study. The results were presented Sunday, June 15, at The Endocrine Society's 90th Annual Meeting in San Francisco. Old antibiotic may find new life as a stroke treatment Minocycline appears to reduce stroke damage in multiple ways - inhibiting white blood cells and enzymes that, at least acutely, can destroy brain tissue and blood vessels, respectively, says Dr. David Hess, chair of the Department of Neurology in the Medical College of Georgia School of Medicine. More Stroke Damage Current Events and Stroke Damage News Articles |
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