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Potential atherosclerosis drug exhibits no harmful side-effects in liver
February 13, 2009Appearing in the February issue of JLR
Researchers have developed and tested a synthetic atherosclerosis drug that can reduce the build-up of dangerous blood vessel plaques without producing the side-effect of fatty liver disease (which leads to its own set of problems like diabetes). The encouraging results of this study in mice could lead to a new type of drug to treat or even prevent atherosclerosis.
Targets of this drug, called DMHCA, are proteins called the Liver X Receptors (LXR). These proteins control a body's cholesterol levels by limiting the absorption of dietary cholesterol and by increasing the conversion of cholesterol into bile acids. Unfortunately, most LXR ligands also control fatty acid production, so therapeutic compounds that activate LXR also raise the levels of other fats, particularly in the liver.
DHMCA, though, had negligible effects of fat production in laboratory tests, so Dagmar Kratky and colleagues tested it in mice genetically engineered to be atherosclerotic. They found that compared to another experimental LXR drug (T0901317), DMHCA could significantly reduce the size of arterial lesions in the mice (45-48%) without increasing fat content in the liver or blood. Together, these results, appearing in the February Journal of Lipid Research, show much therapeutic promise.
American Society for Biochemistry and Molecular Biology
DHMCA, though, had negligible effects of fat production in laboratory tests, so Dagmar Kratky and colleagues tested it in mice genetically engineered to be atherosclerotic. They found that compared to another experimental LXR drug (T0901317), DMHCA could significantly reduce the size of arterial lesions in the mice (45-48%) without increasing fat content in the liver or blood. Together, these results, appearing in the February Journal of Lipid Research, show much therapeutic promise.
American Society for Biochemistry and Molecular Biology
Atherosclerosis Current Events and Atherosclerosis News RSSCan charcoal fight heart disease in kidney patients?
Charcoal may provide a new approach to managing the high rate of heart disease in patients with advanced kidney disease, according to preliminary research being presented at the American Society of Nephrology's 42nd Annual Meeting and Scientific Exposition in San Diego, CA.
Experts unveil new CVD guidelines and position papers
Several new guidelines and position papers offering the most up to date information to ensure that clinicians practice evidence-based medicine were released at the Canadian Cardiovascular Congress 2009 this week.
Canadian scientists link fat hormone to death from potentially deadly blood infection
A new Canadian study has found that lower-than-normal levels of a naturally-occurring fat hormone may increase the risk of death from sepsis-an overwhelming infection of the blood which claims thousands of lives each year.
Healthy neighborhoods may be associated with lower diabetes risk
Individuals living in neighborhoods conducive to physical activity and providing access to healthy foods may have a lower risk of developing type 2 diabetes in a five-year period, according to a report in the October 12 issue of Archives of Internal Medicine, one of the JAMA/Archives journals.
Liver cells grown from patients' skin cells
Scientists at The Medical College of Wisconsin in Milwaukee have successfully produced liver cells from patients' skin cells opening the possibility of treating a wide range of diseases that affect liver function.
National report shines light on lupus 50-year treatment drought
Today, The Lewin Group, a national health care consulting firm, issued recommendations on ways to overcome the barriers that have obstructed lupus drug development resulting in no new drug approval for this disease in more than 50 years - since the Eisenhower Administration.
Calcium scans may be effective screening tool for heart disease
A simple, non-invasive test appears to be an effective screening tool for identifying patients with silent heart disease who are at risk for a heart attack or sudden death.
Despite size, NFL players not more likely to develop heart disease, even after retirement
Former professional football players with large bodies don't appear to have the same risk factors for heart disease as their non-athletic counterparts, UT Southwestern Medical Center researchers have found in studying a group of National Football League (NFL) alumni.
Viagra relatives may shrink abnormally large hearts
Compounds related to Viagra, which is already in clinical trials to prevent heart failure, may also counter the disease in a different way, according to a study published online today in the journal Circulation Research.
Coronary imaging techniques helps to identify plaques likely to cause heart attacks
Late-breaking results from the PROSPECT clinical trial shed new light on the types of vulnerable plaque that are most likely to cause sudden, unexpected adverse cardiac events, and on the ability to identify them through imaging techniques before they occur.
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Dyslipidemia and Atherosclerosis Essentials 2009 by Christie M. Ballantyne (Author), James H. O'Keefe (Author), Antonio M. Gotto (Author) The World's Leading Experts Provide all the 'Essentials' Needed to Manage Patients in the Office, on the Ward, and in the Intensive Care Unit! Written by key opinion leaders in the field of cardiology, Dyslipidemia Essentials integrates the latest clinical guidelines and trials into a practical step-by-step guide to the management of dyslipidemia. Important clinical trials, common management pitfalls, and other cardiovascular risk reduction measures are also emphasized. Topics include: Step-by-step guide to intensive LDL lowering; NCEP ATP III and AHA/ACC guideline Updates; Treatment of low HDL cholesterol and elevated triglyceride; 73 dyslipidemia trials and 17 drug summaries |
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Journal of Atherosclerosis and Thrombosis by Japan Publications Trading Co | |
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Glucose-Balance - Sale! Dr. Kang's formula for use in treating diabetes mellitus and prevents damage of heart;liver;kidney and atherosclerosis from diabetes. Limited time offer. by Trilight,Inc. From the Western scientific perspective, diabetes mellitus is an inherited endocrine disorder characterized by a variable degree of carbohydrate intolerance and specific vascular lesions (i.e., thickening of the capillary basement membrane.) The endocrine aspect of this disease is the lack of sufficient pancreatic insulin to take up nutrients from the blood, in particular, glucose. The short term danger would then be a sort of tissue starvation leading to rapid fat metabolism leading to ketoacidosis and ultimately to metabolic acidosis, shock and death. The long term dangers involve vascular lesions beginning in the lower extremities and fundus of the eye leading to tissue death, loss of sight and limb amputation. In the short term, immediate symptoms include thirst, hunger and frequent... |
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Biochemistry of Atherosclerosis (Advances in Biochemistry in Health and Disease) by Sukhinder C. Kaur (Editor) At its present rate of growth, atherosclerosis will be the major cause of death from disease by the year 2020. Atherosclerosis is an extremely complex, biochemical, multifactorial process. This book will cover many aspects of atherogenesis, with particular emphasis on lipid and lipoprotein metabolism. We will cover all aspects of the regulation of cholesterol homeostasis and the importance of each pathway. This book will explore the role of nuclear hormone receptors on lipid and lipoprotein metabolism and their complex roles in atherogenesis. Finally, how the use of genetic studies can help sort out the immense complexities that mediate these aspects of atherogenesis will be discussed. |
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Transeophageal Echo Aorta with Heavy Atherosclerosis Photographic Poster Print, 16x12 by Art.com Art.com is the world's largest retailer of art prints, posters, photographs, and framed artwork. With our huge selection of over 400,000 prints, you'll easily find the perfect piece for your home, office, or classroom. Our art is printed on quality paper. When you order framed artwork, the piece is built by our team of in-house professionals. Visit our Amazon store today at www.amazon.com/artdotcom to find Special Offers and search for products based on 'Artist Name' and 'Subject Categories' such as Movie, Music, Vintage, TV, Children, Travel, Kitchen, Museum Art, Animals, Floral, Motivational, and Sports. Art.com is dedicated to providing you with high quality products and service by offering you 100% satisfaction guaranteed. We ship internationally to over 80 countries. Decorate your... |
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TwinPeak Organic Green Tea - 50 Individually Wrapped Tea Bags (3.5 Oz) by FooJoy Our Organic tea comes from mountain top gardens tended by traditional methods. These selected special pristine tea gardens where no preservatives or chemicals are used. In these tea gardens master planters nurture tea bushes with natural organic biomass and loving care. Only these tea gardens are used for Twinpeak tea. Organic oolong tea is a semi-fermented variety, representing a mid-range of the qualities of black and green teas and displaying a certain balance and harmony. Oolong tea is delightfully aromatic and a very appropriated healthiest beverages. Twinpeak tea will provid you with the finest tea. This tea packed in unbleached tea bag paper gives a good healthy drinking enjoyment |
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Women, Stroke and the Red Dress: Cerebrovascular Disease in Women In most age groups, more men than women will have a stroke in a given year. However, more than half of total stroke deaths occur in women. At all ages, more women than men die of stroke. This talk will discuss the reasons for these disparities throughout a women's lifetime. |
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Taurine 500mg With B6 - 100 - Tablet by Country Life TAURINE 500 mg w/B-6 Free Form Amino Acid Supplement with B-6 Hypoallergenic/Kosher A non-essential amino acid that aids in fat metabolism. B-6 aids in the utilization of Taurine.** Directions: Adults take one (1) to two (2) tablets daily, preferably between meals. Other Ingredients: Cellulose, stearic acid, magnesium stearate, silica, cellulose & glycerin coating. No: Yeast, corn, wheat, soy, gluten, milk, salt, sugar, starch, preservatives or artificial color. ... |
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Domyaku Koka = Journal of Japan Atherosclerosis Society by Japan Publications Trading Co | |
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Unclog Your Arteries : How I Beat Atherosclerosis by Gene McDougall (Author) Heart attack or bypass surgery? - or even if not- if you are overweight, have high blood pressure, high blood sugar, diabetes, high cholesterol, heart disease, or a family history of any, read this and then keep it for reference. |
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