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Targeting the protein AEG1 impairs human liver cancer growth in mice
February 17, 2009Hepatocellular carcinoma (HCC) is a highly aggressive form of liver cancer and one of the 5 most common cancers worldwide. Devanand Sarkar and colleagues, at Virginia Commonwealth University School of Medicine, Richmond, have now identified a gene that is expressed at high levels in human HCC tumor samples and generates a protein important for HCC progression. They therefore suggest that targeting this gene (AEG1), or the protein that it generates, might provide a new therapeutic strategy for the treatment of HCC.
In the study, human liver cells were found to express only low levels of the protein AEG1, whereas human HCC tumor samples expressed very high levels. This was associated with an increase in the number of copies of the AEG1 gene in human HCC tumor samples. Functionally, human liver cell lines engineered to overexpress AEG1 grew faster than nonengineered cells and developed into highly aggressive tumors when transplanted into mice. In addition, knocking down levels of AEG1 in human HCC cell lines after they had been allowed to form a tumor in mice limited further growth. Further analysis revealed that the effects of AEG1 were mediated, in part, via its ability to activate the Wnt signaling pathway.
Journal of Clinical Investigation
Promising novel treatment for human cancer -- Chrysanthemum indicum extract
A series of studies have demonstrated that Chrysanthemum indicum possesses antimicrobial, antiinflammatory, immunomodulatory, and neuroprotective effects.
A new therapeutic option for human hepatocyte cancer
p53-impaired tumors may be particularly suitable to parvovirus H-1-induced therapy. Although the p53 deficiency in tumors may induce resistance to chemotherapeutic agents, this will not affect the tumor cell susceptibility to H-1 PV-induced oncolytic infections.
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Human-Centric Computing Languages and Environments (Hcc 2002), 2002 IEEE Computer Society International Symposium on (Formerly Visual Languages (Vl by IEEE Computer Society (Author) This text contains information on computer engineering as presented as the 2002 IEEE Computer Society International Symposium on (formerly visual languages VL) Human-Centric Computing Languages and Environments (HCC 2002). | |
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2007 IEEE Symposium on Visual Languages and Human-centric Computing (Vl/hcc 2007) by Institute of Electrical and Electronics Engineers (Compiler), P. Cox (Compiler) | |
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2006 IEEE Symposium on Visual Languages and Human-centric Computing (Vl/hcc 2006) by Institute of Electrical and Electronics Engineers (Compiler) | |
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Short description of the research group on knowledge-based systems (KBS) and human-computer communication (HCC) (Technical report. University of Colorado, Boulder. Dept. of Computer Science) by Gerhard Fischer (Author) | |
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HCC board approves pay hike.(Strictly Business)(Hinds Community College): An article from: Mississippi Business Journal by Wally Northway (Author) This digital document is an article from Mississippi Business Journal, published by Venture Publications on January 3, 2005. The length of the article is 395 words. The page length shown above is based on a typical 300-word page. The article is delivered in HTML format and is available in your Amazon.com Digital Locker immediately after purchase. You can view it with any web browser. Citation Details Title: HCC board approves pay hike.(Strictly Business)(Hinds Community College) Author: Wally Northway Publication: Mississippi Business Journal (Magazine/Journal) Date: January 3, 2005 Publisher: Venture Publications Volume: 27 Issue: 1 Page: 9(1) Distributed by Thomson... | |
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Drugs & Human Behavior by David M. Grilly (Author) This text provides a general overview of the field of psychopharmacology and is most appropriate for second to third year level undergraduate students. It assumes no previous knowledge of biology or chemistry and includes definitions of technical jargon. The book covers commonly used psychoactive drugs; general factors of drug action in the nervous system; common properties of recreational/social drugs; and the theoretics of using drugs for treatment of mental and behavioural dysfuntion. It provides a balanced treatment of behavioural and psychological issues. |
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