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LSUHSC research may benefit diabetes by increasing understanding of how to control islet cell growth
February 18, 2009New Orleans, LA - Michael Lan, PhD, Professor of Pediatrics and Genetics at LSU Health Sciences Center New Orleans, is the senior author of a paper revealing the molecular mechanism of how a protein determines the fate of the cells that make and release insulin. Zinc Finger Transcription Factor INSM1 Interrupts Cyclin D1 and CDK4 Binding and Induces Cell Cycle Arrest, a paper in press currently available online, will be published in the Journal of Biological Chemistry, Vol. 284, Issue 9, 5574-5581, February 27, 2009.
Dr. Lan's laboratory is studying INSM1, a protein involved in the regulation of hormone- producing, or endocrine, cells. INSM1 plays a critically important role in the development of pancreatic beta cells- the only cells in the body that secrete insulin. Beta cells are located in islet cell clusters throughout the pancreas. Diabetes mellitus type 1 results from the destruction or dysfunction of islets and their beta cells. Type 2 diabetes results from the body's inability to use insulin properly and a gradual decrease in the pancreas's ability to make it.
In this study, the research group used pancreatic cancer cells to investigate the effects of INSM1 on cell cycle function. INSM1 is a transcription factor- a protein that binds to specific sequences of DNA and controls the target gene expression or action. The researchers developed an inducible system to "turn on" INSM1 in pancreatic cancer cells and found that it resulted in a significant reduction in the cells' growth rate. They showed that the mechanism for this growth inhibition was due to an interaction between INSM1 and cyclin D1, an important cell growth promoting protein. Through the interaction between these two proteins, the growth of the tumor cells was impaired. Further, transplantation of these INSM1 on pancreatic tumor cells into mice showed the growth rate of these tumor cells was significantly inhibited compared to the control cells.
"Taken together, we provide evidence to support that INSM1 binds to cyclin D1, a critical factor in cell growth, and interrupts normal cellular proliferation," notes Dr. Lan. "Our study furthers our understanding of how to control islet cell growth in the culture system, which may ultimately benefit diabetes."
Louisiana State University Health Sciences Center
"Taken together, we provide evidence to support that INSM1 binds to cyclin D1, a critical factor in cell growth, and interrupts normal cellular proliferation," notes Dr. Lan. "Our study furthers our understanding of how to control islet cell growth in the culture system, which may ultimately benefit diabetes."
Louisiana State University Health Sciences Center
Diabetes Current Events and Diabetes News RSSESC to give talks on Diabetes in three cities in China
As a result of successful events organised last year, a second Joint Scientific Forum, organised by the European Society of Cardiology (ESC) and the European Association for the Study of Diabetes (EASD), two of the most respected professional medical organisations in Europe, will be held from 27-29 November at three venues across China - Beijing, Shanghai and Guangzhou.
New research shows versatility of amniotic fluid stem cells
For the first time, scientists have demonstrated that stem cells found in amniotic fluid meet an important test of potential to become specialized cell types, which suggests they may be useful for treating a wider array of diseases and conditions than scientists originally thought.
First reconstitution of an epidermis from human embryonic stem cells
Stem cell research is making great strides. This is yet again illustrated by a study carried out by the I-STEM* Institute (I-STEM/ Inserm UEVE U861/AFM), published in the Lancet on 21 November 2009. The I-STEM team, directed by Marc Peschanski has just succeeded in recreating a whole epidermis from human embryonic stem cells.
An atomic-level look at an HIV accomplice
Since the discovery in 2007 that a component of human semen called SEVI boosts infectivity of the virus that causes AIDS, researchers have been trying to learn more about SEVI and how it works, in hopes of thwarting its infection-promoting activity.
Scripps research scientists find new link between insulin and core body temperature
A team led by scientists at The Scripps Research Institute have discovered a direct link between insulin-a hormone long associated with metabolism and metabolic disorders such as diabetes-and core body temperature.
Scientists find molecular trigger that helps prevent aging and disease
Researchers at Mount Sinai School of Medicine set out to address a question that has been challenging scientists for years: How do dietary restriction-and the reverse, overconsumption-produce protective effects against aging and disease?
Pivotal study for PSD502 -- the first potential treatment for premature ejaculation
At the annual meeting of the Sexual Medicine Society of North America (SMSNA), Inc. in San Diego, Sciele Pharma, Inc., a Shionogi Company and Plethora Solutions Limited, a wholly owned subsidiary of Plethora Solutions Holdings PLC ("Plethora" - AIM:PLE)., today presented data from its second positive pivotal study of PSD502 for the treatment of premature ejaculation (PE).
Night Beat, Overtime and a Disrupted Sleep Pattern Can Harm Officers' Health
A police officer who works the night shift, typically from 8 p.m. to 4 a.m., already is at a disadvantage when it comes to getting a good "night's" sleep.
Fat collections linked to decreased heart function
Researchers from Boston University School of Medicine (BUSM) have shown that fat collection in different body locations, such as around the heart and the aorta and within the liver, are associated with certain decreased heart functions.
Thoughtful words help couples stay fighting fit
Couples who bring thoughtful words to a fight release lower amounts of stress-related proteins, suggesting that rational communication between partners can ease the impact of marital conflict on the immune system.
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