 |
|
What is the most effective therapy for low-dose aspirin induced peptic ulcer?
February 19, 2009The incidence of low-dose aspirin-induced peptic ulcer seems to be increasing in Japan in conjunction with the increasing proportion of elderly individuals, in whom metabolic syndrome frequently develops. However, a therapeutic and prevention strategy for such peptic ulcers has not yet been established.
A research team led by Dr. Satoshi Mochida from Japan addressed this question. Their study will be published on February 14, 2009 in the World Journal of Gastroenterology.
In their study, Upper gastrointestinal endoscopy was performed in 68 patients receiving daily low-dose aspirin (81 or 100 mg/day). The endoscopic findings were classified according to the Lanza score, and the scores were compared between groups categorized according to the concomitant use of anti-ulcer drugs and the types of drugs used. In another study, 31 hemorrhagic peptic ulcer patients who had been receiving low-dose aspirin were enrolled. The patients were randomly classified into the proton pump inhibitor (PPI)-treated group and the H2 receptor antagonist (H2RA)-treated group. The administration of low-dose aspirin was continued concomitantly, and endoscopic examinations were performed 8 wk later.
They found that the Lanza scores (mean ± SD) of the gastro-mucosal lesions were 1.0 ± 1.9 and 1.9 ± 2.3 in 8 and 16 patients receiving prevention therapy with a PPI and an H2RA, respectively. Both scores were significantly smaller than the scores in 34 patients who were not receiving prevention therapy (4.7 ± 1.0) and in 10 patients receiving cytoprotective anti-ulcer drugs (4.3 ± 1.6). In the prospective study, 18 and 13 patients received a PPI and an H2RA, respectively. Endoscopic examinations revealed that the tissue in the region of the gastro-mucosal lesions had reverted to normal in all patients in the PPI-treated group and in 12 patients (92%) in the H2RA-treated group; no significant differences were observed between the groups.
Their results indicated that H2RA therapy was effective for both the prevention and treatment of low-dose aspirin induced peptic ulcers, similar to the effects of PPIs, while cytoprotective anti-ulcer drugs were ineffective in preventing peptic ulcers.
World Journal of Gastroenterology
They found that the Lanza scores (mean ± SD) of the gastro-mucosal lesions were 1.0 ± 1.9 and 1.9 ± 2.3 in 8 and 16 patients receiving prevention therapy with a PPI and an H2RA, respectively. Both scores were significantly smaller than the scores in 34 patients who were not receiving prevention therapy (4.7 ± 1.0) and in 10 patients receiving cytoprotective anti-ulcer drugs (4.3 ± 1.6). In the prospective study, 18 and 13 patients received a PPI and an H2RA, respectively. Endoscopic examinations revealed that the tissue in the region of the gastro-mucosal lesions had reverted to normal in all patients in the PPI-treated group and in 12 patients (92%) in the H2RA-treated group; no significant differences were observed between the groups.
Their results indicated that H2RA therapy was effective for both the prevention and treatment of low-dose aspirin induced peptic ulcers, similar to the effects of PPIs, while cytoprotective anti-ulcer drugs were ineffective in preventing peptic ulcers.
World Journal of Gastroenterology
Low-dose Aspirin Current Events and Low-dose Aspirin News RSSAspirin recommendation underscores need for physicians and patients to discuss benefits and risk
The President of the American College of Preventive Medicine commended the U.S. Preventive Services Task Force (USPSTF) today for its recommendations on aspirin use for primary prevention of heart attack and stroke, released in the March 17 issue of the Annals of Internal Medicine, citing its improved specificity over previous guidelines.
Low-dose aspirin does not appear to reduce risk of CV events in patients with diabetes
Low-dose aspirin as primary prevention did not appear to significantly reduce the risk of a combined end point of coronary, cerebrovascular and peripheral vascular events in patients with type 2 diabetes, according to a new study in JAMA.
Aspirin, acid blocker a-day keeps GI bleeding
For patients with clogged heart arteries who take long-term, low-dose aspirin to prevent a cardiac event, adding a stomach acid-blocking drug to their daily routine has been shown to reduce their risk for upper gastrointestinal bleeding - an infrequent, but serious side-effect of regular aspirin use.
Many Stroke, Heart Attack Patients May Not Benefit from Aspirin
Up to 20 percent of patients taking aspirin to lower the risk of suffering a second cerebrovascular event do not have an antiplatelet response from aspirin, the effect thought to produce the protective effect, researchers at the University at Buffalo have shown.
Ultra-low-dose aspirin might decrease bleeding severity in portal hypertension
In rats with portal hypertension, ultra-low-dose aspirin has shown a normalizing effect of platelet-endothelial cell alterations and bleeding time. Further, this effect is mediated by Cyclooxygenase 2 inhibition.
Ibuprofen puts high risk cardiac patients at risk
Doctors who treat the painful condition of osteoarthritis in patients with increased cardiovascular risk need to be cautious. A team lead by researchers at Mount Sinai School of Medicine, are the first to study outcomes in high cardiovascular risk patients with osteoarthritis.
Low-dose aspirin offers lower chance of asthma
In a large, randomized, placebo-controlled study of 22,071 healthy male physicians, taking a low-dose of aspirin every other day lowered the risk of receiving an initial asthma diagnosis by 22 percent.
Low-dose aspirin reduces cardiovascular events
Taking low-dose aspirin daily reduces the risk of heart attack and stroke, as well as the risk of dying, among patients who previously have had a heart attack or stroke but whose cardiovascular disease has stabilized.
Nonsteroidal anti-inflammatory drugs use associated with higher gastrointestinal complications
Nonsteroidal anti-inflammatory drugs (NSAIDs) provide a broad range of benefits for patients who require their use, but health care providers need to carefully consider the associated risks before prescribing these drugs for their patients, according to a multi-disciplinary panel of experts convened by the AGA Institute.
Risks of gastrointestinal ulcers linked to aspirin use might outweigh its benefits for the heart
Doctors should consider whether patients are at high risk of stomach ulcers before prescribing aspirin treatment.
More Low-dose Aspirin Current Events and Low-dose Aspirin News Articles
 |
Member's Mark - Aspirin 81 mg, Adult Low Strength, 500 Tablets, Compare to St. Joseph's by Sam's West, Inc. 500 tablets |
 |
Bayer Low Dose 81 mg Aspirin Regimen-400 Tablets by Bayer Safety Coated "Baby" Aspirin - Aspirin Regimen For Adult Use * Often Recommended as "Baby" Aspirin by Doctors for Adult Aspirin Regimen Use * Small, Easy-To-Swallow Tablets * Safety Coated for Added Stomach Protection * Aspiring Protects Your Heart by Keeping Your Blood Flowing Freely For the temporary relief of minor aches and pains or as recommended by your doctor. Because of its delayed action, this product will not provide fast relief of headaches or other symptoms needing immediate relief. Ask your doctor about other uses for Safety Coated 81 mg Aspirin. |
 |
Low Dose Aspirin (enteric coated) 81mg 500 Tablets by Life Extension Numerous studies document the multiple health benefits of daily low dose aspirin. Aspirin helps to maintain normal platelet aggregation in blood vessels and the production of prostaglandin E2 and possibly C-reactive protein. |
 |
KS Enteric Coated Aspirin 81 mg Tablets - Adult Low Strength Regimen - Compare to the Active Ingredients in Bayer Enteric Coated Low Strength Aspirin - 730 ct. by Kirkland Signature Read all instructions and warnings before taking this or any other medication. |
 |
Bayer Aspirin Pain Reliever/ Fever Reducer, Low Dose Safety Coated for Baby (81 mg), 200-Count Enteric Coated Tablets (Pack of 2) by Bayer It is most often used by patients who are taking aspirin on a regular basis under a doctor's supervision. This product contains one-quarter the medicine of a regular strength aspirin tablet allowing you to more conveniently take the dosage directed by you |
 |
Bayer Low Dose Aspirin Plus Cholesterol Lowering Phytosterols -120 Duo-Caps by Bayer If you are on a cholesterol-lowering medication, be sure to ask your doctor if Bayer Aspirin with Heart Advantage is right for you. Aspirin is not appropriate for everyone, so be sure to talk to your doctor before you begin an aspirin regimen. *Dietary supplements or food containing at least 400 mg per serving of free phytosterols eaten twice a day with meals for a daily total intake of at least 800 mg, as part of a diet low in saturated fat and cholesterol, may reduce the risk of heart disease by lowering blood cholesterol. Each Bayer Aspirin with Heart Advantage Duo-Cap contains 400 mg of free phytosterols. This product is not a replacement for cholesterol-lowering medications. Aspirin Drug Facts: Uses: * For the temporary relief of minor aches and pains or as recommended by your... |
 |
Kirkland Low Dose Aspirin (81mg x 2 x 365 enteric coated tablets) by Kirkland Aspirin Regimen. Pain Reliever. |
 |
Aspirin Enteric Coated Tablets, Low Strength 81Mg - 1000 Tablets by Aspirin Delayed Release Tablets |
|
Low-dose aspirin a risk factor for GI bleeding: physicians' health study data.(gastrointestinal): An article from: Internal Medicine News by Sharon Worcester (Author) This digital document is an article from Internal Medicine News, published by International Medical News Group on August 15, 2003. The length of the article is 605 words. The page length shown above is based on a typical 300-word page. The article is delivered in HTML format and is available in your Amazon.com Digital Locker immediately after purchase. You can view it with any web browser. Citation Details Title: Low-dose aspirin a risk factor for GI bleeding: physicians' health study data.(gastrointestinal) Author: Sharon Worcester Publication: Internal Medicine News (Magazine/Journal) Date: August 15, 2003 Publisher: International Medical News Group Volume: 36 Issue: 16 Page: 16(1) Distributed by Thomson... | |
 |
Bayer Low Dose Aspirin Regimen - 400ct by Bayer Overview Bayer pain reliever protects your heart by keeping your blood flowing freely. Safety coated for added stomach protection. Recommended by doctors for aspirin regimen use. SpecificationsProtects your heart by keeping your blood flowing freely Safety coated for added stomach protection Recommended by doctors for aspirin regimen use Low dose 400 tablets Delayed release aspirin tablets 81mg Enteric Pain reliever |
| © 2009 BrightSurf.com |