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A useful method to diagnose chest pain with foregut symptoms
February 19, 2009Recent reports have indicated that recurrent chest pain is often a result of esophageal motility disorders or gastroesophageal reflux diseases (GERD), which is known as esophageal chest pain. However, very few studies have been performed about esophageal manometric studies, 24-h intra-esophageal pH monitoring and a Holter electrocardiography for the differential diagnosis of chest pain caused by esophageal dysfunctional and/or myocardial ischemia.
A research team led by Prof. Ru Wen Wang from China addressed this question. Their study will be published on February 14, 2009 in the World Journal of Gastroenterology.
In their study, 61 patients with chest pain and foregut symptoms were included. Thirty-nine patients were diagnosed with non-specific esophageal motility disorders (29 patients with abnormal gastroesophageal reflux and eight patients with myocardial ischemia). Five patients had diffuse spasm of the esophagus plus abnormal gastroesophageal reflux (two patients had concomitant myocardial ischemia), and one patient was diagnosed with nutcracker esophagus.
The study indicated that spasm of the esophageal smooth muscle might cross talk with the heart-coronary smooth muscle, leading to myocardial ischemia. And the combination of esophageal manometric studies, 24-hour intraesophageal pH monitoring and Holter electrocardiography are significant for the differential diagnosis of chest pain, particularly with foregut symptoms. As an added incentive, combined monitoring is very cost-effective to the patients from developing country.
World Journal of Gastroenterology
The study indicated that spasm of the esophageal smooth muscle might cross talk with the heart-coronary smooth muscle, leading to myocardial ischemia. And the combination of esophageal manometric studies, 24-hour intraesophageal pH monitoring and Holter electrocardiography are significant for the differential diagnosis of chest pain, particularly with foregut symptoms. As an added incentive, combined monitoring is very cost-effective to the patients from developing country.
World Journal of Gastroenterology
Gastroesophageal Reflux Current Events and Gastroesophageal Reflux News RSSReflux esophagitis due to immune reaction, not acute acid burn, UT Southwestern researchers report
Contrary to current thinking, a condition called gastroesophageal reflux disease (GERD) might not develop as a direct result of acidic digestive juices burning the esophagus, UT Southwestern Medical Center researchers have found in an animal study.
Commentary warns of unexpected consequences of proton pump inhibitor use in reflux disease
Despite being highly effective and beneficial for many patients, unexpected consequences are emerging in patients who are prescribed proton pump inhibitors (PPIs) for reflux diseases.
Barrett's esophagus patients have same survival rates as general population
New Mayo Clinic research has found that survival rates of patients with Barrett's esophagus, which can be a precursor for esophageal cancer, are no different than the survival rates for the general population.
GERD negatively impacts sleep quality, results in considerable economic burden
There has been much debate about the relationship between gastroesophageal reflux disease (GERD) and sleep.
GERD patient satisfaction hinges on medication type and physician bedside manner
Patient satisfaction with their medications and the quality of interactions with their doctor reflect the success of gastroesophageal reflux disease (GERD) therapy, according to a new study in Clinical Gastroenterology and Hepatology, the official journal of the American Gastroenterological Association (AGA) Institute.
NYU Langone Medical Center researchers find altered micriobiome prevalent in the diseased esophagus
Gastroesophageal reflux diseases , or GERD, affects about 10 million people in the United States, yet the cause and an unexpected increase in its prevalence over the last three decades remains unexplainable.
NEJM study finds radiofrequency ablation can reverse Barrett's esophagus, reduce cancer risk
Patients who have gastroesophageal reflux disease (GERD) for a prolonged period have an increased risk of developing Barrett's esophagus, a pre-cancerous condition where the tissue lining the esophagus becomes damaged by stomach acid and transformed into something like the inside of the stomach.
Obesity predicts inadequate bowel prep at colonoscopy
Obesity is an independent predictor of inadequate bowel preparation at colonoscopy, and the presence of additional risk factors further increases the likelihood of a poorly cleansed colon.
Use of acid-suppressive medications associated with increased risk of hospital-acquired pneumonia
Hospitalized patients who receive acid-suppressive medications such as a proton-pump inhibitor have a 30 percent increased odds of developing pneumonia while in the hospital.
Study examines reliability of clinical and pathological diagnoses of Barrett's esophagus
In a review of more than 2,000 patients coded for Barrett's esophagus, electronic diagnosis overestimated the prevalence of the disease according to researchers in California.
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