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What is potentially pathogenic role of anti-tTG IgA in the development of celiac disease?
February 23, 2009The recent detection of antibodies in celiac patients specific for deamidated gliadin peptides (DGP), the product of tTG binding to gliadin peptides, provides an opportunity to address the correlation between the production of anti-tTG IgA and the antibodies against DGP in celiac patients
A research article to be published on February 21, 2009 in the World Journal of Gastroenterology addresses this question. The study group is led by Dr. Marietta, Rashtak, and Murray from the Mayo Clinic in Rochester, MN are of interest to the Celiac Disease community, since the data demonstrate that the serum level of anti-tTG IgA is significantly correlated with the serum level of anti-DGP of both the IgG and IgA isotypes in untreated patients. In contrast, only a weak correlation exists between the production of anti-tTG IgG and anti-DGP IgG/IgA. These data would indicate that the immune response by T and B cells to deamidated gliadin is fundamentally different from the immune response by T and B cells to tissue transglutaminase in celiac patients.
These data would also indicate, however, that the immune responses against deamidated gliadin and tTG are significantly correlated with each other, and thereby provide support for the hapten-carrier theory for the origin of anti-tTG IgA.
World Journal of Gastroenterology
World Journal of Gastroenterology
UM scientists pinpoint critical molecule to celiac disease, possibly other autoimmune disorders
It was nine years ago that University of Maryland School of Medicine researchers discovered that a mysterious human protein called zonulin played a critical role in celiac disease and other autoimmune disorders, such as multiple sclerosis and diabetes.
New therapy may mean less dietary restrictions for celiac sufferers
Scientists have discovered what may be a successful non-dietary therapy for celiac sprue, an inherited inflammatory disorder of the small intestine that impacts an estimated 1 in 200 people around the world.
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Understanding Celiac Disease And Gluten Intolerance: A Video Program For Patients, Physicians, And Health Care Providers Starring: Michelle Pietzak MD, Peter Green MD, Alessio Fasano MD, Shelley Case RD, Robert Anderson MB ChB PhD FRACP Directed By: New Era Productions Adina Sheldon Also With: New Era Productions (Producer), Michelle Pietzak MD (Primary Contributor) Celiac disease and gluten intolerance are poorly understood, with symptoms that mimic many other conditions. Patients with celiac disease often have GI complaints, but can also suffer from anemia, infertility, short stature, IBS, joint pain, osteoporosis, Type I diabetes, neurologic problems, and itchy skin rashes. It can often take more than a decade for a person with celiac disease to receive the correct diagnosis, because patient and physician awareness has been lacking. But now with New Era Productions instructional DVD set, everyone with celiac disease and gluten intolerance, as well as physicians, nurses, dieticians, family, friends, restaurant and food store owners can educate themselves about this common disorder. State of the art 3D animation, as well as an easy menu for quick... |
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Celiac disease predisposes patients to bone loss.(GASTROENTEROLOGY)(Report): An article from: Internal Medicine News by Michele G. Sullivan (Author) This digital document is an article from Internal Medicine News, published by International Medical News Group on May 15, 2009. The length of the article is 552 words. The page length shown above is based on a typical 300-word page. The article is delivered in HTML format and is available immediately after purchase. You can view it with any web browser. Citation Details Title: Celiac disease predisposes patients to bone loss.(GASTROENTEROLOGY)(Report) Author: Michele G. Sullivan Publication: Internal Medicine News (Magazine/Journal) Date: May 15, 2009 Publisher: International Medical News Group Volume: 42 Issue: 10 Page: 25(1) Article Type: Report Distributed by Gale, a part of Cengage... | |
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On the celiac condition: A handbook for celiac patients and their families by Leon H Rottmann (Author) | |
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