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Enhanced skin cancer risk linked to defects in cellular aging controls
February 23, 2009Mouse model of a UV sensitivity syndrome illustrates skin stem cell dysfunction is linked to cancer pathology
Cell lifespan is limited by telomeres, DNA sequences that cap chromosomes and control the number of times a cell may be copied. A new study reported in Disease Models & Mechanisms (DMM), dmm.biologists.org, describes how telomere dysfunction in skin cells can lead to increased skin cancer risk and pigmentation.
Researchers from Spain investigated the molecular mechanisms underlying skin cell telomere dysfunction using a mouse model of Xeroderma Pigmentosum (XP), a disease in which patients have increased sensitivity to ultraviolet (UV) radiation. Their studies revealed that these mice have impaired skin cell regeneration, and that limiting the activity of a tumor suppressor signaling protein, p53, restores cell regeneration and reduces hyperpigmentation. Surprisingly, limiting p53 activity also advances the progression of skin cancers.
This study establishes a link between telomere dysfunction, cancer progression and the dysfunction of DNA repair mechanisms in XP patients. Understanding the pathways which control cell regeneration and cancer progression in these patients will not only aid in treatments for XP patients, but can likewise provide clues on how to target and better treat other cases of skin cancer.
The Company of Biologists
This study establishes a link between telomere dysfunction, cancer progression and the dysfunction of DNA repair mechanisms in XP patients. Understanding the pathways which control cell regeneration and cancer progression in these patients will not only aid in treatments for XP patients, but can likewise provide clues on how to target and better treat other cases of skin cancer.
The Company of Biologists
Skin Cancer Current Events and Skin Cancer News RSSLaser therapy can aggravate skin cancer
High irradiances of low-level laser therapy (LLLT) should not be used over melanomas.
Quarter of a million children in England at risk of skin cancer from sunbeds
An estimated quarter of a million 11-17 year olds in England are being put at increased risk of developing malignant melanoma by using sunbeds, warn researchers in a letter to this week's BMJ.
Hundreds of genes distinguish patients likely to survive advanced melanoma
Although the chances of surviving advanced melanoma aren't very good with current therapies, some patients can live for years with cancer that has spread beyond the skin to other organs.
Adapting Space-Industry Technology to Treat Breast Cancer
Researchers at Rush University Medical Center and Argonne National Laboratory are collaborating on a study to determine if an imaging technique used by NASA to inspect the space shuttle can be used to predict tissue damage often experienced by breast cancer patients undergoing radiation therapy.
Switching immunosuppressants reduces cancer risk in kidney
Switching to a newer type of immunosuppressant drug may reduce the high rate of skin cancer after kidney transplantation, according to research being presented at the American Society of Nephrology's 42nd Annual Meeting and Scientific Exposition in San Diego, CA.
Latest analysis confirms suboptimal vitamin D levels in millions of US children
Millions of children in the United States between the ages of 1 and 11 may suffer from suboptimal levels of vitamin D, according to a large nationally representative study published in the November issue of Pediatrics, accompanied by an editorial.
Geologists studying groundwater arsenic levels in India empower Bengali women, children
A Kansas State University geologist and graduate student are finding that the most important tools in their fieldwork on groundwater arsenic pollution are women and children armed with pamphlets and testing kits.
Melanoma treatment options 1 step closer
A targeted chemotherapy for the treatment of skin cancer is one step closer, after a team of University of Alberta researchers successfully synthesized a natural substance that shows exceptional potential to specifically treat this often fatal disease.
Resident physicians seldom trained in skin cancer examination
Many resident physicians are not trained in skin cancer examinations, nor have they ever observed or practiced the procedure.
Researchers find demand for cosmetic and surgical procedures in dermatologic surgery rising rapidly
Researchers from Boston University School of Medicine (BUSM) and the Laser and Skin Cancer Center of Indiana, (Carmel, Indiana), found that there has been a dramatic increase in the number of procedures performed and patient demand for dermatologic health care since 2000.
More Skin Cancer Current Events and Skin Cancer News Articles
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100 Questions & Answers about Melanoma & Other Skin Cancers by Edward F. McClay (Author), Mary-Eileen T. McClay (Author), Jodie Smith (Author) Whether you're a newly diagnosed skin cancer patient, a survivor, or a friend of either, this book offers help. The only text to provde the doctor and a patient's view, 100 Questions & Answers About Melanoma and Other Skin Cancers gives you authoritative, practical answers to your questions about treatment options, post-treatment quality of life, sources of support, and much more. Written by two skin healthcare professionals and a melanoma survivor, this book is an invaluable resource for anyone coping with the physical and emotional turmoil of this frightening disease. |
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Preventing Skin Cancer DVD Starring: Artist Not Provided If you think that a tan symbolizes good health, you need to become aware of some important facts about the negative effects of exposing your skin to ultraviolet rays. Learn about the various kinds of skin cancer and see how you can protect yourself from a deadly disease. Award Winner: Telly Awards Finalist |
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Melanoma Skin Cancer Awareness Black Genuine Swarovski Crystal Bracelet by SilverSpeck.com This Beautiful Black Genuine Swarovski Crystal Bracelet Is the Perfect Bracelet you have been waiting for. It has a Sparking Glimmer and is beaded on a Comfort Stretch band. Crystal beads can also be used to create your own jewelry! Very Stylish and Pretty! |
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