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Enhanced skin cancer risk linked to defects in cellular aging controls
February 23, 2009Mouse model of a UV sensitivity syndrome illustrates skin stem cell dysfunction is linked to cancer pathology
Cell lifespan is limited by telomeres, DNA sequences that cap chromosomes and control the number of times a cell may be copied. A new study reported in Disease Models & Mechanisms (DMM), dmm.biologists.org, describes how telomere dysfunction in skin cells can lead to increased skin cancer risk and pigmentation.
Researchers from Spain investigated the molecular mechanisms underlying skin cell telomere dysfunction using a mouse model of Xeroderma Pigmentosum (XP), a disease in which patients have increased sensitivity to ultraviolet (UV) radiation. Their studies revealed that these mice have impaired skin cell regeneration, and that limiting the activity of a tumor suppressor signaling protein, p53, restores cell regeneration and reduces hyperpigmentation. Surprisingly, limiting p53 activity also advances the progression of skin cancers.
This study establishes a link between telomere dysfunction, cancer progression and the dysfunction of DNA repair mechanisms in XP patients. Understanding the pathways which control cell regeneration and cancer progression in these patients will not only aid in treatments for XP patients, but can likewise provide clues on how to target and better treat other cases of skin cancer.
The Company of Biologists
This study establishes a link between telomere dysfunction, cancer progression and the dysfunction of DNA repair mechanisms in XP patients. Understanding the pathways which control cell regeneration and cancer progression in these patients will not only aid in treatments for XP patients, but can likewise provide clues on how to target and better treat other cases of skin cancer.
The Company of Biologists
Skin Cancer Current Events and Skin Cancer News RSSHundreds of genes distinguish patients likely to survive advanced melanoma
Although the chances of surviving advanced melanoma aren't very good with current therapies, some patients can live for years with cancer that has spread beyond the skin to other organs.
Adapting Space-Industry Technology to Treat Breast Cancer
Researchers at Rush University Medical Center and Argonne National Laboratory are collaborating on a study to determine if an imaging technique used by NASA to inspect the space shuttle can be used to predict tissue damage often experienced by breast cancer patients undergoing radiation therapy.
Switching immunosuppressants reduces cancer risk in kidney
Switching to a newer type of immunosuppressant drug may reduce the high rate of skin cancer after kidney transplantation, according to research being presented at the American Society of Nephrology's 42nd Annual Meeting and Scientific Exposition in San Diego, CA.
Latest analysis confirms suboptimal vitamin D levels in millions of US children
Millions of children in the United States between the ages of 1 and 11 may suffer from suboptimal levels of vitamin D, according to a large nationally representative study published in the November issue of Pediatrics, accompanied by an editorial.
Geologists studying groundwater arsenic levels in India empower Bengali women, children
A Kansas State University geologist and graduate student are finding that the most important tools in their fieldwork on groundwater arsenic pollution are women and children armed with pamphlets and testing kits.
Melanoma treatment options 1 step closer
A targeted chemotherapy for the treatment of skin cancer is one step closer, after a team of University of Alberta researchers successfully synthesized a natural substance that shows exceptional potential to specifically treat this often fatal disease.
Resident physicians seldom trained in skin cancer examination
Many resident physicians are not trained in skin cancer examinations, nor have they ever observed or practiced the procedure.
Researchers find demand for cosmetic and surgical procedures in dermatologic surgery rising rapidly
Researchers from Boston University School of Medicine (BUSM) and the Laser and Skin Cancer Center of Indiana, (Carmel, Indiana), found that there has been a dramatic increase in the number of procedures performed and patient demand for dermatologic health care since 2000.
Case Western Reserve University discovers Merkel cell originates from skin, not the neural crest
Case Western Reserve University School of Medicine assistant professor of pediatrics, neurosciences and otolaryngology, Stephen M. Maricich, M.D., Ph.D., and his team found that Merkel cells originate in the skin, not the neural crest lineage, as previously speculated.
A potential new imaging agent for early diagnosis of most serious skin cancer
Scientists in Australia are reporting development and testing in laboratory animals of a potential new material for diagnosing malignant melanoma, the most serious form of skin cancer.
More Skin Cancer Current Events and Skin Cancer News Articles
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100 Questions & Answers about Melanoma & Other Skin Cancers by Edward F. McClay (Author), Mary-Eileen T. McClay (Author), Jodie Smith (Author) Whether you're a newly diagnosed skin cancer patient, a survivor, or a friend of either, this book offers help. The only text to provde the doctor and a patient's view, 100 Questions & Answers About Melanoma and Other Skin Cancers gives you authoritative, practical answers to your questions about treatment options, post-treatment quality of life, sources of support, and much more. Written by two skin healthcare professionals and a melanoma survivor, this book is an invaluable resource for anyone coping with the physical and emotional turmoil of this frightening disease. |
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Preventing Skin Cancer DVD Starring: Artist Not Provided If you think that a tan symbolizes good health, you need to become aware of some important facts about the negative effects of exposing your skin to ultraviolet rays. Learn about the various kinds of skin cancer and see how you can protect yourself from a deadly disease. Award Winner: Telly Awards Finalist |
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Skin Cancer by Publiciencia - Rev Congr Unip | |
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Skin Cancer by Keyvan Nouri (Author) The ultimate all-in-one guide to diagnosing and treating skin cancer A Doody's Core Title ESSENTIAL PURCHASE! 4 STAR DOODY'S REVIEW! |
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Radiance C0-Q10 Skin Restorer Face Moisturizer Day Cream for Men & Women + Sensitive Skin by RADIANCE INTERNATIONAL In This amazing French Polynesian blend, Radiance International utilizes Phytelene complexes EGX258 and EGX259 to penetrate, restore, clarify, and hydrolyze the skin from the deepest subcutaneous layer of the derma to the 5th layer of the cell matrix. Clinical studies prove EGX258, an herbal blend of Horsetail, Hedera Ivy, and Ladies Mantle restores connective tissue to its normal composition, even aged skin, by promoting the bodys own production of biosynthesized collagen and elastin by the fibroblast. As a result, proper collagen an elastin functions are enhanced and radiant smooth soft skin is balanced, as lines and wrinkles are diminished around the eyes face and neck. EGX259 is a free-radical scavenging herbal complex is a blend of Milk Thistle, Gingko Biobla, Witch Hazel, amino... |
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CLARISONIC Skin Care Brush Limited Edition Pink, Breast Cancer Awareness + 2 oz Cleanser 1 kit by Pacific Bioscience Laboratories Please note: Due to packaging updates, the image shown may temporarily appear different from the product received. The product you will recieve has one brush head. Clarisonic's limited edition pink ~ Your purchase contributes $10 to fight breast cancer. Comes with 2 oz cleanser Skin is more than your body's supple facade ~ it's the boundary between you and the world. Care for your skin like it cares for you with Clarisonic®. Its gentle sonic vibrations cleanse deeply, clearing your pores for better absorption of skin care ingredients (with no harmful abrasion). Use it daily to keep your skin soft, smooth, and healthy. Waterproof T-Timer1™ Rechargeable This kit includes the Clarisonic® Skin Care Brush, Charger, 1 Brush Head, Trial Size Cleanser (2 oz), and User... |
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Will Ferrell's Sun Stroke Sunscreen Benefiting Cancer For College by Cancer For College What golfer wouldnt want to sport a rich dark tan and add 57 yards to their tee shots? This sunscreen provides improved accuracy, added distance and the ultimate bronzing power...we think. All of our sunscreen products come in 6 oz bottles and are 30 SPF and provide UVA/UVB broad spectrum protection. 100% of the proceeds from sales go to the Cancer for College Scholarship Fund. |
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Blue Lizard Australian Sunscreen, Regular, SPF 30+, 8.75-Ounce Bottle by Blue Lizard Blue Lizard Australian Suncream Regular SPF 30+ is a broad spectrum sun block that is extremely water resistant. Blue Lizard utilizes transparent Zinc Oxide along with chemical blockers to provide broad spectrum protection from both UVA and UVB rays. The packaging is unique as it provides a UV indicator for consumers to know when they need to be wearing suncreen. The bottle turns BLUE when exposed to UV rays. |
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Cancer Be Gone Guided imagery CD taps into the immense power of the mind to enhance comfort, healing, an optimistic attitude and positive expectations. Metaphor of "cancer as weeds in a garden that are easily managed". |
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Skin Cancer Survivor Italian Charm Bracelet by Pugster Together with a stainless steel starter to match your Itallian charm bracelet. Get your message across with this Pugster Skin Cancer Survivor Laser Italian charm. Pugster (TM) Inc.'s laser Italian charms are the finest around, featuring the most current designs and the highest quality. This laser Italian charm will be the perfect addition to your charm bracelet, letting everyone know that you're a skin cancer survivor! This charm would also be a great gift for someone that you know feels the same way you do. Like all laser Italian charms crafted and authenticated by Pugster Inc., this Pugster Skin Cancer Survivor Laser Italian charm is available for both retail and wholesale purchase from our store and is compatible with all major brands.var rf =... |
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