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Human stem cells provide a new model for Lou Gehrig's disease
February 23, 2009Motor neurons derived from embryonic stem cells mimic the progress of familial ALS
Amyotrophic lateral sclerosis (ALS), also known as Lou Gehrig's disease, is a devastating condition in which motor neuron degeneration causes progressive loss of movement and muscle tone, leading to death. Overcoming the limited success of previous models, a report published in Disease Models & Mechanisms (DMM), dmm.biologists.org describes how neurons can be derived from human stem cells, and engineered to mimic inherited ALS.
This human cell-derived model of ALS provides a new method of studying this disease and testing novel therapeutics. This is especially helpful as only one drug is approved to help slow ALS progression, and animal models currently used in drug development have had limited success. Additionally, this research may aid other gene-linked neurodegenerative diseases, as they too may benefit from studies in a human cell-derived model.
The Company of Biologists
Human Stem Cells Current Events and Human Stem Cells News RSSIowa State University researcher discovers key to vital DNA, protein interaction
A researcher at Iowa State University has discovered how a group of proteins from plant pathogenic bacteria interact with DNA in the plant cell, opening up the possibility for what the scientist calls a "cascade of advances."
Experimental treatments restore partial vision to blind people
Two experimental treatments, a retinal prosthesis and fetal tissue transplant, restored some vision to people with blinding eye diseases. The findings, presented at Neuroscience 2009, the annual meeting of the Society for Neuroscience and the world's largest source of emerging news on brain science and health, may lead to new treatments for the blind.
Mice regain ability to extend telomeres suggesting potential for dyskeratosis congenita therapy
The human genetic disease dyskeratosis congenita (DKC) is an autosomal dominant disease that leads to abnormalities in tissues with a rapid cell turnover - the skin, nails, bone marrow, lungs and gut.
Engineered pig stem cells bridge the mouse-human gap
The discovery that adult skin cells can be 'reprogrammed' to behave like stem cells has been a major scientific boon, providing a way to tap the potential of embryonic stem cells without the associated ethical quandaries.
Why do people with Down syndrome have less cancer?
Most cancers are rare in people with Down syndrome, whose overall cancer mortality is below 10 percent of that in the general population.
Scientists Develop Method for Comprehensive Proteome Analysis
Investigators at Burnham Institute for Medical Research (Burnham) have deciphered a large percentage of the total protein complement (proteome) in Schizosaccharomyces pombe (S. pombe) fission yeast.
Stem cell therapy grows new blood vessels
Research led by David Hess of the Robarts Research Institute at The University of Western Ontario has identified how to use selected stem cells from bone marrow to grow new blood vessels to treat diseases such as peripheral artery disease.
Researchers piggyback to safer reprogrammed stem cells
Austin Smith and his research team at the Centre for Stem Cell Research in Cambridge have just published in the journal Development (http://dev.biologists.org/) a new and safer way of generating pluripotent stem cells - the stem cells that can give rise to every tissue of the body.
A budding role for a cellular dynamo
Actin, a globular protein found in all eukaryotic cells, is a workhorse that varies remarkably little from baker's yeast to the human body.
Rice University's Baker Institute experts available to discuss stem cell research, recommendations
Rice University's Baker Institute has experts available to discuss the current debate on United States' embryonic stem cell policy.
More Human Stem Cells Current Events and Human Stem Cells News Articles
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Human Stem Cell Manual: A Laboratory Guide by Jeanne F. Loring (Editor), Robin L. Wesselschmidt (Editor), Philip H. Schwartz (Editor) Stem cells are self-replicating and undifferentiated, meaning their function is not yet cell, tissue, or organ-specific. Due to the unique nature of these cells, research into their biology and function holds great promise for therapeutic applications through replacement or repair of diseased and damaged cells. This reader-friendly manual provides a practical "hands on" guide to the culture of human embryonic and somatic stem cells. By presenting methods for embryonic and adult lines side-by-side, the authors lay out an elegant and unique path to understanding the science of stem cell practice. The authors begin with a broad-based introduction to the field, and also review legal and regulatory issues and patents. Each experimental strategy is presented with an historical introduction,... |
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Charlie Rose with Ron McKay; Uma Thurman; Stephen Gan, Cecelia Dean & James Kaliardos (April 27, 2001) Following today's announcement of major developments in stem cell research, the researcher, Dr. Ron McKay of the National Institute of Health, is on the show. He discusses the possibility that stem cells may help us to better understand the Human Genome. Then, actress Uma Thurman discusses her role in the new Merchant Ivory film, The Golden Bowl. She plays the role of Charlotte Stant the film adaptation of the Henry James novel. Finally, Stephen Gan, Cecelia Dean and James Kaliardos are the editors and co-founders of the fashion and art magazine, Visionaire. They talk about the publication on the occasion of its 10th anniversary. This product is manufactured on demand using DVD-R recordable media. Amazon.com's standard return policy will apply. |
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Stem Cells, Human Embryos and Ethics: Interdisciplinary Perspectives by Lars Østnor (Editor) Is it acceptable from an ethical point of view to use stem cells from human embryos for scientific research and clinical therapy? And what are the weaknesses and strengths of various opinions and positions when they are critically evaluated? These are the main problems dealt with in this book. The various chapters as a whole give a comprehensive, many-sided and balanced discussion of the subject. The book contains contributions from biological, medical, social, political, philosophical and theological perspectives. The authors have been chosen because of their professional competence, many of them being respected scholars on a top international level. They give an updated contribution from their own discipline in order to enlighten the different aspects of the common theme. The... |
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Culture of Human Stem Cells (Culture of Specialized Cells) by R. Ian Freshney (Author), Glyn N. Stacey (Author), Jonathan M. Auerbach (Author) This book collects the most effective and cutting-edge methods and protocols for deriving and culturing human embryonic and adult stem cells—in one handy resource. This groundbreaking book follows the tradition of previous books in the Culture of Specialized Cells Series—each methods and protocols chapter is laid out exactly like the next, with stepwise protocols, preceded by specific requirements for that protocol, and a concise discussion of methods illustrated by data. The editors describe a limited number of representative techniques across a wide spectrum of stem cells from embryonic, newborn, and adult tissue, yielding an all-encompassing and versatile guide to the field of stem cell biology and culture. The book includes a comprehensive list of suppliers... |
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Human Stem Cells: Source of Hope and of Controversy by Henk Jochemsen (Author) |
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Human Embryonic Stem Cell Protocols (Methods in Molecular Biology) by Kursad Turksen (Editor) Despite political and ethical controversies surrounding the study of human embryonic stem (hES) cells, new freedoms in regard to using them for research has allowed interest to remain high in understanding the regulatory mechanisms of stem cell self-renewal, their differentiation along various lineages, and their potential use in regenerative medicine. In Human Embryonic Stem Cell Protocols, Second Edition, internationally respected researchers expand upon the popular first edition and describe in detail their most useful techniques for the molecular and cellular manipulation of these intriguing cells. This diverse collection of readily reproducible methods has been optimized for the derivation, characterization, and differentiation of hES cells, with special attention given to... |
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Human Embryonic Stem Cells: The Practical Handbook by Stephen Sullivan (Editor), Chad A Cowan (Editor), Kevin Eggan (Editor) With this valuable practical guide, three members of the Harvard Stem Cell Institute have compiled and edited the definite handbook for the exciting new field of human embryonic stem cell research. The editors have gathered protocols from scientists with extensive reputation and expertise, describing and comparing currently used techniques for the culture of human stem cells and discussing the strengths and weaknesses of the different approaches. Human Embryonic Stem Cells: The Practical Handbook contains the first centralised collection of methods used in human embryonic stem cell biology. The book covers the derivation of human stem cell lines, the obtaining of cells from human stem cell banks, the culturing and characterisation of the cells, and the differentiation of the... |
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Charlie Rose with Harold Varmus & Sam Brownback; John Browne (April 10, 2002) Following the news that the president has said he supports legislation to ban all human cloning, a conversation with Senator Sam Brownback of Kansas and Dr. Harold Varmus, president of the Memorial Sloan-Kettering Cancer Center. Also, CEO of British Petroleum, Lord John Brown, talks about the future of the oil industry. This product is manufactured on demand using DVD-R recordable media. Amazon.com's standard return policy will apply. |
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Testing human stem cells in primates.(Guest Editorial)(Editorial): An article from: Family Practice News by Guy McKhann (Author) This digital document is an article from Family Practice News, published by Thomson Gale on August 15, 2005. The length of the article is 524 words. The page length shown above is based on a typical 300-word page. The article is delivered in HTML format and is available in your Amazon.com Digital Locker immediately after purchase. You can view it with any web browser. Citation Details Title: Testing human stem cells in primates.(Guest Editorial)(Editorial) Author: Guy McKhann Publication: Family Practice News (Magazine/Journal) Date: August 15, 2005 Publisher: Thomson Gale Volume: 35 Issue: 16 Page: 14(1) Article Type: Editorial Distributed by Thomson... | |
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Time Magazine July 23 2001 How Apes Became Human * Stem Cells: The Battle Heats Up * Gary Condit's Secret Life by Time Magazine (Author) |
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