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Is esomeprazole the best choice for reflux esophagitis patients?
March 03, 2009In patients with gastroesophageal reflux disease (GERD), esomeprazole, has demonstrated pharmacological and clinical benefits beyond those seen with the other proton pump inhibitors( PPIs ). However it has not hitherto been fully determined whether differences in the onset of antisecreatary activity may affect the speed of symptom relief with different PPI.
Dr. Ri-Nan Zheng from China addresses this question. He investigated whether there is any difference in the symptom relief in patients with reflux esophagitis following the administration of four PPIs (omeprazole, lansoprazole, pantoprazole, esomeprazole). This will be published on February 28, 2009 in the World Journal of Gastroenterology.
In this study, two hundred and seventy-four patients with erosive reflux esophagitis were randomized to receive 8 wk of 20 mg omeprazole (n = 68), 30 mg of lansoprazole (n = 69), 40 mg of pantoprazole (n = 69), 40 mg of esomeprazole (n = 68) once a day in the morning. Daily changes in heartburn and acid reflux symptoms in the first 7 d of administration were assessed using a six-point scale (0: none; 1: mild; 2: mild-moderate; 3: moderate; 4: moderate-severe; 5: severe).
He found that the mean heartburn score in patients treated with esomeprazole more rapidly decreased than those receiving other PPI. Complete resolution of heartburn was also more rapid in patients treated with esomeprazole for 5 d compared with omeprazole (P = 0.0018, P = 0.0098, P = 0.0027, P = 0.0137, P = 0.0069, respectively), lansoprazole (P = 0.0020, P = 0.0046, P = 0.0037, P = 0.0016, P = 0.0076, respectively), and pantoprazole (P = 0.0006, P = 0.0005, P = 0.0009, P = 0.0031, P = 0.0119, respectively). There were no significant differences between the four groups in the rate of endoscopic healing of reflux esophagitis at week 8.
The results indicated that esomeprazole may be more effective than omeprazole, lansoprazole, and pantoprazole for the rapid relief of heartburn symptoms and acid reflux symptoms in patients with reflux esophagitis.
World Journal of Gastroenterology
He found that the mean heartburn score in patients treated with esomeprazole more rapidly decreased than those receiving other PPI. Complete resolution of heartburn was also more rapid in patients treated with esomeprazole for 5 d compared with omeprazole (P = 0.0018, P = 0.0098, P = 0.0027, P = 0.0137, P = 0.0069, respectively), lansoprazole (P = 0.0020, P = 0.0046, P = 0.0037, P = 0.0016, P = 0.0076, respectively), and pantoprazole (P = 0.0006, P = 0.0005, P = 0.0009, P = 0.0031, P = 0.0119, respectively). There were no significant differences between the four groups in the rate of endoscopic healing of reflux esophagitis at week 8.
The results indicated that esomeprazole may be more effective than omeprazole, lansoprazole, and pantoprazole for the rapid relief of heartburn symptoms and acid reflux symptoms in patients with reflux esophagitis.
World Journal of Gastroenterology
Esomeprazole Current Events and Esomeprazole News RSSAcid-reducing medicines may lead to dependency
Treatment with proton pump inhibitors (PPIs) for eight weeks induces acid-related symptoms like heartburn, acid regurgitation and dyspepsia once treatment is withdrawn in healthy individuals.
Technique eradicates problems in most patients with Barrett's esophagus
A procedure that uses heat generated by radio waves to treat Barrett's esophagus, a condition caused by acid reflux (severe heartburn), can eliminate signs of the potentially cancer-causing disorder and reduce the risk that the disease will progress.
Study shows benefits of anti-clotting medications reduced by common heartburn drugs
The anti-clotting action of the medication clopidogrel (Plavix) can be compromised by common drugs for the treatment of heartburn and ulcers resulting in a roughly 50% increase in the combined risk of hospitalization for heart attack, stroke and other serious cardiovascular illnesses.
Heartburn medications do not ease asthma symptoms
The predominance of heartburn among asthma sufferers led many specialists to suspect that acid reflux could be a trigger for the coughing, wheezing and breathlessness of asthma.
What cures your aches might prevent cancer
Mayo Clinic Cancer Center has begun three clinical studies looking at the use of nonsteroidal anti-inflammatory drugs (NSAIDs) to prevent cancer - colon, esophageal or lung.
New study shows erosive esophagitis healing linked to acid control
New clinical data demonstrated, for the first time in a prospective study, a direct relationship between controlling gastric (or stomach) acid and healing erosive esophagitis caused by acid reflux disease.
Gut Reactions in Europe and US
Heartburn disease: A story of sleep, sex and suffering 22 May 2001 – Mölndal, Sweden – Eating, sleeping, sport and sex - activities that are supposed to be part of life’s pleasures are for a large group of people, being disrupted on a daily basis by an unlikely culprit – heartburn. More than 50 million Europeans (imagine the entire populations of Sweden, Denmark, Norway, Finland, Ireland, Netherlands and Austria combined1) suffer from heartburn disease, a condition in which stomach acid flows back into the esophagus causing an unpleasant burning pain and acid taste. Results of a pan-European survey, involving more than 5000 people in France, Germany, Italy, Sweden a
New Study on confirmatory Test Diagnosis for GastroEsophageal Reflux Disease
22 May 2001 - Mölndal, Sweden - The majority of patients presenting with chronic and frequent heartburn will be eventually diagnosed with gastroesophageal reflux disease (GERD). At present, the only means to confirm a suspected diagnosis, made by a physician following an analysis of symptom history, is endoscopy or pH monitoring, both expensive procedures often only available after a long wait. Currently, each year, endoscopic procedures cost US $ 22.6 million in Sweden alone.1 However, new data, presented today at the Digestive Diseases Week, Atlanta, USA suggests that patients presenting with chronic heartburn and free of alarm symptoms* could be prescribed a standard dose of esomeprazole
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