 |
|
DNA differences may influence risk of Hodgkin disease
March 09, 2009A new analysis has found that certain variations in genes that repair DNA can affect a person's risk of developing Hodgkin disease. Published in the April 1, 2009 issue of CANCER, a peer-reviewed journal of the American Cancer Society, the study indicates that differences in these genes should be further investigated to better understand individuals' susceptibility to this type of cancer.
Proteins that repair damage to DNA are important for maintaining cells' health, particularly for preventing the accumulation of genetic damage that could increase the chances of becoming cancerous. Researchers have found that, in the general population, there are variations in the genes that encode these DNA repair proteins. Research has also shown a link between reduced DNA repair and susceptibility to a variety of cancers, including breast, colon, and lung cancer.
To determine the potential role of genetic variants-or polymorphisms-in DNA repair genes in the development of Hodgkin disease, Dr. Randa El-Zein and colleagues at The University of Texas M.D. Anderson Cancer Center in Houston evaluated the relationship between polymorphisms in five DNA repair genes (XPC, XPD, XPG, XRCC1, and XRCC3) in a population of 200 Hodgkin disease patients and 220 healthy individuals.
These five genes are involved in different pathways that repair DNA by performing different modifications to damaged DNA. Changes in these genes can change the make-up and structure of the proteins that carry out these repair processes and therefore could influence how well DNA repair is performed.
The researchers found that variations in DNA repair genes may modify the risk of HD especially when interactions between the pathways are considered. Depending on the variant or combination thereof, people could be, up to four times more likely to develop the disease.
The authors concluded that "these data suggest that genetic polymorphisms in DNA repair genes may modify the risk of Hodgkin disease especially when interactions between the pathways are considered." They added that genetic variants in the different DNA repair pathways should be further evaluated to better understand their role in Hodgkin disease susceptibility in individuals.
American Cancer Society
These five genes are involved in different pathways that repair DNA by performing different modifications to damaged DNA. Changes in these genes can change the make-up and structure of the proteins that carry out these repair processes and therefore could influence how well DNA repair is performed.
The researchers found that variations in DNA repair genes may modify the risk of HD especially when interactions between the pathways are considered. Depending on the variant or combination thereof, people could be, up to four times more likely to develop the disease.
The authors concluded that "these data suggest that genetic polymorphisms in DNA repair genes may modify the risk of Hodgkin disease especially when interactions between the pathways are considered." They added that genetic variants in the different DNA repair pathways should be further evaluated to better understand their role in Hodgkin disease susceptibility in individuals.
American Cancer Society
Novel therapeutic approaches may improve patient outcomes in several platelet disorders
Four studies that highlight significant advances in treatment and survival outcomes for patients with various forms of thrombocytopenia, a group of bleeding disorders characterized by a low number of platelets in the blood.
Study analyzes heart attack mortality risk associated with Hodgkin disease treatments
Doctors have long known that patients treated for Hodgkin disease are at an increased risk for heart attacks.
Survivors of childhood leukemia, brain tumors more at risk for strokes later in life
Children who are successfully treated for brain tumors or leukemia are more likely to have strokes later in life, according to new research from UT Southwestern Medical Center.
Hodgkin disease survivors face higher risk for stroke later in life
Patients surviving childhood Hodgkin disease suffer strokes later in life at rates about four times that of the general population, UT Southwestern Medical Center researchers have found.
Model predicts risk of breast cancer for young women treated for Hodgkin lymphoma
Young women who are treated for Hodgkin lymphoma with chest radiation therapy have a high cumulative absolute risk of developing breast cancer later in life.
More Hodgkin Disease Current Events and Hodgkin Disease News Articles
 |
Hodgkin's Disease by Peter M. Mauch (Editor), James O. Armitage (Editor), Volker, M.D. Diehl (Editor), Richard T., M.D. Hoppe (Editor), Lawrence M. Weiss (Editor) Harvard Medical School, Boston, MA. Reference, for residents, practitioners, and researchers, on the etiology and epidemiology, staging and evaluation, treatment and techniques, selection of treatment, and late effects of treatment. Extensive references are included. Color and halftone illustrations. DNLM: Hodgkin Disease. Added to Brandon-Hill Medical List in April 2001. |
 |
Hodgkin's and Non-Hodgkin's Lymphoma (Cancer Treatment and Research) by John P. Leonard (Editor), Morton Coleman (Editor) Over recent years, there has been a dramatic increase in knowledge of the biology of the lymphomas which has been accompanied by the emergence of new treatments that offer both improvements in efficacy and reduction in toxicity. Molecular profiling of tumor tissue and other new advances have led to a better understanding of the genetic basis of lymphoma, identification of new therapeutic targets, and potentially valuable prognostic information. Monoclonal antibody therapies, radioimmunoconjugates and other new agents such as proteosome inhibitors are providing important new treatment options for patients. In this volume, an internationally recognized group of experts provides a comprehensive overview of the biology, pathology, standard treatments, and novel approaches in management of... |
 |
Hodgkin's Disease Awareness Ribbon Mouse Pad by MyHeritageWear.com The Hodgkin's Disease Ribbon proudly displayed on a mouse pad. There is no better way to achieve awareness for the meaning of the Hodgkin's Disease Ribbon than to display it on your mouse pad for everyone to see. The mouse pad measures at 9.25 x 7.75, it is machine washable, and the colors will not fade or run. Start gaining awareness today by presenting your Hodgkin's Disease Ribbon mouse pad at work or at home. It is certain to keep your mouse rolling in style all while gaining support and awareness! |
 |
ABC News Nightline Life and Death: Episodes 1-4 'Life and Death,'' chronicles the journey of four people facing life threatening illnesses, as they struggle with their families to battle despair and celebrate life. EPISODE 1: FINDING A DONOR: Stephen Dzemian is trying to find a live donor to risk his or her own life to save him. EPISODE 2: A MOTHER'S ILLNESS: Aimee Chamernik is dieing of amyotrophic lateral sclerosis -- the illness known as Lou Gehrig's disease. EPISODE 3: FRANK'S STORY: Frank O'Day who is battling Stage 4 Hodgkin's Lymphoma. EPISODE 4: DIEING WITH DIGNITY: Glenn Elfman, who was diagnosed with cancer that is terminal, discusses physician-assisted suicide with his wife. This product is manufactured on demand using DVD-R recordable media. Amazon.com's standard return policy will apply. |
 |
Hodgkin Lymphoma by Richard T Hoppe (Editor), Peter M Mauch (Editor), James O Armitage (Editor), Volker Diehl (Editor), Lawrence M Weiss (Editor) The definitive text on Hodgkin lymphoma is now in its thoroughly revised, updated Second Edition. More than 100 recognized authorities from all parts of the world provide comprehensive, current information on every aspect of Hodgkin lymphoma, including etiology, epidemiology, biology, pathology, evaluation, staging, treatment, and follow-up. This edition describes the increased use of PET scanning in staging and follow-up. Chapters discuss current treatment options—including combination chemotherapy, radiation therapy, novel treatment techniques, and hematopoietic stem cell transplantation—and offer guidelines for treatment selection. Full consideration is given to late effects of therapy and clinical trials for assessing quality of life in patients. This edition includes... |
 |
Hodgkin's Disease (Diseases and Disorders) by Sheila Wyborny (Author) |
 |
Hodgkin's Disease Medical Guide by Qontro Medical Guides (Author) The Hodgkin's Disease Medical Guide is a publication which has been designed to better help readers understand Hodgkin's Disease. This Qontro Medical Guide has been designed with the reader in mind, and is a useful information source for readers at all levels looking to learn more about Hodgkin's Disease. The Hodgkin's Disease Medical Guide is highly recommended for those interested in understanding and learning more about Hodgkin's Disease. |
|
Bang the Drum Slowly Starring: Barbara Babcock, Robert De Niro, Selma Diamond, Phil Foster, Vincent Gardenia Directed By: John Hancock Studio: Paramount Home Video Release Date: 03/28/2006 | |
|
Hodgkin's Disease: The Consequences of Survival by Mortimer J. Lacher (Author), John R. Redman (Author) | |
 |
The Official Patient's Sourcebook on Adult Hodgkin's Disease: A Revised and Updated Directory for the Internet Age by Icon Health Publications (Author) This book has been created for patients who have decided to make education and research an integral part of the treatment process. Although it also gives information useful to doctors, caregivers and other health professionals, it tells patients where and how to look for information covering virtually all topics related to adult hodgkin's disease (also Cancer Hodgkin's lymphoma; Hodgkin Disease; Hodgkin's disease; Hodgkin's Lymphoma; Lymphoma Hodgkin's; Malignant lymphoma), from the essentials to the most advanced areas of research. The title of this book includes the word official. This reflects the fact that the sourcebook draws from public, academic, government, and peer-reviewed research. Selected readings from various agencies are reproduced to give you some of the latest official... |
| © 2009 BrightSurf.com |