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Iron induces death in tumor cells
March 11, 2009Rapid growth of cancer cells and their frequent divisions have their price: Cancer cells need considerably more energy than healthy cells. Their metabolism runs at full speed and requires large amounts of micronutrients, particularly iron. However, high levels of iron in the cell lead to the production of extremely harmful free radicals. To protect itself from these, the cell inactivates free iron by binding it to what are called iron storage proteins.
Collaborating with physicians of the Dermatology Department of Mannheim University Hospitals, Dr. Karsten Gülow and Professor Dr. Peter Krammer, head of the Division of Immunogenetics at DKFZ, investigated Sézary's disease (also called Sézary syndrome), an extremely aggressive type of cutaneous T cell lymphoma. The majority of currently available treatments are not really effective against this fatal type of cancer.
Using a molecular-biological trick, Gülow and colleagues succeeded in blocking the production of one of the iron storage proteins in lymphoma cells. This leads to a rise in the level of free, non-bound iron in these cells. The iron boosts the production of free oxygen radicals which cause oxidative stress and, thus, cause damage to the cancer cells and induce their death. Healthy cells with their low iron level, however, survive the treatment unharmed.
The DKFZ researchers have already found evidence that this iron effect also works in other lymphomas. They are now investigating whether selective release of iron may be a suitable approach for developing a novel cancer treatment.
Helmholtz Association of German Research Centres
The DKFZ researchers have already found evidence that this iron effect also works in other lymphomas. They are now investigating whether selective release of iron may be a suitable approach for developing a novel cancer treatment.
Helmholtz Association of German Research Centres
Cancer Cells Current Events and Cancer Cells News RSSResearchers Identify Role of Gene in Tumor Development, Growth and Progression
Virginia Commonwealth University Massey Cancer Center and VCU Institute of Molecular Medicine researchers have identified a gene that may play a pivotal role in two processes that are essential for tumor development, growth and progression to metastasis.
Cancer metabolism discovery uncovers new role of IDH1 gene mutation in brain cancer
Agios Pharmaceuticals today announced that its scientists have established, for the first time, that the mutated IDH1 gene has a novel enzyme activity consistent with a cancer-causing gene, or oncogene.
New cancer target for non-Hodgkin's lymphoma
Physician-scientists from Weill Cornell Medical College have discovered a molecular mechanism that may prove to be a powerful target for the treatment of non-Hodgkin's lymphoma, a type of cancer that affects lymphocytes, or white blood cells.
Common pain relief medication may encourage cancer growth
Although morphine has been the gold-standard treatment for postoperative and chronic cancer pain for two centuries, a growing body of evidence is showing that opiate-based painkillers can stimulate the growth and spread of cancer cells.
Cancers' Sweet Tooth May Be Weakness
The pedal-to-the-metal signals driving the growth of several types of cancer cells lead to a common switch governing the use of glucose, researchers at Winship Cancer Institute of Emory University have discovered.
UCLA researchers create 'fly paper' to capture circulating cancer cells
Just as fly paper captures insects, an innovative new device with nano-sized features developed by researchers at UCLA is able to grab cancer cells in the blood that have broken off from a tumor.
Paradoxical protein might prevent cancer
One difficulty with fighting cancer cells is that they are similar in many respects to the body's stem cells. By focusing on the differences, researchers at Karolinska Institutet have found a new way of tackling colon cancer. The study is presented in the prestigious journal Cell.
Cornell researchers identify a weak link in cancer cell armor
The seeming invincibility of cancerous tumors may be crumbling, thanks to a promising new gene therapy that eliminates the ability of certain cells to repair themselves.
Aileron collaborates study in Nature: Stapled peptides inhibit Notch1 transcription factor
This research validates the potential for Stapled Peptides to modulate key intracellular biological targets, such as transcription factors, that have not been addressable with current small molecule or biologic drug modalities.
Researchers 'notch' a victory toward new kind of cancer drug
Scientists have devised an innovative way to disarm a key protein considered to be "undruggable," meaning that all previous efforts to develop a drug against it have failed.
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One Renegade Cell: The Quest For The Origin Of Cancer (Science Masters) by Robert A. Weinberg (Author) For everyone whose life has been touched by cancer, One Renegade Cell tells the story of the search for the ultimate causes of this dreaded disease. "One Renegade Cell…offers a breathtaking picture, both wonderful and frightening, of the fantastic intricacy of aberrant cellular functioning." -New York Times "Part primer, part history and part meditation. [One Renegade Cell] succeeds on all counts." -Wall Street Journal One of the leading cancer researchers in the world, Robert A. Weinberg is perfectly suited to describe the search for cancer's origins from the early days of this century to the present. Presuming little knowledge of biology, he tells how a cancer-causing virus was first discovered in 1909, how the correlation was made between chemical ... |
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Destroying Cancer Cells Using Your Subconscious Mind a Guided Imagery and Subliminal program Starring: Steve Murray Directed By: Steve Murray The DVD has two separate "Destroying Cancer Cells" self-help programs: A Guided Imagery and a Subliminal program. Both have easy-to-follow directions and can be used before, during, and after cancer treatments. Guided Imagery is the language of the mind. It is a way of communicating with parts of the body that cannot speak in words. You will learn this language in the DVD. Research has shown Guided Imagery is a powerful self-help tool. The Guided Imagery program starts with a relaxation technique, then guides you through ten imagery segments. Subliminal Messages have been used for years by advertisers to reprogram and change one s subconscious mind about their products. With this DVD, you will use Subliminal Message s for your benefit. During the subliminal program all you have to do is... |
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Cancer and the Immune System : Cell-to-Cell Communication, An Introduction (31 minute colour VHS video) (NTSC video) by Spektrum Videothek Produced in Germany. In English. "This documentary focuses on... findings in immunilogical research." | |
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Dissolving & Destroying Cancer Cells "A Guided Imagery Program" [VHS] Also With: steve murray (Primary Contributor) Steve Murray the author of "Cancer Guided Imagery Program for Radiation, Chemotherapy, Surgery and Recovery" now has a series of DVDs and Videos that will help you: Tap into the Healing Power of the Body and Mind Connection This program when used in conjunction with your prescribed medical treatment shows you how to do just that. With easy to understand explanations and directions, you will be able to start a Cancer Guided Imagery Program right away. Guided Imagery is the language of the mind. It is a way of communicating with parts of ourselves that cannot speak in words. You will use this language in the program. Program Includes: -Directions on how to do program-Guided relaxation and ten Cancer Guided Imagery segments-Soothing music, calm peaceful images- Verbal and... |
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Antioxidant + Resveratrol , (60 Capltes/bottle) This product provides nutritional support to defend against the effects of free radicals. Resveratrol is a type of polyphenol called a phytoalexin. Resvertraol works by binding to a class of proteins called sirtuins, which regulate the enzymes that can stimulate cancer-cell growth and suppress immune response. Resveratrol may also have powerful and diverse effects on the heart and blood vessels. by Vitamore Free-radicals (also called oxidants) are highly unstable molecules that can damage cell membranes. This may start a process that leads to several chronic diseases and may be involved with many aspects of aging. Free radicals are produced in the body during normal cell metabolism, and may also be caused by other environmental and lifestyle factors such as stress, smoking, polution, etc. This product provides nutritional support to defend against the effects of free radicals using the antioxidant vitamins of C and E and the trace elements of Zinc and Selenium. The key ingredient is the flavonoid-rich Resveratrol. Resveratrol is a type of polyphenol called a phytoalexin. Resvertraol works by binding to a class of proteins called sirtuins, which regulate the enzymes that can stimulate... |
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