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Anesthesia or hypothermia: Warning for Alzheimer's patients
March 12, 2009Notice to health-care professionals: New research published online in the FASEB Journal shows that slight dips in brain temperature causes build-up of abnormal tau protein
Everyone knows that its important to keep a cool head, but a new study published online in The FASEB Journal (http://www.fasebj.org) shows that for Alzheimer's patients, a cool head may make the disease worse. In the research report, scientists show that a protein associated with Alzheimer's (called "tau") builds up in brain cells at an increased rate when temperatures fall, such as when a patient is anesthetized or experiences hypothermia. This finding should be of immediate concern to surgeons, dentists, and any other health care professionals who anesthetize patients with Alzheimer's or patients at an elevated risk for the disease.
"We hope that this research will initiate an interest in taking precautions to limit the impact of anesthesia on the disease," said Emmanuel Planel of Columbia University Medical Center and one of the scientists involved in the work.
To make this discovery, the scientists used two groups of mice that make the abnormal tau protein that accumulates in Alzheimer's patients. One group was anesthetized, and one group was not. A week after anesthesia, the two groups were compared for the amount of tau protein clumps in their brain cells. The anesthetized group had more of these clumps than the group that was not anesthetized. Furthermore, in mice showing advanced signs of the disease, the build up of tau proteins occurred faster than in those in the early stages.
"Every patient wants a surgeon with a cool head," said Gerald Weissmann, M.D., Editor-in-Chief of The FASEB Journal, "but surgeons might not want the same for their patients. People are anesthetized for all kinds of reasons, even dental work, but this study really should make patients and doctors reconsider whether it's really necessary."
Federation of American Societies for Experimental Biology
To make this discovery, the scientists used two groups of mice that make the abnormal tau protein that accumulates in Alzheimer's patients. One group was anesthetized, and one group was not. A week after anesthesia, the two groups were compared for the amount of tau protein clumps in their brain cells. The anesthetized group had more of these clumps than the group that was not anesthetized. Furthermore, in mice showing advanced signs of the disease, the build up of tau proteins occurred faster than in those in the early stages.
"Every patient wants a surgeon with a cool head," said Gerald Weissmann, M.D., Editor-in-Chief of The FASEB Journal, "but surgeons might not want the same for their patients. People are anesthetized for all kinds of reasons, even dental work, but this study really should make patients and doctors reconsider whether it's really necessary."
Federation of American Societies for Experimental Biology
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Anesthesia is found to induce hyperphosphorylation of tau at sites related to Alzheimer's disease
Scientists from The New York State Office of Mental Retardation and Developmental Disabilities' (OMRDD) New York State Institute for Basic Research in Developmental Disabilities (IBR) report today in the March 2009 issue of the Journal of Alzheimer's Disease that anesthesia induces phosphorylation of tau.
Blood test predicts chance of dementia
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