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No hiding place for infecting bacteria
March 16, 2009Preventing Pseudomonas aeruginosa biofilms
Scientists in Colorado have discovered a new approach to prevent bacterial infections from taking hold. Writing in the Journal of Medical Microbiology, Dr Quinn Parks and colleagues describe how they used enzymes against products of the body's own defence cells to prevent Pseudomonas aeruginosa bacteria from building a protective biofilm which enables them to avoid both the body's immune mechanisms and antibiotics.
When the body's defence cells, called neutrophils, attack P. aeruginosa, the cell contents - including a protein called F-actin and the cell's DNA - are released. P. aeruginosa uses these cell proteins as a scaffold to build a protective biofilm making these infections very difficult to treat. P. aeruginosa biofilms cause disease in burns, wounds, contact lens infections and are particularly prevalent in the lungs of cystic fibrosis patients.
"We specifically targeted the F-actin protein with a negatively charged peptide, and the DNA with the enzyme DNase, which both prevented and disrupted the formation of P. aeruginosa biofilms in the presence of human neutrophils." said Dr Parks. "These results suggest a new combined therapeutic strategy for the treatment of P. aeruginosa infections.
Society for General Microbiology
"We specifically targeted the F-actin protein with a negatively charged peptide, and the DNA with the enzyme DNase, which both prevented and disrupted the formation of P. aeruginosa biofilms in the presence of human neutrophils." said Dr Parks. "These results suggest a new combined therapeutic strategy for the treatment of P. aeruginosa infections.
Society for General Microbiology
Strategy Discovered for Fighting Persistent Bacterial Infections
Researchers at National Jewish Health have discovered a promising strategy for destroying the molecular scaffolding that can make Pseudomonas bacterial infections extremely difficult to treat in cystic fibrosis patients, wearers of contact lenses, and burn victims. Jerry Nick, MD, Associate Professor of Medicine at National Jewish Health, and his colleagues report in the April 2009 issue of The Journal of Medical Microbiology that a long string of aspartic acid molecules disrupts the molecular bonds that hold together the structure supporting Pseudomonas biofilms.
Putting a stop to antibiotic resistance with new drugs from seaweed
Scientists have found a new way to prevent life-threatening infections not by killing the bacteria but by preventing them from talking to each other, according to research published today in the journal Microbiology. We`ve found that a group of chemicals called furanones can prevent the build up of communities of bacteria on surfaces such as surgical implants and in the lungs of cystic fibrosis (CF) patients, says Dr Michael Givskov of the Technical University of Denmark, Copenhagen. These communities called biofilms are formed after invading bacteria signal to each other to settle down and defend themselves. Biofilm bacteria are protected by a slimy coating, which prevents antibiotics from
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Microbially-mediated glass dissolution and sorption of metals by Pseudomonas aeruginosa cells and biofilm [An article from: Journal of Hazardous Materials] by G. Aouad (Author), J.L. Crovisier (Author), V.A. Geoffroy (Author), J. Meyer (Author) This digital document is a journal article from Journal of Hazardous Materials, published by Elsevier in 2006. The article is delivered in HTML format and is available in your Amazon.com Media Library immediately after purchase. You can view it with any web browser. Description: A basaltic glass and a vitrified bottom ash were incubated at 25^oC in a growth medium (based on casaminoacids) inoculated with Pseudomonas aeruginosa. Bacterial growth and mineral concentrations in different compartments (bacterial cells, growth medium and biofilm) were monitored in short-term (3 days), and long-term experiments involving repeated renewals of the culture medium during 174 days. In short-term experiments, while the concentration of iron increased in the presence of bacteria, a decrease... |
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