 |
|
Nanoscopic probes can track down and attack cancer cells
March 16, 2009A researcher has developed probes that can help pinpoint the location of tumors and might one day be able to directly attack cancer cells.
Joseph Irudayaraj, a Purdue University associate professor of agricultural and biological engineering, developed the nanoscale, multifunctional probes, which have antibodies on board, to search out and attach to cancer cells.
A paper detailing the technology was released last week in the online version of Angewandte Chemie, an international chemistry journal.
"If we have a tumor, these probes should have the ability to latch on to it," Irudayaraj said. "The probe could carry drugs to target, treat as well as reveal cancer cells."
Scientists have developed probes that use gold nanorods or magnetic particles, but Irudayaraj's nanoprobes use both, making them easier to track with different imaging devices as they move toward cancer cells.
The magnetic particles can be traced through the use of an MRI machine, while the gold nanorods are luminescent and can be traced through microscopy, a more sensitive and precise process. Irudayaraj said an MRI is less precise than optical luminescence in tracking the probes, but has the advantage of being able to track them deeper in tissue, expanding the probes' possible applications.
The probes, which are about 1,000 times smaller than the diameter of a human hair, contain the antibody Herceptin, used in treatment of metastatic breast cancer. The probes would be injected into the body through a saline buffering fluid, and the Herceptin would find and attach to protein markers on the surface of cancer cells.
"When the cancer cell expresses a protein marker that is complementary to Herceptin, then it binds to that marker," Irudayaraj said. "We are advancing the technology to add other drugs that can be delivered by the probes."
Irudayaraj said better tracking of the nanoprobes could allow doctors to pinpoint the location of known tumors and better treat the cancer.
The novel probes were tested in cultured cancer cells. Irudayaraj said the next step would be to run a series of tests in mice models to determine the dose and stability of the probes.
The research was funded through a National Institute of Health grant, as well as by the Purdue Research Foundation. Irudayaraj is head of a biological engineering team that includes postdoctoral researcher Chungang Wang and graduate student Jiji Chen.
Purdue University
"If we have a tumor, these probes should have the ability to latch on to it," Irudayaraj said. "The probe could carry drugs to target, treat as well as reveal cancer cells."
Scientists have developed probes that use gold nanorods or magnetic particles, but Irudayaraj's nanoprobes use both, making them easier to track with different imaging devices as they move toward cancer cells.
The magnetic particles can be traced through the use of an MRI machine, while the gold nanorods are luminescent and can be traced through microscopy, a more sensitive and precise process. Irudayaraj said an MRI is less precise than optical luminescence in tracking the probes, but has the advantage of being able to track them deeper in tissue, expanding the probes' possible applications.
The probes, which are about 1,000 times smaller than the diameter of a human hair, contain the antibody Herceptin, used in treatment of metastatic breast cancer. The probes would be injected into the body through a saline buffering fluid, and the Herceptin would find and attach to protein markers on the surface of cancer cells.
"When the cancer cell expresses a protein marker that is complementary to Herceptin, then it binds to that marker," Irudayaraj said. "We are advancing the technology to add other drugs that can be delivered by the probes."
Irudayaraj said better tracking of the nanoprobes could allow doctors to pinpoint the location of known tumors and better treat the cancer.
The novel probes were tested in cultured cancer cells. Irudayaraj said the next step would be to run a series of tests in mice models to determine the dose and stability of the probes.
The research was funded through a National Institute of Health grant, as well as by the Purdue Research Foundation. Irudayaraj is head of a biological engineering team that includes postdoctoral researcher Chungang Wang and graduate student Jiji Chen.
Purdue University
Cancer Cells Current Events and Cancer Cells News RSSCommon pain relief medication may encourage cancer growth
Although morphine has been the gold-standard treatment for postoperative and chronic cancer pain for two centuries, a growing body of evidence is showing that opiate-based painkillers can stimulate the growth and spread of cancer cells.
Cancers' Sweet Tooth May Be Weakness
The pedal-to-the-metal signals driving the growth of several types of cancer cells lead to a common switch governing the use of glucose, researchers at Winship Cancer Institute of Emory University have discovered.
UCLA researchers create 'fly paper' to capture circulating cancer cells
Just as fly paper captures insects, an innovative new device with nano-sized features developed by researchers at UCLA is able to grab cancer cells in the blood that have broken off from a tumor.
Paradoxical protein might prevent cancer
One difficulty with fighting cancer cells is that they are similar in many respects to the body's stem cells. By focusing on the differences, researchers at Karolinska Institutet have found a new way of tackling colon cancer. The study is presented in the prestigious journal Cell.
Cornell researchers identify a weak link in cancer cell armor
The seeming invincibility of cancerous tumors may be crumbling, thanks to a promising new gene therapy that eliminates the ability of certain cells to repair themselves.
Aileron collaborates study in Nature: Stapled peptides inhibit Notch1 transcription factor
This research validates the potential for Stapled Peptides to modulate key intracellular biological targets, such as transcription factors, that have not been addressable with current small molecule or biologic drug modalities.
Researchers 'notch' a victory toward new kind of cancer drug
Scientists have devised an innovative way to disarm a key protein considered to be "undruggable," meaning that all previous efforts to develop a drug against it have failed.
Barrow study identifies new way to biopsy brain tumors in real time
A new miniature, hand-held microscope may allow more precise removal of brain tumors and an easier recognition of tumor locations during surgery.
Coffee break: Compound brewing new research in colon, breast cancer
A compound in coffee has been found to be estrogenic in studies by Texas AgriLife Research scientists.
Newly Discovered Fat Molecule: An Undersea Killer with an Upside
A chemical culprit responsible for the rapid, mysterious death of phytoplankton in the North Atlantic Ocean has been found by collaborating scientists at Rutgers University and the Woods Hole Oceanographic Institution (WHOI). This same chemical may hold unexpected promise in cancer research.
More Cancer Cells Current Events and Cancer Cells News Articles
 |
One Renegade Cell: The Quest For The Origin Of Cancer (Science Masters) by Robert A. Weinberg (Author) For everyone whose life has been touched by cancer, One Renegade Cell tells the story of the search for the ultimate causes of this dreaded disease. "One Renegade Cell…offers a breathtaking picture, both wonderful and frightening, of the fantastic intricacy of aberrant cellular functioning." -New York Times "Part primer, part history and part meditation. [One Renegade Cell] succeeds on all counts." -Wall Street Journal One of the leading cancer researchers in the world, Robert A. Weinberg is perfectly suited to describe the search for cancer's origins from the early days of this century to the present. Presuming little knowledge of biology, he tells how a cancer-causing virus was first discovered in 1909, how the correlation was made between chemical ... |
 |
Destroying Cancer Cells Using Your Subconscious Mind a Guided Imagery and Subliminal program Starring: Steve Murray Directed By: Steve Murray The DVD has two separate "Destroying Cancer Cells" self-help programs: A Guided Imagery and a Subliminal program. Both have easy-to-follow directions and can be used before, during, and after cancer treatments. Guided Imagery is the language of the mind. It is a way of communicating with parts of the body that cannot speak in words. You will learn this language in the DVD. Research has shown Guided Imagery is a powerful self-help tool. The Guided Imagery program starts with a relaxation technique, then guides you through ten imagery segments. Subliminal Messages have been used for years by advertisers to reprogram and change one s subconscious mind about their products. With this DVD, you will use Subliminal Message s for your benefit. During the subliminal program all you have to do is... |
 |
Breast Cancer Awareness Cell Phone Case - Pink by Vertik Breast Cancer Awareness Cell Phone Case - Pink Pink Ribbon Embossed Vertik Universal Case. Constructed of Durable Impact resistant material. Fits These Model Numbers: Audiovox CDM-8500, CDM-8600, CDM-8615, CDM-8900, CDM-8910, Flasher_V7, PM-8920, Vox_8610, Kyocera 5135, KX1_SoHo, KX1v, S-14_OPAL, LG 1010, C1300, C1300i, C1500, C2000, G4010_G4011, G4015, G4050, L1150, L1200, L1400, L1400i, LX1200, VI125, VX 1, VX 10, VX3100, VX3100L, VX3200, VX4400, VX4500, VX4600, VX6000, VX6100, Motorola A840, E310, E815, T720c, T720i, T721, T722i, T725e, T730, T731c, V170, V173, V180, V186, V188, V190, V220, V260, V262, V265, V266, V276, V300, V330, V360, V400, V505, V540, V551, V555, V557, V600, V60c, V60g, V60i, V60t, V60ti, V60v, V60x, V66, V710, V810, Nokia 3155i, 6101, 6102, 6255i, 6256i,... |
 |
Cancer Research / Testing Cells Directed By: Rex Barnett |
|
Cancer and the Immune System : Cell-to-Cell Communication, An Introduction (31 minute colour VHS video) (NTSC video) by Spektrum Videothek Produced in Germany. In English. "This documentary focuses on... findings in immunilogical research." | |
 |
Cell Phone Strap - Breast Cancer Support Pink Ribbon - 8" by Trutex |
![Dissolving & Destroying Cancer Cells "A Guided Imagery Program" [VHS]](http://ecx.images-amazon.com/images/I/41JQAV3VE9L._SL160_.jpg) |
Dissolving & Destroying Cancer Cells "A Guided Imagery Program" [VHS] Also With: steve murray (Primary Contributor) Steve Murray the author of "Cancer Guided Imagery Program for Radiation, Chemotherapy, Surgery and Recovery" now has a series of DVDs and Videos that will help you: Tap into the Healing Power of the Body and Mind Connection This program when used in conjunction with your prescribed medical treatment shows you how to do just that. With easy to understand explanations and directions, you will be able to start a Cancer Guided Imagery Program right away. Guided Imagery is the language of the mind. It is a way of communicating with parts of ourselves that cannot speak in words. You will use this language in the program. Program Includes: -Directions on how to do program-Guided relaxation and ten Cancer Guided Imagery segments-Soothing music, calm peaceful images- Verbal and... |
 |
Fight Against Kidney (Renal Cell) Cancer Sweatshirt XX-Large White by Shop Zeus |
 |
Antioxidant + Resveratrol , (60 Capltes/bottle) This product provides nutritional support to defend against the effects of free radicals. Resveratrol is a type of polyphenol called a phytoalexin. Resvertraol works by binding to a class of proteins called sirtuins, which regulate the enzymes that can stimulate cancer-cell growth and suppress immune response. Resveratrol may also have powerful and diverse effects on the heart and blood vessels. by Vitamore Free-radicals (also called oxidants) are highly unstable molecules that can damage cell membranes. This may start a process that leads to several chronic diseases and may be involved with many aspects of aging. Free radicals are produced in the body during normal cell metabolism, and may also be caused by other environmental and lifestyle factors such as stress, smoking, polution, etc. This product provides nutritional support to defend against the effects of free radicals using the antioxidant vitamins of C and E and the trace elements of Zinc and Selenium. The key ingredient is the flavonoid-rich Resveratrol. Resveratrol is a type of polyphenol called a phytoalexin. Resvertraol works by binding to a class of proteins called sirtuins, which regulate the enzymes that can stimulate... |
 |
Beating Non-Small Cell Lung Cancer Together Keychain by Design a Product LLC Text on keychain: Beating Non-Small Cell Lung Cancer Together * Durable acrylic key chain is crystal-clear and double-sided so the artwork or message is seen twice. * Sturdy metal ring holds your keys securely. * Full color printed images or messages are included. * If you have new ideas or need help selecting text for your custom keychains please contact us. * Size: 2 1/8" x 3 1/2" (Approx. business card) |
| © 2009 BrightSurf.com |