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tTGA: Is it more essential in diagnosis of gluten sensitive enteropathy?
March 24, 2009CD is a highly prevalent disease (1:100 to 1:300) which fulfils most of the criteria favoring mass screening. Despite this, screening for gluten sensitive enteropathy (GSE) is still controversial due to its dubious benefits and the acceptance of a gluten-free diet (GFD).
A research article to be published on March 21, 2009 in the World Journal of Gastroenterology address this question. The study shows that GSE patients in the general population may not be identified by clinical features, since a similar percentage of related CD symptoms was found in individuals with positive and negative markers. This fact explains why CD remains underdiagnosed in a high proportion of affected subjects and is an additional argument for mass-screening using other approaches. It was also demonstarted that Marsh I subjects detected by t-TGA evaluation in a non-at-risk group for CD, were as symptomathic as Marsh III patients and also responded to GFD, reinforcing the final diagnosis of GSE in mild enteropathy.
GSE in the general population is frequent and is clinically relevant, irrespective of the severity of the histological lesions. Mass screening programs are useful to identify these patients in order to initiate either a GFD or close follow-up monitoring. t-TG antibody is more sensitive than EmA for the diagnosis of the whole spectrum of GSE in the general population.
The authors of the paper work in a tertiary hospital and individuals were recruited from an Occupational Health Department.
World Journal of Gastroenterology
The authors of the paper work in a tertiary hospital and individuals were recruited from an Occupational Health Department.
World Journal of Gastroenterology
The prevalence of gluten-sensitive enteropathy in iron-deficient anemia patients
Gluten sensitive enteropathy (GSE) is an autoimmune enteropathy due to food gluten intolerance in genetically predisposed people.
A rare case of collagenous colitis presenting as protein-losing enteropathy
Since the first report in 1976, collagenous colitis has been associated with a variety of conditions, including use of non-steroidal anti-inflammatory drugs and proton pump inhibitors.
Researchers identify gene responsible for rare childhood disease
The chromosomal abnormality that causes a rare, but often fatal, disorder that affects infants has been identified by researchers at the University of California, San Diego School of Medicine, who happened to treat two young children with the disease in San Diego - two of perhaps a dozen children in the entire country diagnosed with the disorder.
Potentially Safe and Effective Therapy Revealed for Patients with Protein-Losing Enteropathy
Researchers at the Burnham Institute for Medical Research (Burnham Institute) have developed the first model to study intestinal protein leakage in mice, allowing the team to control and replicate both genetic deficiencies and environmental damages in an in vivo setting.
Cocktails ameliorate celiac disease
The University Rovira i Virgili (Spain), the company Trace Biotech AG (Braunschweig), the Institut für Mikrotechnik Mainz GmbH (IMM, Mainz), and seven other European partners are jointly developing a biosensor for the detection of gluten in food. The goal of the ambitious project is to manufacture a disposable microsystem with integrated modules for a standardised extraction and analysis of gluten in food samples. The system, for the first time, will permit patients suffering from celiac disease (gluten sensitive enteropathy) to conduct an on-the-spot analysis of fresh, cooked, or industrially processed food with the aid of a screening procedure. The project is funded with more than 3 M
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Enteropathies: Webster's Facts and Phrases by Icon Group International (Author) Ever need a fact or quotation on "enteropathies"? Designed for speechwriters, journalists, writers, researchers, students, professors, teachers, historians, academics, scrapbookers, trivia buffs and word lovers, this is the largest book ever created for this word. It represents a compilation of "single sentences" and/or "short paragraphs" from a variety of sources with a linguistic emphasis on anything relating to the term "enteropathies," including non-conventional usage and alternative meanings which capture ambiguities. This is not an encyclopedic book, but rather a collage of statements made using the word "enteropathies," or related words (e.g. inflections, synonyms or antonyms). This title is one of a series of books that considers all major vocabulary words. The entries in each... |
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