Increase in p53 mutation linked to advanced colorectal cancer in blacks

April 01, 2009

PHILADELPHIA - Researchers have identified a possible genetic cause for increased risk for a more advanced form of colorectal cancer in blacks that leads to shorter survival, according to data published in Clinical Cancer Research, a journal of the American Association for Cancer Research.

Understanding the relationship between molecular defects and differences in colorectal cancer incidence, aggressiveness and clinical outcomes is important in individualizing the treatment and in eliminating racial disparities.

"Several studies have identified a disparity between African-Americans and whites for colorectal cancer. What this study does is pinpoint a possible genetic cause," said Upender Manne, Ph.D., associate professor in the Department of Pathology at the University of Alabama at Birmingham.

For the current study, Manne and colleagues analyzed 137 colorectal adenocarcinomas from African-American patients and 236 colorectal adenocarcinomas from non-Hispanic whites. Researchers assessed these carcinomas for p53 mutations and genotyped for codon 72 polymorphisms.

Overall, whites and African-Americans had a similar rate of p53 mutations. However, the frequency of the Pro72 allele was higher in blacks at 17 percent compared with 7 percent among whites. By contrast, the Arg72 allele frequency was higher in whites at 36 percent than in African-Americans, where the frequency was 19 percent.

Presence of the Pro72 allele in blacks was associated with a more than two-fold increase in mortality due to colorectal cancer.

"This paper shows that in a subset of patients with the Pro72 allele, and the susceptibility to p53 mutations may be a possible molecular explanation for the racial disparity," said Manne.

American Association for Cancer Research

---

---

	American Cancer Society's Complete Guide to Colorectal Cancer by American Cancer Society (Author), Bernard Levin (Editor), Terri Ades (Editor), Katie Couric (Editor) Created by a prestigious panel of experts, this new book offers comprehensive coverage of colorectal cancer, the second most prevalent form of cancer in the world, which, with proper screening, is almost entirely preventable. It provides up-to-date, essential information about the disease, including prevention, detection, diagnosis, treatment options, complementary and alternative therapies, coping, living well with cancer, caregiving, and much more. Throughout the text real cancer survivors offer their experience dealing with this disease, from diagnosis to treatment and beyond.
	ABC of Colorectal Cancer (ABC Series) by Annie Young (Editor), Richard Hobbs (Editor), David Kerr (Editor) Colorectal cancer is a common cause of morbidity and mortality in which prevention, screening and early detection are vital. Beginning with the patient perspective and following the patient pathway, this new second edition covers epidemiology and prevention, screening programmes, decision support networks, the role of primary care, and supportive care for patients with colorectal cancer.The ABC of Colorectal Cancer provides the core knowledge on clinical genetics, diagnosis, imaging, therapy and surgery options and the latest evidence based guidelines for treating and managing colorectal cancer patients within the multidisciplinary team. Highly illustrated and accessible, it covers the full spectrum of the disease to provide the basis to make a real difference to clinical management.This...
	Be a Survivor Colorectal Cancer Treatment Guide by Vladimir Lange (Author) Dr. Lange’s comprehensive overview of cancer and treatment options offers detailed information using simple, concise language and a wide variety of color photos and drawings. Colorectal cancer patients need to know more about their disease, yet there is an overload of information. Be a Survivor gives the patient the specific, reliable and necessary information to make good decisions about their cancer and treatment options. Annually, 150,000 Americans are told they have colorectal cancer, making it one of the top three most common cancers in the United States. Diagnosed early, colorectal cancer is treatable, often curable, and vey preventable. This resource covers all aspects of colorectal cancer—from diagnosis to recovery, including a chapter for the patient's spouse.
	What Your Doctor May Not Tell You About(TM) Colorectal Cancer: New Tests, New Treatments, New Hope by Mark Bennett Pochapin (Author) - What Your Doctor May Not Tell You About Colorectal Cancer was published in Warner hardcover (0-446-53188-X) in 3/04. The book features a foreword by Katie Couric. - Dr. Pochapin made an appearance on the Today show in conjunction with the hardcover publication of this book. Previously, he had been chosen by Katie Couric to be the Medical Director of the Jay Monahan Center for Gastrointestinal Health, named in honor of Ms. Couric's late husband. - The author is an associate professor of clinical medicine at the Weill Medical College of Cornell University and Chief of Gastrointestinal Endoscopy at New York Presbyterian Hospital's Weill Cornell Medical Center. - There are approximately 100,000 new colorectal cancer cases diagnosed annually, making it the second leading cause of...
	Positive Options for Colorectal Cancer: Self-Help and Treatment by Carol Ann Larson (Author), Kathleen Ogle (Foreword) Colorectal cancer develops slowly over a period of several years, undetected, usually as polyps. It is a preventable and treatable disease if caught in time, yet most know little about how to read its symptoms. Written for the layperson, this book covers all the uncomfortable questions and answers about the disease, from prevention and warning signs, to screening and diagnosis techniques, to making decisions and developing treatment plans. Also included are positive stories about life after cancer by 12 survivors.
	COPING WITH COLORECTAL CANCER by Crystal Night Books DESCRIPTION: Coping With Colorectal Cancer – the prevention and cure of the second leading cause of cancer deaths is dedicated to helping reduce the toll this disease takes on human lives. It aims at prevention by teaching people to avoid the risk factors that lead to the disease, to save lives through leading victims to early detection, and presenting treatment options to those patients diagnosed with the disease. Colorectal cancer, also commonly called bowel cancer, is caused by uncontrolled cell growth in the colon, rectum, or appendix. Actually the majority colorectal cancers occurs due to lifestyle and increasing age, while a minority of cases are associated with underlying genetic disorders. Colorectal cancer typically starts in the lining of the bowel and...
	American Cancer Society Complete Guide to Nutrition for Cancer Survivors: Eating Well, Staying Well During and After Cancer by Abby S. Bloch PhD RD (Editor), Barbara Grant MS RD CSO LD (Editor), Kathryn K. Hamilton MA RD CDN CSO (Editor), Cynthia A. Thomson PhD RD (Editor) Written for consumers, patients, and families seeking reliable information about nutritional support for people with cancer, this comprehensive guide offers the latest information about using nutrition to optimal advantage during the cancer journey. Also discussed is the role of sound nutritional choices before, during, and after cancer therapy and how they can help bolster energy levels, strengthen the immune system, fight off infection, and minimize the side effects of treatment. Charts, information on special diets, and level-headed advice about dietary supplements make this a valuable tool for maintaining a healthy lifestyle.
	Colorectal Cancer: Evidence-based Chemotherapy Strategies (Current Clinical Oncology) by Leonard B. Saltz (Editor) Recent advances in the understanding of the biology of colorectal cancer have radically transformed the treatment options available to clinicians, leaving textbooks written only two years ago completely out of date. This evidence-based and data-driven guide presents reviews of cutting-edge therapies for colorectal cancer, all articulated by leading experts in the field. This integrated and focused consideration of colorectal management includes reviews of cytotoxic chemotherapy, targeted biologic therapies, as well as updates on adjuvant chemotherapy for colon cancer and combined modality management of rectal cancers. Attention is also focussed on the role of potentially curative multi-modality management of liver metastases, with considerations of the role of liver resection and...
	100 Questions & Answers About Colorectal Cancer by David Bub (Author), Susannah L. Rose (Author), W. Douglas Wong (Author) Whether You’Re A Newly Diagnosed Cancer Patient, A Survivor, Or A Friend Or Relative Of Either, This Book Offers Help. The Only Text To Provide The Doctor’S And Patient’S View, The Second Edition Is Updated With Authoritative, Practical Answers To Your Questions About Treatment Options, Post-Treatment Quality Of Life, Sources Of Support, And Much More. This Book Is An Invaluable Resource For Anyone Coping With The Physical And Emotional Turmoil Of This Frightening Disease. The Authors Consist Of Two Oncologic Surgeons And A Cancer Care Social Worker From Memorial Sloan-Kettering Cancer Center. Commentary From Actual Colon And Rectal Cancer Survivors Provides A Unique, “Insider’S” Perspective.
	Brush sampling screen preferred for colorectal ca: patient friendly.(cancer)(Gastroenterology): An article from: Internal Medicine News by Sharon Worcester (Author) This digital document is an article from Internal Medicine News, published by International Medical News Group on September 1, 2003. The length of the article is 597 words. The page length shown above is based on a typical 300-word page. The article is delivered in HTML format and is available in your Amazon.com Digital Locker immediately after purchase. You can view it with any web browser. Citation Details Title: Brush sampling screen preferred for colorectal ca: patient friendly.(cancer)(Gastroenterology) Author: Sharon Worcester Publication: Internal Medicine News (Magazine/Journal) Date: September 1, 2003 Publisher: International Medical News Group Volume: 36 Issue: 17 Page: 45(1) Distributed by Thomson...