The More Oral Bacteria, the Higher the Risk of Heart Attack, UB study shows.

April 01, 2009

BUFFALO, N.Y. -- Several studies have suggested there is a connection between organisms that cause gum disease, known scientifically as periodontal disease, and the development of heart disease, but few studies have tested this theory.

A study conducted at the University at Buffalo, where the gum disease/heart disease connection was uncovered, now has shown that two oral pathogens in the mouth were associated with an increased risk of having a heart attack, but that the total number of germs, regardless of type, was more important to heart health.

Results of the study will be presented during a poster session at the International Association of Dental Research (IADR) General Session being held in Miami, Fla., from April 1-4.

Oelisoa M. Andriankaja, D.D.S., Ph.D., conducted the study in UB's Department of Oral Biology in the School of Dental Medicine, as a postdoctoral researcher. She currently is an adjunct professor at the University of Puerto Rico's School of Dental Medicine.

"The message here," said Andriankaja, "is that even though some specific periodontal pathogens have been found to be associated with an increased risk of coronary heart disease, the total bacterial pathogenic burden is more important than the type of bacteria.

"In other words, the total number of 'bugs' is more important than one single organism," she said.

The study involved 386 men and women between the ages of 35 and 69 who had suffered a heart attack and 840 people free of heart trouble who served as controls. Samples of dental plaque, where germs adhere, were collected from 12 sites in the gums of all participants.

The samples were analyzed for the presence of the six common types of periodontal bacteria, as well as the total number of bacteria.

The patients harbored more of each type of bacteria than the controls, the analysis showed. However, only two species, known as Tannerella Forsynthesis and Preventella Intermedia, had a statistically significant association with an increased risk of heart attack.

An increase in the number of different periodontal bacteria also increased the odds of having a heart attack, results showed.

Prospective studies -- those that measure oral bacteria in participants who have had no heart problems when they enter the study, and again when a heart attack occurs in a participant -- are needed to better assess this potential association, noted Andriankaja.

Additional researchers on the study from UB were Karen L. Falkner, Ph.D., Robert J. Genco, D.D.S., Ph.D., Sreenivasa Sarikonda, a doctoral candidate, Joan Dorn, Ph.D., and Kathleen Hovey, M.S.

Tania Mendoza, D.D.S., from the University of North Carolina at Chapel Hill, and Maurizio Trevisan, M.D., M.S., former dean of the UB School of Public Health and Health Professions, now vice chancellor and chief executive officer of the University of Nevada Health Sciences System, also contributed to the study.

The study was funded by the National Institute of Dental and Craniofacial Research (NIDCR).

The University at Buffalo is a premier research-intensive public university, a flagship institution in the State University of New York system and its largest and most comprehensive campus. The School of Dental Medicine is one of five schools that constitute UB's Academic Health Center. UB's more than 28,000 students pursue their academic interests through more than 300 undergraduate, graduate and professional degree programs. Founded in 1846, the University at Buffalo is a member of the Association of American Universities.

The University at Buffalo

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