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Researchers find current drug can treat rare heart disorder
April 02, 2009New research has found that the answer to treating a rare inherited heart disorder could lie with a drug already on the market.
Associate Professor Derek Laver from the University of Newcastle and international colleagues have found that Flecainide - a drug used to treat heart arrhythmias - could also be used to treat Catecholaminergic Polymorphic Ventricular Tachycardia (CPVT).
CVPT is a heart arrhythmia induced by emotional stress or exercise. It is estimated to cause 15 per cent of all unexplained sudden cardiac deaths in people under the age of 30.
Associate Professor Laver said CPVT was caused by too much calcium being released from calcium stores within the heart cells.
"Correct calcium flow within the heart cells is essential for the heart to function properly," he explained. "Calcium is released from the stores into the heart cells through specific channels and we have found that Flecainide reduces the ability of these channels to release calcium, thereby directly counteracting the cause of CPVT."
Currently, beta-blockers are used to treat CPVT but 37 per cent of patients are unresponsive and 24 per cent suffer sudden cardiac death within 10 years of beginning treatment.
Implantable defibrillators are used to prevent sudden death but these cause painful electric shocks that can trigger further stress-induced arrhythmias.
"Current treatments are largely ineffective and we need new and more effective anti-arrhythmic drugs," Associate Professor Laver said.
"We have now discovered something close to an ideal drug for this rare arrhythmia disorder."
Research Australia
Associate Professor Laver said CPVT was caused by too much calcium being released from calcium stores within the heart cells.
"Correct calcium flow within the heart cells is essential for the heart to function properly," he explained. "Calcium is released from the stores into the heart cells through specific channels and we have found that Flecainide reduces the ability of these channels to release calcium, thereby directly counteracting the cause of CPVT."
Currently, beta-blockers are used to treat CPVT but 37 per cent of patients are unresponsive and 24 per cent suffer sudden cardiac death within 10 years of beginning treatment.
Implantable defibrillators are used to prevent sudden death but these cause painful electric shocks that can trigger further stress-induced arrhythmias.
"Current treatments are largely ineffective and we need new and more effective anti-arrhythmic drugs," Associate Professor Laver said.
"We have now discovered something close to an ideal drug for this rare arrhythmia disorder."
Research Australia
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Selenium supplementation, for example in mineral tablets, might not be that beneficial for the majority of people according to researchers writing in the open access journal Genome Biology.
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Overactivation of two receptors for histamine, normally associated with common allergies and acid reflux, may explain why some people, including highly trained athletes, pass out soon after heightened physical activities.
Competitive athletes not over-represented in sudden cardiac death
Sudden cardiac death among young people is uncommon but is not decreasing. Three times more men than women are affected, and competitive athletes are not over-represented. This is shown a dissertation written by Aase Wisten, Ume'å University, to be publicly defended in the auditorium at Sunderby Hospital on May 25.
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