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Can periodontal disease act as a risk factor for HIV-1?
April 03, 2009Today, during the 87th General Session of the International Association for Dental Research, convening at the Miami Beach Convention Center, a group of scientists from Nihon University (Tokyo, Japan) will present findings suggesting that periodontal disease could act as a risk factor for reactivating latent HIV-1 in affected individuals.
Latently infected cells harbor HIV-1 proviral DNA genomes integrated with heterochromatins, allowing for the persistence of transcriptionally silent proviruses. Hypoacetylation of histone proteins by histone deacetylases (HDACs) is primarily involved in the maintenance of HIV-1 latency by repressing transcription from HIV-1 provirus. On the other hand, periodontal diseases, caused by infection with the bacterium Porphyromonas gingivalis (P. gingivalis), are found worldwide and are among the most prevalent microbial diseases of mankind.
The investigators demonstrated the effects of such periodontopathic bacteria on HIV-1 replication. They found that P. gingivalis could strongly facilitate HIV-1 reactivation via chromatin modification. The bacteria produced high concentrations of butyric acid, a potent inhibitor of HDACs, and induced acetylation of histones, leading to reactivation of HIV-1 in latently infected cells. These results suggest that periodontal disease could act as a risk-factor for HIV-1 reactivation in latently infected individuals, and might contribute to the systemic dissemination of the virus causing clinical progression of acquired immunodeficiency syndrome (AIDS). The findings emphasize the essential role of maintaining oral hygiene and controlling oral diseases for the prevention of AIDS.
International & American Association for Dental Research
International & American Association for Dental Research
Periodontal Disease Current Events and Periodontal Disease News RSSAAP supports the IDF guideline on oral health for people with diabetes
New clinical guidelines released by the International Diabetes Foundation (IDF) emphasize the importance of periodontal health for people with diabetes.
Body's immune system response to dental plaque varies by gender and race
Will neglecting to brush your teeth damage more than just your smile? Can failing to attack dental plaque increase your risk of heart damage?
AADR releases its statement on oral health care within health care reform
On July 14, the American Association for Dental Research released its policy statement titled "Oral Health Care within Health Care Reform," which focuses on the scientific base of oral health and its associations to other aspects of health.
Oral/Body Inflammatory Connection Explained
Is your head where your heart is? It may be now. A strong connection between periodontal disease and cardiovascular disease (CVD) has been suggested in recent clinical studies.
Is obesity an oral bacterial disease?
The world-wide explosion of overweight people has been called an epidemic. The inflammatory nature of obesity is widely recognized.
Over half of people with rheumatoid arthritis have periodontitis
Over half (56%) of people with rheumatoid arthritis (RA) also have periodontitis (a chronic inflammatory disease of the gum and surrounding ligaments and bones that hold the teeth in place), displaying fewer teeth than healthy matched controls, high prevalence of oral sites presenting dental plaque and advanced attachment loss (the extent of periodontal support that has been destroyed around a tooth) (chi square p<0.05).
Treating gum disease helps rheumatoid arthritis sufferers
People, who suffer from gum disease and also have a severe form of rheumatoid arthritis, reduced their arthritic pain, number of swollen joints and the degree of morning stiffness when they cured their dental problems.
Is vitamin D deficiency linked to Alzheimer's disease and vascular dementia?
There are several risk factors for the development of Alzheimer's disease and vascular dementia. Based on an increasing number of studies linking these risk factors with Vitamin D deficiency.
Examining TLR4 influences of B cell response
Chronic inflammation, which is at the root of multiple diseases, links periodontal disease to increased incidence of cardiovascular disease.
Prostate cancer therapy increases risk of fractures and cardiovascular-related death
Prostate cancer patients who undergo therapy to decrease testosterone levels increase their risk of developing bone- and heart-related side effects compared to patients who do not take these medications, according to a new analysis.
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Reversing Gum Disease Naturally: A Holistic Home Care Program by Sandra Senzon (Author) "Reversing Gum Disease Naturally presents techniques and information so that you can reverse already unhealthy states in your mouth or prevent the onset of gum disease. Sandra Senzon enhances patients’ oral health through traditional as well as holistic methods." ––Barry Musikant, D.M.D. "This book allows the patient to be an active participant along with healthcare professionals." "There is a ray of hope at the end of the tunnel for all those who suffer from gum disease. We ultimately don’t have to lose our natural teeth. Sandra Senzon shows us the many ways in which the mouth is connected to the body, and how, with the use of natural herbal products and proper mechanic techniques, you can reverse gum disease... |
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Nature's Smile End Gum Disease by Nature's Smile You already now that this product that has stopped gum disease for millions of people around the world. Now available here. Nature's Smile is the only real cure for gum and periodontal disease anywhere. Heres how Natures SmileTM formula works in action..." Every time you use Natures SmileTM its active ingredients start to attack the germs that are attacking the bone that holds your teeth in your mouth. All the ingredients in Natures SmileTM are specially combined to fight this fight for you. Your body is either unable or unwilling to do it for you. Once the natural extracts get inside your gums, these germs are no match. Natures SmileTM continues to work all day and night. Within weeks you will see for yourself that you are winning the fight against gum disease and gingivitis. The... |
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Dr. Katz Perio Therapy The Complete Gum Care System for Superior Oral Hygiene , 1 Kit by Dr. Harold Katz Maximum strength clinical formula. Free Dr. Katz's Oral Health Secrets booklet inside. Contents: One 500 ml bottle PerioTherapy Rinse; One Measuring Cup; One 100 ml tube of PerioTherapy Gel/Toothpaste; Two moldable treatment trays; 6 Sachets of TheraFloss dental floss; and Dr. Katz's Oral Health Secrets Booklet. Good health starts in the mouth! I developed this advanced system for my family and patients to use at home. I believe it is the best oral care formula available today. The concentrated PeriO2 & ZincRx formula. Invigorating natural minty taste. Our highest level of CoQ10, aloe vera, tea tree oil, and Xylitol. No messy mixing. No SLS. No saccharin. No alcohol. No artificial flavors or colors. Concentrated PeriO2 provides healthy oxygen to damaged gum tissue and attacks nasty... |
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C.E.T. Duel-End Toothbrush, Fingerbrush & Enzymatic Toothpaste Oral Hygiene Kit by 3M Animal Care Products Pets Have Teeth Too Home dental care is as important for your pet as it is for you. Periodontal disease affects 85% of adult dogs and cats and can lead to pain, bad breath and tooth loss. Even worse, chronic oral infection can spread harmful bacteria to other parts of the body, including the lungs, heart, liver, and kidneys. Fortunately most periodontal disease is preventable through a program of oral hygiene and regular professional care. Routine home dental care should be a part of every pet's preventive medicine program. |
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CoMal Q10, 90 Capsules by Nutramax Laboratories CoMal Q10 is a safe and natural supplement of CoEnzyme Q10, a necessary enzyme involved in cardiovascular and periodontal function. Supplementation promotes gum tissue health, improves carbohydrate metabolism and increases the cellular energy necessary for proper heart function and health. This supplement is recommended for dogs and cats with immune deficiency disorders, cardiac disease and heart murmurs, as well as those with periodontal and gum disease. |
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Periactil Gel and Precondition Kit - EXTREME Cavity Fighting and Gum Disease Reversal and Prevention by Distributed by medACTIL, Ltda. Periactil Gel and Precondition carry xylitol in a proprietary and special manner, allowing it to adhere to teeth and gums. This is the most advanced method for delivery and utilization of xylitol as a tooth and gum protective agent and offers far more protection than xylitol toothpastes. Small cavities are inhibited from growing; the formation of new cavities is dramatically reduced; gum disease is reversed and prevented. Gums are strengthened. Soothes mouth sores. Reduces swelling. Promotes rapid healing and pain reduction after dental treatment. Excerpt from and according to the California Dental Association, "Xylitol inhibits the growth of the bacteria that cause cavities. It does this because these bacteria (Streptococcus mutans) cannot utilize xylitol to grow. Over time with... |
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Minimally Invasive Treatment, Arrest, and Control of Periodontal Diseases (The Axelsson Series on Preventive Dentistry) by Per Axelsson (Author) This well-illustrated book, the fifth volume in the Axelsson Series on Preventive Dentistry, applies the concepts presented in the previous volumes to clinical practice in a step-by-step fashion. With a focus on minimally invasive treatment, the principles covered in this book ensure long-term treatment success and prevention of periodontal diseases. Specific topics covered include minimally invasive scaling, root planing, and debridement; healing of infectious inflamed periodontal tissues; repair and regeneration of lost periodontal tissues; and needs-related periodontal preventive and maintenance care. While the previous volumes were conceptualized with students and teachers in mind, this book will be an indispensable guide for general practitioners and dental hygienists as well. |
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MicroLite Baby Periosteal Elevators Fine Blades Double Ended by Medco Instruments Uniquely designed and lightweight for easy tooth extraction on children. |
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Biotene Veterinarian Antiseptic Oral Gel 1 oz by Laclede Biotene Veterinarian Antiseptic Oral Gel contains a potent enzyme formula to aid in the treatment of severe oral infections such as stomatitis, gingivitis and periodontal disease. The Three Point Enzyme System used in this product has been shown to be antifungal, antibacterial and antiviral. |
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