 |
|
GEN highlights increasing use of digital gene expression profiling
April 06, 2009A novel technique for carrying out gene-expression profiling is set to challenge the market dominance of the current, widely used methodology, reports Genetic Engineering & Biotechnology News (GEN). Some scientists believe that digital gene-expression profiling, a fully quantitative approach for gene-expression analysis, will eventually rival microarrays in this application area, according to the April 1 issue of GEN (http://www.genengnews.com/articles/chitem.aspx?aid=2844).
"Digital gene expression technologies are certainly catching the attention of the life science research community," says John Sterling, Editor in Chief of GEN. "The approach looks to be especially appealing to those working in the area of transcriptomics.
A group of Dutch researchers compared deep sequencing-based gene-expression analysis using the Illumina whole genome sequencer to five microarray-based platforms. They concluded that deep sequencing provides a major advance in robustness, comparability, and richness of expression profiling data. The scientists predict that with the continuously increasing number of reads at reduced costs, RNASeq, a.k.a. whole transcriptome shotgun sequencing, will become affordable for standard differential gene-expression analysis.
DNAStar recently introduced QSeq, the first product to use the company's disk sort alignment algorithm for quantitative RNASeq applications and digital gene-expression experiments. DNAStar officials view RNASeq as being is in the validation stage.
Mary Ann Liebert, Inc./Genetic Engineering News
DNAStar recently introduced QSeq, the first product to use the company's disk sort alignment algorithm for quantitative RNASeq applications and digital gene-expression experiments. DNAStar officials view RNASeq as being is in the validation stage.
Mary Ann Liebert, Inc./Genetic Engineering News
Gene-expression Current Events and Gene-expression News RSSWill IVF work for a particular patient? The answer may be found in her blood
For the first time, researchers have been able to identify genetic predictors of the potential success or failure of IVF treatment in blood.
U of I study: Fructose metabolism more complicated than was thought
A new University of Illinois study suggests that we may pay a price for ingesting too much fructose. According to lead author Manabu Nakamura, dietary fructose affects a wide range of genes in the liver that had not previously been identified.
Type-1 diabetes not so much bad genes as good genes behaving badly, Stanford research shows
Investigators combing the genome in the hope of finding genetic variants responsible for triggering early-onset diabetes may be looking in the wrong place, new research at the Stanford University School of Medicine suggests.
New Electrostatic-based DNA Microarray Technique Could Revolutionize Medical Diagnostics
The dream of personalized medicine - in which diagnostics, risk predictions and treatment decisions are based on a patient's genetic profile - may be on the verge of being expanded beyond the wealthiest of nations with state-of-the-art clinics.
Gene-expression profiling of the effects of liver toxins
Gene-expression data from liver tissue or whole blood can be used to classify histopathologic differences in the effects of hepatotoxins. It is hoped that these findings, published in BioMed Central's open access journal, Genome Biology, will lead to a more precise way of defining the potential hepatotoxicity of new compounds.
How advanced prostate cancer becomes resistant to androgen-deprivation therapy
For the past 70 years the treatment of choice for advanced, metastatic prostate cancer has been androgen-deprivation therapy.
Estrogen Helps Drive Distinct, Aggressive Form of Prostate Cancer
Using a breakthrough technology, researchers led by a Weill Cornell Medical College scientist have pinpointed the hormone estrogen as a key player in about half of all prostate cancers.
Molecular science could further improve leukemia survival, say St. Jude researchers
The dramatic increase that has occurred in the cure rate for children with acute lymphoblastic leukemia (ALL) will be difficult to replicate in older patients without considerable additional research.
Immune cells fighting chronic infections become progressively 'exhausted,' ineffective
A new study of immune cells battling a chronic viral infection shows that the cells, called T cells, become exhausted by the fight in specific ways, undergoing profound changes that make them progressively less effective over time.
New genetic marker characterizes aggressiveness of cancer cells
Levels of a small non-coding RNA molecule called let-7 appear to define different stages of cancer better than some of the "classical" markers for tumor progression.
More Gene-expression Current Events and Gene-expression News Articles
 |
Regulation of Gene Expression by Gary H. Perdew (Author), Jack P. Vanden Heuvel (Author), Jeffrey M. Peters (Author) Regulation of Gene Expression: Molecular Mechanisms presents a comprehensive overview of methods and approaches for characterizing mechanisms of gene regulation. The text is appropriate both as a graduate textbook and a standard laboratory reference and provides the essential groundwork for an advanced understanding of the various mechanisms that may result in altered activity of a specific cell protein. Each of three sections explores mechanisms of gene regulation and expression, and presents methods and protocols for achieving specific experimental goals. Part I focuses on approaches for studying control of mRNA expression and determining target genes for a given transcription copy. Part II outlines the methods for determining how proteins can regulate each other by mediating... |
 |
Gene Expression and Regulation by Jun Ma (Author) This book offers a comprehensive look into the science of gene expression and regulation. Focusing on topics such as actions of nuclear receptors, RNA processing, and DNA methylation and imprinting, "Gene Expression and Regulation" is edited by a leading biologist and includes contributions by experts in the field. Presented in the following five sections, this book covers a full spectrum of topics: The History; The Machinery; The Regulators; The Genome; and Special Topics. The Machinery section covers the transcriptional apparatus and general transcription factors. The Regulators section examines selected gene-specific transcription factors important to regulating gene expression. The Genome section covers issues relevant to the behavior of the genome in relation to gene regulation. The... |
 |
The Psychobiology of Gene Expression by Ernest L. Rossi (Author) Outlines the relationship between genes and human experience. The understandings of gene expression emerging from the Human Genome Project are setting the stage for a profound expansion of our understanding of life. We are just now beginning to learn how the brain, body, and genes interact in everyday life. Here, Ernest Rossi introduces the new science of psychosocial genomics and explores how it will profoundly change our understanding of the pathways of communication among mind, body, and spirit. |
 |
Gene Regulation (BIOS Advanced Text) by David Latchman (Author) Gene regulation is an essential process in the development and maintenance of a healthy body, and as such is a central focus in both basic science and medical research. Gene Regulation, Fifth Edition, provides the student with a clear, up-to-date description of gene regulation in eukaryotes, distilling the vast and complex primary literature into a concise overview. For this fifth edition, in addition to extensive updating of existing material, sections on large-scale methodologies have been expanded, and a new section included on regulation by small interfering RNAs. More detail has been added on the role of multi-protein complexes in transcriptional activation and the discussion of the regulation of transcription factor activity by specific modifications to include acetylation... |
 |
Gene Expression by Seed Media Group A scientific blog interested in evolutionary biology, with a particular focus on evolutionary, population and quantitative genetics. Kindle blogs are fully downloaded onto your Kindle so you can read them even when you're not wirelessly connected. And unlike RSS readers which often only provide headlines, blogs on Kindle contain full text content and images, and are updated wirelessly throughout the day. |
 |
Statistical Analysis of Gene Expression Microarray Data by Terry Speed (Editor) Although less than a decade old, the field of microarray data analysis is now thriving and growing at a remarkable pace. Biologists, geneticists, and computer scientists as well as statisticians all need an accessible, systematic treatment of the techniques used for analyzing the vast amounts of data generated by large-scale gene expression studies. And there is arguably no group better qualified to do so than the authors of this book.Statistical Analysis of Gene Expression Microarray Data promises to become the definitive basic reference in the field. Under the editorship of Terry Speed, some of the world's most pre-eminent authorities have joined forces to present the tools, features, and problems associated with the analysis of genetic microarray data. These include::"Model-based... |
 |
DNA Microarrays and Gene Expression: From Experiments to Data Analysis and Modeling by Pierre Baldi (Author), G. Wesley Hatfield (Author), Wesley G. Hatfield (Author) Massive data acquisition technologies--such as genome sequencing, high-throughput drug screening, and DNA arrays--are in the process of revolutionizing biology and medicine. This concise, user-friendly and interdisciplinary guide to DNA microarray technology is an introduction and a reference for both biologists and computational scientists. The authors describe the underlying technologies and offer an awareness of the "noise" and pitfalls present in the data generated. They also provide an idea of the different data mining techniques and algorithms that are available to interpret data, and the advantages and disadvantages of each in differing situations. |
 |
Gene Wilder Autographed 8x10 Photo Beautiful photograph. Printed on photographic paper from an actual negative. Add to your collection. Will look great on a media room wall. Please check out the rest of our collection. Will be adding more. |
|
Techniques in Genetic Engineering 5: Expression of Cloned Genes [VHS] Starring: Tim Harris | |
 |
Celestial Plea by Gene Newton |
| © 2009 BrightSurf.com |