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GEN highlights increasing use of digital gene expression profiling
April 06, 2009A novel technique for carrying out gene-expression profiling is set to challenge the market dominance of the current, widely used methodology, reports Genetic Engineering & Biotechnology News (GEN). Some scientists believe that digital gene-expression profiling, a fully quantitative approach for gene-expression analysis, will eventually rival microarrays in this application area, according to the April 1 issue of GEN (http://www.genengnews.com/articles/chitem.aspx?aid=2844).
"Digital gene expression technologies are certainly catching the attention of the life science research community," says John Sterling, Editor in Chief of GEN. "The approach looks to be especially appealing to those working in the area of transcriptomics.
A group of Dutch researchers compared deep sequencing-based gene-expression analysis using the Illumina whole genome sequencer to five microarray-based platforms. They concluded that deep sequencing provides a major advance in robustness, comparability, and richness of expression profiling data. The scientists predict that with the continuously increasing number of reads at reduced costs, RNASeq, a.k.a. whole transcriptome shotgun sequencing, will become affordable for standard differential gene-expression analysis.
DNAStar recently introduced QSeq, the first product to use the company's disk sort alignment algorithm for quantitative RNASeq applications and digital gene-expression experiments. DNAStar officials view RNASeq as being is in the validation stage.
Mary Ann Liebert, Inc./Genetic Engineering News
DNAStar recently introduced QSeq, the first product to use the company's disk sort alignment algorithm for quantitative RNASeq applications and digital gene-expression experiments. DNAStar officials view RNASeq as being is in the validation stage.
Mary Ann Liebert, Inc./Genetic Engineering News
Gene-expression Current Events and Gene-expression News RSSWill IVF work for a particular patient? The answer may be found in her blood
For the first time, researchers have been able to identify genetic predictors of the potential success or failure of IVF treatment in blood.
U of I study: Fructose metabolism more complicated than was thought
A new University of Illinois study suggests that we may pay a price for ingesting too much fructose. According to lead author Manabu Nakamura, dietary fructose affects a wide range of genes in the liver that had not previously been identified.
Type-1 diabetes not so much bad genes as good genes behaving badly, Stanford research shows
Investigators combing the genome in the hope of finding genetic variants responsible for triggering early-onset diabetes may be looking in the wrong place, new research at the Stanford University School of Medicine suggests.
New Electrostatic-based DNA Microarray Technique Could Revolutionize Medical Diagnostics
The dream of personalized medicine - in which diagnostics, risk predictions and treatment decisions are based on a patient's genetic profile - may be on the verge of being expanded beyond the wealthiest of nations with state-of-the-art clinics.
Gene-expression profiling of the effects of liver toxins
Gene-expression data from liver tissue or whole blood can be used to classify histopathologic differences in the effects of hepatotoxins. It is hoped that these findings, published in BioMed Central's open access journal, Genome Biology, will lead to a more precise way of defining the potential hepatotoxicity of new compounds.
How advanced prostate cancer becomes resistant to androgen-deprivation therapy
For the past 70 years the treatment of choice for advanced, metastatic prostate cancer has been androgen-deprivation therapy.
Estrogen Helps Drive Distinct, Aggressive Form of Prostate Cancer
Using a breakthrough technology, researchers led by a Weill Cornell Medical College scientist have pinpointed the hormone estrogen as a key player in about half of all prostate cancers.
Molecular science could further improve leukemia survival, say St. Jude researchers
The dramatic increase that has occurred in the cure rate for children with acute lymphoblastic leukemia (ALL) will be difficult to replicate in older patients without considerable additional research.
Immune cells fighting chronic infections become progressively 'exhausted,' ineffective
A new study of immune cells battling a chronic viral infection shows that the cells, called T cells, become exhausted by the fight in specific ways, undergoing profound changes that make them progressively less effective over time.
New genetic marker characterizes aggressiveness of cancer cells
Levels of a small non-coding RNA molecule called let-7 appear to define different stages of cancer better than some of the "classical" markers for tumor progression.
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