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Enzyme therapy slows kidney function decline
April 09, 2009For men with Fabry disease, enzyme replacement therapy (ERT) with agalsidase alfa slows deterioration of kidney function, reports a study in the online edition of the Journal of the American Society of Nephrology (JASN). "The results provide further evidence that ERT with agalsidase alfa may slow the progression of kidney disease, provided that ERT is initiated early in the disease process," comments Michael L. West, MD (Dalhousie University, Canada).
The researchers pooled the results of three previous clinical trials of ERT with agalsidase alfa in 108 men with Fabry disease-a rare genetic disorder. Without treatment, Fabry disease causes progressive loss of kidney function, eventually leading to end-stage renal disease.
During treatment with an inactive placebo, kidney function declined rapidly. By comparison, during treatment with agalsidase alfa (1 to 4.5 years), the rate of decline slowed considerably. The response to treatment was not as good for patients with lower initial kidney function. "This underlines the importance of prompt diagnosis and intervention in patients with Fabry disease," adds Dr. West.
The study was one of the largest ever of men with Fabry disease and included the most accurate techniques of measuring kidney function. The study also had important limitations: it used data from different studies performed at different times; it represented a relatively narrow range of patient characteristics, specifically excluding children and women; and it lacked adequate data for full statistical analysis.
While not approved for use in the US, Agalsidase alfa is approved for use in over 40 countries including Canada, European countries, Argentina, Australia, and Japan. A related drug called agalsidase beta is approved in the US.
Dr. West has received research funding and other fees from Shire Human Genetic Therapies Inc. and other drug companies.
American Society of Nephrology
The study was one of the largest ever of men with Fabry disease and included the most accurate techniques of measuring kidney function. The study also had important limitations: it used data from different studies performed at different times; it represented a relatively narrow range of patient characteristics, specifically excluding children and women; and it lacked adequate data for full statistical analysis.
While not approved for use in the US, Agalsidase alfa is approved for use in over 40 countries including Canada, European countries, Argentina, Australia, and Japan. A related drug called agalsidase beta is approved in the US.
Dr. West has received research funding and other fees from Shire Human Genetic Therapies Inc. and other drug companies.
American Society of Nephrology
Kidney Function Current Events and Kidney Function News RSSHelp your kidneys: Pass on salt and diet soda
Individuals who consume a diet high in sodium or artificially sweetened drinks are more likely to experience a decline in kidney function, according to two papers being presented at the American Society of Nephrology's annual meeting in San Diego, California.
The cost of improving dialysis care
Improving survival among dialysis patients may increase treatment costs significantly, according to a paper being presented at the American Society of Nephrology's 42nd Annual Meeting and Scientific Exposition in San Diego, CA.
Can charcoal fight heart disease in kidney patients?
Charcoal may provide a new approach to managing the high rate of heart disease in patients with advanced kidney disease, according to preliminary research being presented at the American Society of Nephrology's 42nd Annual Meeting and Scientific Exposition in San Diego, CA.
Women with chronic kidney disease more likely than men to go undiagnosed
Woman are at particular risk of their primary care physicians delaying diagnosis of chronic kidney disease (CKD), according to a paper being presented at the American Society of Nephrology's 42nd Annual Meeting and Scientific Exposition in San Diego, California.
Calculate benefit before dialysis for frail elders
Kidney specialists should weigh the potential quality of life for frail elders with end-stage renal disease (ESRD) in opting for dialysis over more conservative therapies, a nephrologist and a palliative care specialist suggest in an editorial in the New England Journal of Medicine.
Study questions need for routine intervention in patients with renovascular disease
Some invasive procedures that are becoming increasingly common as a first line of treatment for patients diagnosed with narrowed arteries in and around the kidneys may not be necessary.
Kidneys from deceased donors with acute renal failure expand donor pool
Kidneys recovered from deceased donors with acute renal failure (ARF) - once deemed unusable for transplant - appear to work just as well as kidneys transplanted from deceased donors who do not develop kidney problems prior to organ donation.
Impaired kidney function linked to cognitive decline in elderly
A new study published in the medical journal Neurology suggests that impaired kidney function is a risk factor for cognitive decline in old age.
U finds treatment that significantly slows progression of eye damage in persons with type 1 diabetes
University of Minnesota Medical School researcher Michael Mauer, M.D., has found a treatment that significantly slows the progression of eye injury in people with type 1 diabetes, a common complication caused by this disease.
Mayo Genomic Discovery: Protecting Kidney Function During Heart Failure
Mayo Clinic cardiology researchers have found a peptide that helps preserve and improve kidney function during heart failure, without affecting blood pressure.
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The Vegetarian Diet For Kidney Disease Treatment: Preserving Kidney Function With Plant Based Eating by Joan Brookhyser CSR (Author) Whether you are currently a vegetarian or just searching for a safe diet to follow with kidney disease, this book is for you. Based on the author's 20 years of experience in nutrition counseling for chronic kidney disease, this book provides easy to follow guidelines for plant based eating, to help slow down kidney function decline while keeping you healthy. Nutrition guidelines for different levels of kidney function are outlined. In addition many other nutritional tips are provided for your disease management. Several recipes are included to add variety to your eating. |
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Punarnavadi Guggulu - For healthy kidney, heart and joint function. Reduces Kapha, helps with joint pain and swelling.* - 80 Tablets by TriDosha Wellness Products Ayurveda uses Punarnavadi Guggulu to reduce excess Kapha. Traditionally used for kidney, heart and joint health. Supports healthy elimination of fluid from the body, promotes healthy circulation and proper joint movement.* |
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SciEd Modeling Kidney Function; 40 Student by Neo/Sci Corporation Anatomy, Kidney Function; Students construct model of kidney using semipermeable membrane to filter completely safe solution simulates blood; Filtrate resembles urine, which students test for salt and other waste products |
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Canine Kidney Solution Booster by Healthy Pet Solutions Kidney Solution Booster for Dogs is recommended to be taken in conjuntion with Kidney Solution II. It provides necessary support for dogs suffering with severe kidney dysfunction or renal failure issues. Kidney Solution Booster is natural diuretic which helps purge the body of built up toxins like Creatinine and Urea. Over time and when combined with Kidney Solution II, Kidney Solution Booster helps lower toxins. Measurable results are typically seen in about three months. An improvement in physical symptoms can often be seen in the first month to two months. |
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Renal Pet Formula - Promote Healthy Kidney Function in Your Pet - 30g by WLI Promote healthy kidney function for your pets with this special formula of elk velvet antler and traditional Chinese herbs. This products is premium from beginning to end. Only the best genetics are carefully selected for the bulls and cows to breed the healthiest, most promising stock. The elk are raised in a completely natural environment. To reduce stress, grazing land does not exceed two animals per acre. Routine health checks and inventory programs keep the animals in optimal health. Antlers are removed once a year from healthy bulls in a low stress and drug-free process. An advanced extraction process is used to keep the nutrients in their most potent state. In addition, all supplements can be traced back to the herd and bull origin. The production process of the velvet antler... |
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Botanic Choice Blueberry Tablets (Pack of 6) by Botanic Choice Do you know how important your pancreas is? It is responsible for producing enzymes needed to digest carbohydrates, fats, and proteins. It also produces insulin to maintain proper balance of blood-sugar levels. Blueberry Leaf provides a simple, effective way to help maintain natural sugar levels already within the normal range while working safely to promote pancreatic health. Not only does Blueberry Leaf support the pancreas, it can also help your urinary tract. This gentle herb nourishes and detoxifies the kidneys. Feel the positive effects that Blueberry Leaf Tablets will have on your health by trying them today. . |
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The Vegetarian Diet for Kidney Disease: Preserving Kidney Function with Plant-Based Eating by Joan B. Hogan (Author) | |
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Kidney Well 11 (200 Tablets) by Get Well Naturals Nutritional support for the following conditions: Chronic Glomerulonephritis Nephrotic Syndrome Proteinuria IgA This specific formulation has been developed, tested, and implemented by our own Medical Doctors through their extensive research and personal practices. Kidney-Well II is manufactured utilizing pharmaceutical standards and offers the highest concentrations in the industry (30-1 instead of 5-1). Higher concentrations equate to superior results. Kidney-Well II is natural herbal supplements with anti-oxidants, cellular cleansing and cellular energy enhancing activities. It supports healthy kidney function which is important for proper kidney filtration and protection from toxic damage. The herbs contained in Kidney-Well II have shown very positive effects for people with... |
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Renal Pet Formula - Promote Healthy Kidney Function in Your Pet - 15g by WLI Promote healthy kidney function for your pets with this special formula of elk velvet antler and traditional Chinese herbs. This product is premium from beginning to end. Only the best genetics are carefully selected for the bulls and cows to breed the healthiest, most promising stock. The elk are raised in a completely natural environment. To reduce stress, grazing land does not exceed two animals per acre. Routine health checks and inventory programs keep the animals in optimal health. Antlers are removed once a year from healthy bulls in a low stress and drug-free process. An advanced extraction process is used to keep the nutrients in their most potent state. In addition, all supplements can be traced back to the herd and bull origin. The production process of the velvet antler is... |
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