 |
|
Biological FM signal maintains inflammation in cancer, asthma and other diseases
April 10, 2009A study published tomorrow (10 April) in Science examines a key player in conditions such as cancer, inflammatory bowel disease, rheumatoid arthritis and asthma and has shown that cells use a sophisticated communication system to coordinate responses to infection and maintain inflammation in the body. This system is now a target for designing drugs to treat these conditions.
Scientists funded by the Biotechnology and Biological Sciences Research Council (BBSRC), the Medical Research Council (MRC) and the Engineering and Physical Sciences Research Council (EPSRC) have combined biological experiments and mathematics to discover the secrets of NF-kappaB - a biological machine that coordinates the setting up and maintenance of inflammation in the body by broadcasting a signal to surrounding cells.
The team from the Universities of Liverpool, Manchester and Warwick, along with scientists from pharmaceutical company AstraZeneca (AstraZeneca R & D, Charnwood) have used Systems biology - a multidisciplinary approach that uses a combination of experimental and theoretical techniques to tackle biological problems - to investigate the role of NF-kappaB.
Professor Michael White of the University of Liverpool, who led the research said: "We know that successive peaks and troughs in the amount of NF-kappaB - forming a wave-like pattern over time - can exert exquisite control over many biological processes that underlie the symptoms of inflammation. Furthermore, what we now see is that different cell processes are determined once they pick up the frequency of peaks and troughs in the NF-kappaB signal, just like tuning in to an FM radio signal."
Professor Douglas Kell, BBSRC Chief Executive and co-author of the paper in his previous role added: "This research is an example that shows truly integrated systems biology allowing us to get right to the bottom of a complex and important biological question i.e. can we better understand the fundamental biology of inflammation in order to treat disease?
"The results of our work simultaneously aid and challenge drug designers; it will not simply be a matter of using a drug to knock down one key biological player in an inflammatory disease. This research tells us that cells in inflammatory tissues may use very precise timing to communicate between each other in order to determine the overall response to infection and the extent to which inflammation is maintained. Systems biology is enabling us to get a complete picture of the biology underpinning inflammation and thus pinpoint the potential axes of control that might be targeted with drugs."
Biotechnology and Biological Sciences Research Council
Professor Michael White of the University of Liverpool, who led the research said: "We know that successive peaks and troughs in the amount of NF-kappaB - forming a wave-like pattern over time - can exert exquisite control over many biological processes that underlie the symptoms of inflammation. Furthermore, what we now see is that different cell processes are determined once they pick up the frequency of peaks and troughs in the NF-kappaB signal, just like tuning in to an FM radio signal."
Professor Douglas Kell, BBSRC Chief Executive and co-author of the paper in his previous role added: "This research is an example that shows truly integrated systems biology allowing us to get right to the bottom of a complex and important biological question i.e. can we better understand the fundamental biology of inflammation in order to treat disease?
"The results of our work simultaneously aid and challenge drug designers; it will not simply be a matter of using a drug to knock down one key biological player in an inflammatory disease. This research tells us that cells in inflammatory tissues may use very precise timing to communicate between each other in order to determine the overall response to infection and the extent to which inflammation is maintained. Systems biology is enabling us to get a complete picture of the biology underpinning inflammation and thus pinpoint the potential axes of control that might be targeted with drugs."
Biotechnology and Biological Sciences Research Council
Inflammation Current Events and Inflammation News RSSToward explaining why hepatitis B hits men harder than women
Scientists in China are reporting discovery of unusual liver proteins, found only in males, that may help explain the long-standing mystery of why the hepatitis B virus (HBV) sexually discriminates -- hitting men harder than women.
Women at risk from vitamin A deficiency
Almost half of UK women could be suffering from a lack of vitamin A due to a previously undiscovered genetic variation, scientists at Newcastle University have found.
Can EP4 agonist alleviate gastric lesions?
Over 300 million patients use non-steroidal anti-inflammatory drugs (NSAIDs) in the world to treat pain, arthritis, fever and other diseases. Nearly 30% of the users suffer from gastric lesions and bleeding.
Immune system activated in schizophrenia
Researchers at the Swedish medical university Karolinska Institutet have discovered that patients with recent-onset schizophrenia have higher levels of inflammatory substances in their brains. Their findings offer hope of being able to treat schizophrenia with drugs that affect the immune system.
Largest gene study of childhood IBD identifies 5 new genes
In the largest, most comprehensive genetic analysis of childhood-onset inflammatory bowel disease (IBD), an international research team has identified five new gene regions, including one involved in a biological pathway that helps drive the painful inflammation of the digestive tract that characterizes the disease.
Tiny particles can deliver antioxidant enzyme to injured heart cells
Researchers at Emory University and the Georgia Institute of Technology have developed microscopic polymer beads that can deliver an antioxidant enzyme made naturally by the body into the heart.
New study links vitamin D deficiency to cardiovascular disease and death
While mothers have known that feeding their kids milk builds strong bones, a new study by researchers at the Heart Institute at Intermountain Medical Center in Salt Lake City suggests that Vitamin D contributes to a strong and healthy heart as well - and that inadequate levels of the vitamin may significantly increase a person's risk of stroke, heart disease, and death, even among people who've never had heart disease.
Aileron collaborates study in Nature: Stapled peptides inhibit Notch1 transcription factor
This research validates the potential for Stapled Peptides to modulate key intracellular biological targets, such as transcription factors, that have not been addressable with current small molecule or biologic drug modalities.
Exposure to several common infections over time may be associated with risk of stroke
Cumulative exposure to five common infection-causing pathogens may be associated with an increased risk of stroke, according to a report posted online today that will appear in the January 2010 print issue of Archives of Neurology, one of the JAMA/Archives journals.
Ice cream researchers making sweet strides with 'functional foods'
A comfort food, a tasty treat, an indulgence - ice cream conjures feelings of happiness and satisfaction for millions. Ice cream researchers at the University of Missouri have discovered ways to make ice cream tastier and healthier and have contributed to ice cream development and manufacturing for more than a century.
More Inflammation Current Events and Inflammation News Articles
 |
The Inflammation Syndrome: The Complete Nutritional Program to Prevent and Reverse Heart Disease, Arthritis, Diabetes, Allergies, and Asthma by Jack Challem (Author) "Challem’s new book hits a home run — with the latest research on what to eat and take to defeat our real number-one cause of health problems — inflammation. It’s a message of the utmost importance." –Jean Carper New York Times bestselling author of Stop Aging Now! and Your Miracle Brain, columnist for USA Weekend magazine What is the Inflammation Syndrome? It’s the cumulative effect of low-grade inflammation–including the aches and pains we all experience–that grows into chronic debilitating disease. This book, the first major book on the syndrome, reveals the powerful role that inflammation plays in a wide variety of common health conditions–from simple aches and pains to heart disease, obesity, diabetes, Syndrome X, arthritis, asthma, and... |
 |
The Anti-Inflammation Diet and Recipe Book: Protect Yourself and Your Family from Heart Disease, Arthritis, Diabetes, Allergies ? and More by N.D. Jessica K. Black (Author) The connection between inflammation and heart disease, arthritis, and other chronic ailments has become increasingly clear. Many food allergies and poor dietary choices overstimulate the immune system and cause inflammatory responses that erode the body’s wellness and pave the path for ill health. Based on her naturopathic practice, Jessica Black has devised a complete program for how to eat and cook to minimize and even prevent inflammation and its consequences. The first part of the book explains the benefits of the anti-inflammatory diet with an accessible discussion of the science behind it. The second half contains 108 recipes. The author offers many substitution suggestions and includes a healthy ingredient tip with each recipe. Most of the dishes can be prepared quickly and... |
 |
The Optimal Health Revolution: How Inflammation Is the Root Cause of the Biggest Killers and How the Cutting-edge Sceince of Nutrigenomics Can Transform Your Long-term Health by Duke Johnson (Author) Science is coming to a startling realization. The bulk of our most lethal diseases have a common underlying cause: persistent inflammation. Inflammation is an overactive reaction of our natural immune system function that results in cell and tissue destruction. This persistent inflammation is triggered by our industrial lifestyles, including exposure to chemicals, synthetic food ingredients, pollution and processed foods. "Researchers are linking inflammation to an ever-wider array of chronic illnesses," reports Newsweek's Anne Underwood. "Suddenly medical puzzles seem to be fitting together, such as why hypertension puts patients at increased risk of Alzheimer's, or why rheumatoid-arthritis sufferers have higher rates of sudden cardiac death. They're all connected on some fundamental... |
 |
Stopping Inflammation: Relieving the Cause of Degenerative Diseases by Nancy, Ph.D. Appleton (Author), G. N. Jacobs (Author) |
 |
The Complete Idiot's Guide to the Anti-Inflammation Diet by M.D., Christopher P. Cannon (Author), Elizabeth Vierck (Author) Extinguish inflammation now. New research shows that abnormal inflammation may be linked to a variety of diseases and conditions. In this book, you will find what diseases and conditions are caused by inflammation, which foods reduce inflammation and which foods contribute to inflammation, and how to tweak today’s diets to make them anti-inflammatory. |
 |
Win the War Within: The Eating Plan That's Clinically Proven to Fight Inflammation - The Hidden Cause of Weight Gain and Chronic Disease by Floyd H. Chilton (Author) Win the War Within gives you one rapid, yet powerful solution for virtually every health problem and major disease that you may face in your lifetime. And it doesn?t just mask the symptoms, it helps eliminate the root cause for over 30 chronic and even deadly ailments-naturally. |
 |
Stop Inflammation Now! by Richard Fleming (Author) An innovative cardiologist reveals the twelve main causes of heart attack and stroke, and presents his breakthrough plan to restore heart health. In this groundbreaking book, nuclear cardiologist and research scientist Dr. Richard M. Fleming exposes the devastating impact of arterial inflammation on the heart and what can be done to douse the fire within. Arterial inflammation triggers a dangerous chain reaction, wreaking havoc throughout the body. Dr. Fleming's action plan explains which tests your doctor should be performing to assess heart disease risk and tells why an angiogram is not always an accurate indicator of heart health. He also reveals a complete picture of the twelve causes of inflammation and how to defeat them. Dr. Fleming's unique two-step program... |
 |
The Inflammation Cure: Simple Steps for Reversing heart disease, arthritis, asthma, diabetes, Alzheimer's disease, osteopor by William Meggs (Author), Carol Svec (Author) "In addition to explaining inflammation's causes and its role in various diseases, the author offers advice--'an antiinflammation game plan'--on how to maintain 'inflammation balance' and feel better."--The New York Times In clear, everyday language, William Meggs, M.D., explains what causes inflammation, its relationship to disease in the body, and what steps readers can take to minimize their risk. |
 |
The Inflammation-Free Diet Plan by Monica Reinagel (Author) A revolutionary diet to help you lose weight and control disease-causing inflammation The Inflammation-Free Diet Plan will help you achieve your ideal weight--without fad dieting--while also reducing pain and allergies, slowing the aging process, and dramatically reducing your risk for dozens of medical problems. This flexible, easy-to-follow program is the ideal nutritional solution for every member of the family. At the heart of the program is the revolutionary IF Rating system that, for the first time, tells you the inflammatory or anti-inflammatory effects of all of the foods you eat. The IF Rating integrates more than twenty different nutritional factors, including essential fatty acids, glycemic index, vitamins, minerals, antioxidants, and... |
 |
The Anti-Inflammation Zone: Reversing the Silent Epidemic That's Destroying Our Health (Zone (Regan)) by Barry Sears (Author) Combat silent inflammation -- the most serious health threat you never heard of Heart disease is the #1 killer of Americans.Cancer is the #1 fear of Americans. Dementia is the #1 concern of Americans. What do these devastating illnesses have in common? All three have been linked to silent inflammation, a condition that occurs when the body's natural immune response goes awry. Silent inflammation attacks the heart, arteries, and even the brain -- and you will not even know it. Obesity is the primary cause of silent inflammation and excess body fat is causing today's epidemic rise in countless health threats. Now Dr. Barry Sears shows you how to combat silent inflammation in this comprehensive guide. His research shows that following the Zone dietary plan,... |
| © 2009 BrightSurf.com |