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Tracing resistance to the antimalarial drug sulfadoxine across Africa
April 14, 2009In research published in PLoS Medicine, Cally Roper of the London School of Hygiene & Tropical Medicine and colleagues use genetic analyses to trace the emergence and dispersal of drug-resistant Plasmodium falciparum malaria in Africa.
They find that resistance to the antimalarial drug sulfadoxine has emerged independently in multiple sites in Africa during the past 10-20 years, and that the molecular basis of resistance differs between east and west Africa. Given the potential for different levels of drug resistance associated with these different parasite strains, the results suggest that coordinated malaria control campaigns across socioeconomically linked areas in Africa may reduce the African malaria burden more effectively than campaigns that are confined to national territories.
In a related expert commentary on the new study, Tim Anderson of the Southwest Foundation for Biomedical Research, who was not involved in the study, notes: "this unusually large data set provides an extraordinarily fine-grained view of the spread of resistance alleles across Africa."
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Citation: Pearce RJ, Pota H, Evehe M-SB, Baˆ E-H, Mombo-Ngoma G, et al. (2009) Multiple Origins and Regional Dispersal of Resistant dhps in African Plasmodium falciparum Malaria. PLoS Med 6(4): e1000055. doi:10.1371/journal.pmed.1000055
http://medicine.plosjournals.org/perlserv/?request=get-document&doi=10.1371/journal.pmed.1000055
Public Library of Science
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Citation: Pearce RJ, Pota H, Evehe M-SB, Baˆ E-H, Mombo-Ngoma G, et al. (2009) Multiple Origins and Regional Dispersal of Resistant dhps in African Plasmodium falciparum Malaria. PLoS Med 6(4): e1000055. doi:10.1371/journal.pmed.1000055
http://medicine.plosjournals.org/perlserv/?request=get-document&doi=10.1371/journal.pmed.1000055
Public Library of Science
Antimalarial Drug Current Events and Antimalarial Drug News RSSResearchers describe 'implausible' chemistry that produces herbicidal compound
A soil microbe that uses chemical warfare to fight off competitors employs an unusual chemical pathway in the manufacture of its arsenal, researchers report, making use of an enzyme that can do what no other enzyme is known to do: break a non-activated carbon-carbon bond in a single step.
Best way to treat malaria: Avoid using same drug for everyone, scientists say
A team of scientists employing a sophisticated computer model pioneered at Princeton University and Resources for the Future has found that many governments worldwide are recommending the wrong kind of malaria treatment.
International health experts to enlist the public in war on African malaria
Philanthropy just got easier and a lot more accessible to the public thanks to the social networking power of the Internet and a ground-breaking partnership between a young British entrepreneur, a global health think tank and an African medical research institute.
Studies identify more effective treatment for malaria control during pregnancy in Africa
A review of previous studies indicates that two doses of a malaria preventive therapy during pregnancy provides substantial benefit to HIV-negative women in Africa, with more frequent dosing apparently necessary for HIV-positive women.
NT researchers discover breakthrough in malaria treatment
An article published in the prestigious international journal 'The Lancet' by researchers from the Menzies School of Health Research (MSHR) in Darwin has revealed a breakthrough in the battle to treat Malaria - a disease which effects 40 per cent of the worlds population.
Safer Method for Large-Scale Malaria Screening Developed
Researchers at the Johns Hopkins Bloomberg School of Public Health's Malaria Research Institute have developed a new test for detecting the malaria parasite in human urine and saliva.
Malaria treatment efficacy compromised in certain HIV-positive patients
A weakened immune response resulting from HIV infection can lead to trouble when it comes to treating malaria.
Research milestone brings goal closer of cheap antimalarial drug for developing world
Researchers striving to create a less expensive version of a life-saving antimalarial drug, artemisinin, have cleared a major hurdle, according to a new report in the journal Nature.
Older drugs may be good stopgap treatment for malaria in Africa
A combination of older malaria drugs could treat malaria efficiently in some parts of Africa until a newer antimalarial drug called is widely available in those areas, a new review of recent studies suggests.
Malaria mechanism revealed
By determining the molecular structure of a protein that enables malaria parasites to invade red blood cells, researchers have uncovered valuable clues for rational antimalarial drug design and vaccine development.
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